• 1. Precisely synthesized LiF-tipped CoF2-nanorod heterostructures improve energy storage capacities
  Siyuan Wang,Hao Fu,Jiamin Ma,Xiaomeng Shi,Huimin Wang,Zongyou Yin,Shuai Zhang,Mengdie Jin,Ziyun Zhong,Xinyun Zhai,Yaping Du Chem. Sci. 2022 13 12367
• 2. Anion effects on Li ion transference number and dynamic ion correlations in glyme–Li salt equimolar mixtures
  Keisuke Shigenobu,Masayuki Shibata,Kaoru Dokko,Masayoshi Watanabe,Kenta Fujii,Kazuhide Ueno Phys. Chem. Chem. Phys. 2021 23 2622
• 3. Li+ solvation in glyme–Li salt solvate ionic liquids
  Kazuhide Ueno,Ryoichi Tatara,Seiji Tsuzuki,Soshi Saito,Hiroyuki Doi,Kazuki Yoshida,Toshihiko Mandai,Masaru Matsugami,Yasuhiro Umebayashi,Kaoru Dokko,Masayoshi Watanabe Phys. Chem. Chem. Phys. 2015 17 8248
• 4. Li+ solvation in glyme–Li salt solvate ionic liquids
  Kazuhide Ueno,Ryoichi Tatara,Seiji Tsuzuki,Soshi Saito,Hiroyuki Doi,Kazuki Yoshida,Toshihiko Mandai,Masaru Matsugami,Yasuhiro Umebayashi,Kaoru Dokko,Masayoshi Watanabe Phys. Chem. Chem. Phys. 2015 17 8248
• 5. Oxidation of some aromatic hydrocarbons by cerium(IV) trifluoroacetate
  Richard O. C. Norman,C. Barry Thomas,Philip J. Ward J. Chem. Soc. Perkin Trans. 1 1973 2914

• Other Chemical Reagents Organic Metal Reagents

Lithium Trifluoroacetate (CAS No. 2923-17-3): A Comprehensive Overview

Lithium trifluoroacetate (CAS No. 2923-17-3) is a versatile compound with significant applications in various fields, including organic synthesis, pharmaceuticals, and materials science. This compound is characterized by its unique chemical structure, which consists of a lithium cation and a trifluoroacetate anion. The trifluoroacetate anion, in particular, imparts distinctive properties that make Lithium trifluoroacetate a valuable reagent in numerous chemical processes.

The chemical formula of Lithium trifluoroacetate is LiCF₃CO₂. It is a white crystalline solid at room temperature and is highly soluble in water and many organic solvents. This solubility profile makes it an excellent choice for reactions that require a homogeneous solution. Additionally, its low melting point (approximately 150°C) and high thermal stability contribute to its utility in a wide range of synthetic transformations.

In the realm of organic synthesis, Lithium trifluoroacetate serves as a powerful nucleophile and base. It is often used in the preparation of organometallic compounds, particularly in the formation of lithium enolates from ketones and aldehydes. These enolates are crucial intermediates in the synthesis of complex organic molecules, such as natural products and pharmaceuticals. The trifluoroacetyl group can also be used to protect carboxylic acids during multistep syntheses, providing a convenient handle for subsequent deprotection steps.

Recent research has highlighted the role of Lithium trifluoroacetate in the development of novel catalysts and catalytic systems. For instance, studies have shown that Lithium trifluoroacetate can enhance the activity and selectivity of transition metal catalysts in cross-coupling reactions. This has led to the discovery of more efficient and environmentally friendly methods for synthesizing complex molecules. One notable example is the use of Lithium trifluoroacetate-mediated palladium-catalyzed coupling reactions, which have been successfully applied in the synthesis of bioactive compounds and drug candidates.

In the pharmaceutical industry, Lithium trifluoroacetate plays a crucial role in the development of new drugs. Its ability to modulate the reactivity of functional groups makes it an essential tool in medicinal chemistry. For example, it can be used to introduce fluorine atoms into drug molecules, which can improve their pharmacokinetic properties and biological activity. Fluorinated drugs are known for their enhanced metabolic stability and improved binding affinity to target proteins, making them attractive candidates for therapeutic applications.

Beyond its applications in organic synthesis and pharmaceuticals, Lithium trifluoroacetate has also found use in materials science. It is employed as an electrolyte additive in lithium-ion batteries, where it improves the electrochemical performance by stabilizing the electrolyte solution and enhancing the rate capability of the battery. Additionally, it has been investigated for its potential use in polymer synthesis, where it can act as a chain transfer agent or initiator to control polymer molecular weight and architecture.

The environmental impact of Lithium trifluoroacetate is another important consideration. While it is generally considered safe for use in laboratory settings, proper handling and disposal practices are essential to minimize any potential environmental risks. Recent studies have focused on developing more sustainable synthetic methods that reduce waste generation and energy consumption during the production of Lithium trifluoroacetate. These efforts align with the growing emphasis on green chemistry principles in both academic and industrial research.

In conclusion, Lithium trifluoroacetate (CAS No. 2923-17-3) is a multifaceted compound with a wide range of applications across various scientific disciplines. Its unique chemical properties make it an indispensable reagent in organic synthesis, pharmaceutical development, materials science, and beyond. Ongoing research continues to uncover new uses for this versatile compound, further solidifying its importance in modern chemistry.

• 2923-16-2(Potassium trifluoroacetate)
• 3336-58-1(ammonium trifluoroacetate)
• 599-00-8(Trifluoroacetic Acid-d)
• 37737-28-3(YttriumTrifluoroacetate (~90%))
• 304851-95-4(yttrium trifluoroacetate hydrate)
• 435345-45-2(1-(4-Fluoro-benzyl)-piperazinetrifluoroacetate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)