• 1. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 2. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 5. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Styrenes

Introduction to 6-phenylhexa-3,5-dien-2-one (CAS No. 29179-13-3)

6-phenylhexa-3,5-dien-2-one, identified by the Chemical Abstracts Service registry number CAS No. 29179-13-3, is a significant organic compound that has garnered attention in the field of synthetic chemistry and pharmaceutical research. This molecule, featuring a conjugated system with a phenyl group and a diene backbone, exhibits unique structural and electronic properties that make it a valuable scaffold for developing novel bioactive molecules.

The compound’s structure consists of a hexadienone core substituted with a phenyl ring at the sixth carbon position. This arrangement confers distinct reactivity patterns, making it a versatile intermediate in organic synthesis. The presence of the carbonyl group at the second carbon and the conjugated double bonds at positions 3 and 5 contribute to its ability to participate in various chemical reactions, including Diels-Alder cycloadditions, Michael additions, and oxidation processes.

In recent years, 6-phenylhexa-3,5-dien-2-one has been explored as a building block in medicinal chemistry due to its potential to serve as a precursor for more complex pharmacophores. The phenyl ring introduces hydrophobicity and electronic modulation, while the diene system allows for further functionalization. Such features are particularly attractive for designing molecules with targeted biological activity.

One of the most compelling aspects of 6-phenylhexa-3,5-dien-2-one is its utility in generating derivatives with enhanced biological properties. Researchers have leveraged its scaffold to develop compounds with antimicrobial, anti-inflammatory, and even anticancer potential. For instance, modifications at the phenyl ring or the diene positions can alter the molecule’s interactions with biological targets, leading to improved efficacy or selectivity.

The synthesis of 6-phenylhexa-3,5-dien-2-one typically involves multi-step organic transformations starting from readily available precursors. Common synthetic routes include Friedel-Crafts alkylation followed by dehydrogenation or cross-coupling reactions to introduce the phenyl group. The precision required in these synthetic steps underscores the compound’s importance as a synthetic intermediate.

Recent advancements in computational chemistry have further highlighted the significance of 6-phenylhexa-3,5-dien-2-one. Molecular modeling studies suggest that its structure can be optimized to enhance binding affinity to specific protein targets. These insights have guided experimental efforts toward designing more potent derivatives with therapeutic applications.

The pharmacological profile of compounds derived from 6-phenylhexa-3,5-dien-2-one continues to be an area of active investigation. By systematically modifying its structure, researchers aim to uncover novel mechanisms of action and expand its therapeutic potential. This includes exploring its interactions with enzymes and receptors involved in various disease pathways.

The compound’s role in material science is also noteworthy. Its conjugated system and aromaticity make it suitable for applications in organic electronics, such as organic light-emitting diodes (OLEDs) and photovoltaic devices. The ability to fine-tune its electronic properties through structural modifications opens up possibilities for developing next-generation materials with improved performance.

In conclusion, 6-phenylhexa-3,5-dien-2-one (CAS No. 29179-13-3) is a multifaceted compound with broad applications across synthetic chemistry, pharmaceutical research, and materials science. Its unique structural features and reactivity patterns make it an invaluable tool for developing innovative solutions in these fields. As research progresses, the full potential of this molecule is expected to be realized through continued exploration and optimization.

• 1896-62-4(Benzylideneacetone)
• 307496-22-6(3-Buten-2-one-1,1,1,3,4-d5,4-(phenyl-d5)- (9CI))
• 538-58-9(1,5-Diphenylpenta-1,4-dien-3-one)
• 122-57-6(Benzylideneacetone)
• 622-21-9(Dicinnamalacetone)
• 130208-38-7(3-Buten-2-one-1,1,1,3-d4,4-phenyl- (9CI))
• 35225-79-7(trans-Dibenzylideneacetone)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)