• 1. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
  Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
• 2. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
  J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 4. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 5. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471

Professional Introduction to N-(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl-2-pyrazinecarboxamide (CAS No. 289472-80-6)

N-(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl-2-pyrazinecarboxamide, identified by its CAS number 289472-80-6, is a compound of significant interest in the field of pharmaceutical chemistry and biochemistry. This molecule, featuring a pyrazine core and an amide functional group, has garnered attention due to its structural complexity and potential biological activities. The stereochemistry at the 1S position adds an additional layer of interest, as enantiomeric purity can greatly influence pharmacological outcomes.

The< strong>pyrazine scaffold is a well-documented heterocyclic system, known for its presence in numerous bioactive molecules. Pyrazines exhibit a wide range of biological properties, including antimicrobial, antiviral, and anti-inflammatory effects. The incorporation of an amide group in this structure suggests potential interactions with biological targets such as enzymes and receptors, which are often modulated by amide-based pharmacophores.

In recent years, there has been a growing interest in the development of chiral drugs due to their improved efficacy and reduced side effects compared to their racemic counterparts. The specific stereochemistry of N-(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl-2-pyrazinecarboxamide makes it a valuable candidate for studying the impact of enantiomerism on biological activity. Studies have shown that the 1S configuration can significantly alter binding affinity and metabolic stability, making its synthesis and characterization crucial for drug development.

The< strong>phenylmethyl group, also known as benzyl, is another key feature of this compound. Benzyl groups are frequently used in medicinal chemistry due to their ability to enhance solubility, improve pharmacokinetics, and contribute to the overall stability of drug molecules. The presence of this group in conjunction with the pyrazine and amide moieties creates a complex molecular architecture that may confer unique biological properties.

Recent research has highlighted the importance of N-(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl-2-pyrazinecarboxamide in the development of novel therapeutic agents. For instance, studies have demonstrated its potential as a precursor in the synthesis of more complex molecules with targeted biological activities. The compound's ability to serve as a building block for larger scaffolds makes it particularly valuable in medicinal chemistry.

The< strong>amide functionality is known for its role in modulating protein-protein interactions and enzyme activity. In particular, amides have been extensively studied for their ability to act as hinge binders in drug design. The pyrazine-carboxamide moiety in N-(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl-2-pyrazinecarboxamide could potentially interact with specific residues in target proteins, leading to the development of highly selective drugs.

The synthesis of this compound involves multiple steps, each requiring careful optimization to ensure high yield and purity. Advanced synthetic techniques such as chiral resolution and asymmetric catalysis are often employed to achieve the desired stereochemical configuration. The complexity of the synthesis underscores the compound's significance in pharmaceutical research.

In conclusion, N-(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl-2-pyrazinecarboxamide (CAS No. 289472-80-6) represents a promising candidate for further exploration in drug discovery. Its unique structural features, including the pyrazine core, amide group, and stereochemistry at the 1S position, make it a valuable asset for medicinal chemists. As research continues to uncover new biological activities and synthetic methodologies, this compound is poised to play a significant role in the development of next-generation therapeutics.

• 862894-96-0(N(1-(3-Methylbutanamido) N(1-Des(boric Acid)) Bortezomib)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)