Cas no 288251-82-1 (5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile)

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile is a heterocyclic organic compound featuring a benzonitrile core substituted with an amino group and a 4-methylpiperazine moiety. This structure imparts versatility in pharmaceutical and agrochemical applications, particularly as an intermediate in the synthesis of biologically active molecules. The presence of both electron-donating (amino) and electron-withdrawing (nitrile) groups enhances its reactivity, enabling selective functionalization. The 4-methylpiperazine substituent contributes to improved solubility and bioavailability, making it valuable in drug discovery. Its well-defined synthetic pathway and stability under standard conditions ensure consistent performance in research and industrial processes. This compound is particularly useful in the development of kinase inhibitors and other therapeutic agents.
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile structure
288251-82-1 structure
Product Name:5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
CAS No:288251-82-1
MF:C12H16N4
MW:216.282241821289
MDL:MFCD11852581
CID:1027584
PubChem ID:17609581
Update Time:2025-05-28

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile Chemical and Physical Properties

Names and Identifiers

    • 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
    • 5-amino-2-(4-methyl-piperazin-1-yl)-benzonitrile
    • 5-amino-2-(4-methylpiperazin-l-yl)benzonitrile
    • 5-AMINO-2-(4-METHYLPIPERAZINO)BENZONITRILE
    • AKOS005171436
    • A876606
    • DTXSID30589878
    • DB-332835
    • SCHEMBL5654064
    • 288251-82-1
    • Benzonitrile, 5-amino-2-(4-methyl-1-piperazinyl)-
    • STK360706
    • CS-W022285
    • DS-2226
    • LAPZOCNBYMFZKO-UHFFFAOYSA-N
    • MFCD11852581
    • ALBB-004936
    • MDL： MFCD11852581
    • Inchi： 1S/C12H16N4/c1-15-4-6-16(7-5-15)12-3-2-11(14)8-10(12)9-13/h2-3,8H,4-7,14H2,1H3
    • InChI Key： LAPZOCNBYMFZKO-UHFFFAOYSA-N
    • SMILES： N1(C2C=CC(=CC=2C#N)N)CCN(C)CC1

Computed Properties

  • Exact Mass: 216.13700
  • Monoisotopic Mass: 216.137496527g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 1
  • Complexity: 274
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.9
  • Topological Polar Surface Area: 56.3?2

Experimental Properties

  • PSA: 56.29000
  • LogP: 1.47638

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile Security Information

  • HazardClass：IRRITANT

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-GX266-1g
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
1g
 2635.0CNY 2021-08-03
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-GX266-250mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
250mg
 1312CNY 2021-05-08
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-GX266-100mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
100mg
 626CNY 2021-05-08
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
A847338-100mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
100mg
 ￥688.50 2022-09-03
Fluorochem
220477-250mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 95%
250mg
 ￡129.00 2022-02-28
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-GX266-50mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
50mg
 346.0CNY 2021-08-04
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-GX266-200mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
200mg
 869.0CNY 2021-08-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
A192544-100mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
100mg
 ￥639.90 2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
A192544-1g
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
1g
 ￥2630.90 2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
A192544-250mg
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
 288251-82-1 98%
250mg
 ￥1036.90 2023-09-04

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile Production Method

5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile Related Literature

Related Categories

288251-82-1 (5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile) Related Products

Recommended suppliers
Shanghai Bent Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Nanjing Jubai Biopharm
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Nanjing Jubai Biopharm
Wuhan Comings Biotechnology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Wuhan Comings Biotechnology Co., Ltd.
Shanghai Aoguang Biotechnology Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Shanghai Aoguang Biotechnology Co., Ltd
Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Amadis Chemical Company Limited