• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
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• 2. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
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• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

Introduction to 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid (CAS No. 287730-18-1)

5,6-dimethyl-1H-benzimidazole-2-sulfonic acid, identified by the Chemical Abstracts Service Number (CAS No.) 287730-18-1, is a heterocyclic organic compound that has garnered significant attention in the field of pharmaceutical and biochemical research. This compound belongs to the benzimidazole family, a class of molecules known for their diverse biological activities and utility in medicinal chemistry. The presence of a sulfonic acid group at the 2-position and methyl substituents at the 5- and 6-positions introduces unique chemical properties that make it a valuable scaffold for drug discovery and material science applications.

The structural framework of 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid consists of a benzene ring fused with a pyridazine ring, with sulfur atoms incorporated into the structure. This sulfonic acid derivative is characterized by its high solubility in water due to the polar nature of the -SO?H group, which facilitates its use in aqueous-based formulations and biological assays. The compound’s ability to act as a hydrogen bond acceptor and donor makes it particularly interesting for interactions with biological targets such as enzymes and receptors.

In recent years, 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid has been explored for its potential applications in medicinal chemistry. Researchers have leveraged its structural features to develop novel inhibitors targeting various therapeutic pathways. For instance, studies have demonstrated its role as a modulator of enzyme activity, particularly in the context of metabolic diseases and inflammatory conditions. The sulfonic acid moiety serves as a key pharmacophore, enabling selective binding to biological targets while minimizing off-target effects.

One of the most compelling aspects of 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid is its versatility in chemical modifications. The benzimidazole core can be further functionalized to enhance bioactivity or improve pharmacokinetic properties. For example, derivatives of this compound have been investigated for their antimicrobial and antiviral properties, highlighting its broad spectrum of potential applications. The ability to introduce additional substituents allows chemists to fine-tune the compound’s properties for specific biological functions.

Recent advancements in computational chemistry have also contributed to the understanding of 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid’s interactions with biological systems. Molecular docking studies have revealed that this compound can bind to specific pockets on enzymes and receptors, suggesting its utility as a lead compound for drug development. These computational insights have accelerated the design of novel derivatives with enhanced affinity and selectivity.

The pharmaceutical industry has shown particular interest in 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid due to its potential as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its structural features make it an attractive candidate for further development into drugs targeting neurological disorders, cancer, and autoimmune diseases. Preclinical studies have begun to explore its efficacy in animal models, providing preliminary evidence of its therapeutic potential.

Beyond pharmaceutical applications, 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid has found utility in material science. Its ability to form stable complexes with metal ions has led to investigations into its use as a ligand in catalytic systems. These complexes exhibit unique catalytic properties that could be leveraged in industrial processes or environmental remediation efforts.

The synthesis of 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid involves multi-step organic reactions that require precise control over reaction conditions. Advanced synthetic methodologies have been developed to improve yield and purity, ensuring that researchers can obtain high-quality material for their studies. Techniques such as sulfonation followed by cyclization are commonly employed to construct the benzimidazole core structure.

Quality control and analytical methods are critical for ensuring the consistency and reliability of 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid used in research and industrial applications. High-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry are routinely employed to confirm purity and identify impurities. These analytical techniques provide confidence that the compound meets stringent standards before being used in sensitive experiments.

The future prospects for 5,6-dimethyl-1H-benzimidazole-2-sulfonic acid are promising, with ongoing research aimed at expanding its applications. Collaborative efforts between academia and industry are expected to drive innovation in this field, leading to new therapeutic agents and advanced materials based on this versatile compound. As our understanding of its properties grows, so too will its significance in addressing global challenges in health and technology.

• 929960-88-3(1H-Benzimidazole-2-sulfonic acid, 6-benzoyl-)
• 1071368-98-3(4-Methyl-1H-benzimidazole-2-sulfonic acid)
• 106135-27-7(6-methyl-1H-Benzimidazole-2-sulfonic acid)
• 106135-29-9(1H-Benzimidazole-2-sulfonic acid, 5-(aminocarbonyl)-)
• 114804-41-0(1H-Benzimidazole-6-carboxylic acid, 2-sulfo-)
• 115416-21-2(1H-Benzimidazole-2-sulfonic acid, monohydrate)
• 40341-22-8(1H-Benzimidazole-2-sulfonic acid, 5-butyl-)
• 40828-54-4(1H-1,3-benzodiazole-2-sulfonic acid)
• 677355-44-1(1H-BENZIMIDAZOLE-2-SULFONIC ACID, 5-(TRIFLUOROMETHYL)-)
• 287730-16-9(5-Bromo-1H-benzoimidazole-2-sulfonic acid)