• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 5. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Comprehensive Overview of 5-(Bromomethyl)-2,3-dichloropyridine (CAS No. 287714-93-6)

5-(Bromomethyl)-2,3-dichloropyridine (CAS No. 287714-93-6) is a halogenated pyridine derivative with significant applications in pharmaceutical and agrochemical research. This compound, characterized by its bromomethyl and dichloro substituents, serves as a versatile intermediate in organic synthesis. Its molecular structure, C₆H₄BrCl₂N, enables diverse functionalization, making it valuable for constructing complex molecules. Researchers frequently explore its reactivity in cross-coupling reactions, nucleophilic substitutions, and as a precursor for bioactive compounds.

The growing interest in 5-(Bromomethyl)-2,3-dichloropyridine aligns with trends in green chemistry and sustainable synthesis. Scientists are optimizing its production to minimize waste and energy consumption, addressing environmental concerns. Recent publications highlight its role in developing crop protection agents and pharmaceutical scaffolds, particularly in kinase inhibitor design. Its CAS No. 287714-93-6 is often searched alongside terms like "pyridine derivatives in drug discovery" or "halogenated building blocks," reflecting its relevance in modern R&D.

Analytical techniques such as HPLC, NMR, and mass spectrometry are essential for characterizing 5-(Bromomethyl)-2,3-dichloropyridine. Purity thresholds (>98%) are critical for reproducibility in medicinal chemistry applications. Storage recommendations typically suggest anhydrous conditions at 2-8°C to preserve its bromomethyl reactivity. Suppliers often provide technical data sheets detailing stability, solubility (e.g., in DMSO or THF), and compatibility with common reagents.

Innovative applications of this compound include its use in metal-organic frameworks (MOFs) and catalysis. The 2,3-dichloropyridine moiety contributes to ligand design in transition metal complexes, while the bromomethyl group facilitates post-synthetic modifications. Such versatility explains its frequent appearance in patents related to electronic materials and specialty chemicals.

Safety protocols for handling CAS 287714-93-6 emphasize standard laboratory precautions, including glove use and ventilation. While not classified as high-risk, its halogenated structure warrants proper waste disposal per local regulations. Environmental fate studies indicate moderate persistence, prompting development of biodegradable analogs in some applications.

The market for 5-(Bromomethyl)-2,3-dichloropyridine reflects broader demand for fine chemicals. Pricing trends correlate with bromine availability and synthetic route efficiency. Custom synthesis services increasingly offer isotope-labeled versions (¹³C, ¹⁵N) for metabolic research, expanding its utility in isotope dilution analysis and tracer studies.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)