Cas no 28643-80-3 (Nigericin sodium salt)
Nigericin sodium salt is a polyether antibiotic and ionophore widely used in biochemical and physiological research. It selectively transports monovalent cations, particularly K? and H?, across biological membranes, facilitating ion exchange and disrupting transmembrane potential. This property makes it valuable for studying mitochondrial function, cellular ion homeostasis, and pH regulation. Nigericin sodium salt is also employed as an uncoupler in oxidative phosphorylation research, enabling precise control of ion gradients. Its high purity and stability ensure reliable experimental reproducibility. The compound is soluble in organic solvents and exhibits consistent performance in both in vitro and cell-based assays, making it a preferred tool for mechanistic studies in bioenergetics and membrane biology.
Nigericin sodium salt structure
Product Name:Nigericin sodium salt
CAS No:28643-80-3
MF:C40H67NaO11
MW:746.943165063858
MDL:MFCD30377206
CID:53354
PubChem ID:24897813
Update Time:2025-06-07
Nigericin sodium salt Chemical and Physical Properties
Names and Identifiers
-
- Nigericin sodium salt
- Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate
- Nigericin (sodium salt)
- Nigericin . sodium salt
- Nigericin sodium salt (Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A)
- nigericinsodiumsaltfromstreptomyceshygroscopicus
- Sodium Nigericin
- Sodium(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trim
- Antibiotic K178 Antibiotic X464 Azalomycin
- Antibiotic K178,Antibiotic X464,Azalomycin M,Helexin C,Polyetherin A
- nigericin.Na
- Nigericin, sodium salt (1:1)
- NSC292567
- Neuro_000147
- Nigericin, sodium salt(1:1)
- BCP13661
- 2-[6-[[2-[5-[5-[6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxol
- B7644
- sodium;(2S)-2-[(2R,3S,6R)-6-[[(2S,4S,5R,6R,7S,9R)-2-[(2R,5R)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydrox
- AKOS024418750
- CCG-208241
- NIGERICIN SODIUM SALT [MI]
- NIGERICIN, MONOSODIUM SALT
- sodium(R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate
- sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate
- MLS001336037
- 28643-80-3
- Sodium;(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
- 28380-24-7
- NSC 292567
- UNII-DGN38HI976
- SMR000875327
- Antibiotic K178
- Nigericin sodium
- D82021
- Nigericin sodium salt, >=98% (TLC)
- (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
- Q27276393
- MLS001336038
- HY-100381
- sodium;(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
- NSC-292567
- CS-5717
- CHEMBL2165715
- DGN38HI976
- MOYOTUKECQMGHE-PDEFJWSRSA-M
- DA-66092
- Nigericin sodium salt?
- GLXC-10876
-
- MDL： MFCD30377206
- Inchi： 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
- InChI Key： MOYOTUKECQMGHE-PDEFJWSRSA-M
- SMILES： [Na+].O1[C@@]2([C@H](C)[C@@H](C[C@@H](C[C@H]3CC[C@H](C)[C@H]([C@H](C(=O)[O-])C)O3)O2)OC)[C@H](C)C[C@@]1(C)[C@H]1CC[C@@](C)([C@H]2[C@@H](C)C[C@H]([C@@H]3[C@@H](C)C[C@@H](C)[C@@](CO)(O)O3)O2)O1
Computed Properties
- Exact Mass: 746.45800
- Monoisotopic Mass: 746.458
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 11
- Heavy Atom Count: 52
- Rotatable Bond Count: 9
- Complexity: 1240
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 17
- Undefined Atom Stereocenter Count : 2
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 145
Experimental Properties
- Density: 1.1900
- Melting Point: 157 - 159°C
- Boiling Point: 779.9°Cat760mmHg
- Flash Point: 226.9°C
- Solubility: Soluble in chloroform, methanol or ethanol
- PSA: 145.20000
- LogP: 4.37090
- Merck: 13,6569
Nigericin sodium salt Security Information
-
Symbol:
- Signal Word：Danger
- Hazard Statement： H301,H315,H319,H335
- Warning Statement： P261,P301+P310,P305+P351+P338
- Hazardous Material transportation number：UN 3462
- WGK Germany：3
- Hazard Category Code： R25;R36/37/38
- Safety Instruction： S26-S36/37/39-S45
- RTECS：QT6840000
-
Hazardous Material Identification：
- Packing Group：III
- Hazard Level：6.1(b)
- Safety Term： 6.1(b)
- Packing Group：III
- Risk Phrases：R25; R36/37/38
- HazardClass：6.1
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Nigericin sodium salt Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| S e l l e c k ZHONG GUO | S6653-5mg |
Nigericin sodium salt |
28643-80-3 | 100.00% | 5mg |
￥794.43 | 2023-09-15 | |
| S e l l e c k ZHONG GUO | S6653-25mg |
Nigericin sodium salt |
28643-80-3 | 100.00% | 25mg |
￥1777.23 | 2023-09-15 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R023758-25mg |
Nigericin sodium salt |
28643-80-3 | 98% | 25mg |
￥1784 | 2024-05-24 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R023758-5mg |
Nigericin sodium salt |
28643-80-3 | 98% | 5mg |
￥635 | 2024-05-24 | |
| SHANG HAI YUAN YE Biotechnology Co., Ltd. | B24364-5mg |
Nigericin sodium salt |
28643-80-3 | ,Purity≥98% | 5mg |
￥1500.00 | 2021-09-02 | |
| ChemScence | CS-5717-5mg |
Nigericin sodium salt |
28643-80-3 | ≥98.0% | 5mg |
$90.0 | 2022-04-27 | |
| ChemScence | CS-5717-10mg |
Nigericin sodium salt |
28643-80-3 | ≥98.0% | 10mg |
$150.0 | 2022-04-27 | |
| Chemenu | CM139692-100mg |
Nigericin sodium salt |
28643-80-3 | 98% | 100mg |
$327 | 2021-08-05 | |
| TRC | N598523-5mg |
Nigericin Sodium Salt |
28643-80-3 | 5mg |
$64.00 | 2023-05-17 | ||
| TRC | N598523-10mg |
Nigericin Sodium Salt |
28643-80-3 | 10mg |
$ 81.00 | 2023-09-06 |
Nigericin sodium salt Related Literature
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Xiujuan Shi,Neng Yan,Guangle Niu,Simon H. P. Sung,Zhiyang Liu,Junkai Liu,Ryan T. K. Kwok,Jacky W. Y. Lam,Wen-Xiong Wang,Herman H.-Y. Sung,Ian D. Williams,Ben Zhong Tang Chem. Sci. 2020 11 3152
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Xiaodong Wang,Li Fan,Xiaoran Zhang,Qi Zan,Wenjuan Dong,Shaomin Shuang,Chuan Dong Analyst 2020 145 7018
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Panshu Song,Xiaotong Chen,Yu Xiang,Lei Huang,Zhaojuan Zhou,Ruirui Wei,Aijun Tong J. Mater. Chem. 2011 21 13470
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Li Fan,Qiaoling Liu,Dongtao Lu,Heping Shi,Yunfeng Yang,Yingfu Li,Chuan Dong,Shaomin Shuang J. Mater. Chem. B 2013 1 4281
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Jin Zhou,Canliang Fang,Tianjun Chang,Xiangjun Liu,Dihua Shangguan J. Mater. Chem. B 2013 1 661
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- 109345-56-4(3-O-DemethylmonensinB)
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