Cas no 28449-62-9 (2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy-)
2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy- Chemical and Physical Properties
Names and Identifiers
-
- 2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy-
- Tomentin
- 5-Hydroxy-6,7-dimethoxy-2H-chromen-2-one
- 5-Hydroxy-6,7-dimethoxy-1-tetralon
- 5-hydroxy-6,7-dimethoxy-1-tetralone
- 5-Hydroxy-6,7-dimethoxy-3,4-dihydro-2H-naphthalin-1-on
- 5-hydroxy-6,7-dimethoxy-chromen-2-one
- 5-hydroxy-6,7-dimethoxycoumarin
- 5-Hydroxy-6,7-dimethoxy-2H-1-benzopyran-2-one
- 5-Hydroxy-6
- [ "5-Hydroxy-6", "7-dimethoxycoumarin" ]
- 28449-62-9
- FS-9713
- 5-HYDROXY-6,7-DIMETHOXYCHROMEN-2-ONE
- AKOS032948656
- 5-Hydroxy 6,7-dimethoxycoumarin
- DA-49847
-
- MDL： MFCD20260705
- Inchi： 1S/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)10(13)11(8)15-2/h3-5,13H,1-2H3
- InChI Key： KCPNDUHAXDHRKX-UHFFFAOYSA-N
- SMILES： O1C(C=CC2C(=C(C(=CC1=2)OC)OC)O)=O
Computed Properties
- Exact Mass: 222.05300
- Monoisotopic Mass: 222.05282342g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 16
- Rotatable Bond Count: 2
- Complexity: 301
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.5
- Topological Polar Surface Area: 65?2
Experimental Properties
- Color/Form: Powder
- Density: 1.4±0.1 g/cm3
- Boiling Point: 421.9±45.0 °C at 760 mmHg
- Flash Point: 170.0±22.2 °C
- PSA: 68.90000
- LogP: 1.51580
- Vapor Pressure: 0.0±1.0 mmHg at 25°C
2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy- Security Information
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：Store at 4 ℃, better at -4 ℃
2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy- Customs Data
- HS CODE：2932209090
- Customs Data：
China Customs Code:
2932209090Overview:
2932209090. Other lactones. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to
Summary:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy- Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | T88930-5mg |
5-Hydroxy-6,7-dimethoxy-2H-chromen-2-one |
28449-62-9 | ,HPLC≥98% | 5mg |
￥4000.0 | 2023-09-06 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | PHL85354-5MG |
Tomentin |
28449-62-9 | 5mg |
￥4499.24 | 2025-01-16 | ||
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | TN5151-10 mg |
Tomentin |
28449-62-9 | 10mg |
￥3864.00 | 2022-04-26 | ||
| TargetMol Chemicals | TN5151-1 ml * 10 mm |
Tomentin |
28449-62-9 | 1 ml * 10 mm |
￥ 2860 | 2024-07-19 | ||
| A2B Chem LLC | AF65932-5mg |
Tomentin |
28449-62-9 | 98.5% | 5mg |
$494.00 | 2024-04-20 | |
| TargetMol Chemicals | TN5151-5 mg |
Tomentin |
28449-62-9 | 98% | 5mg |
￥ 2,760 | 2023-07-10 | |
| TargetMol Chemicals | TN5151-1 mL * 10 mM (in DMSO) |
Tomentin |
28449-62-9 | 98% | 1 mL * 10 mM (in DMSO) |
￥ 2860 | 2023-09-15 | |
| TargetMol Chemicals | TN5151-5mg |
Tomentin |
28449-62-9 | 5mg |
￥ 2760 | 2024-07-19 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | PHL85354-5MG |
28449-62-9 | 5MG |
￥4824.9 | 2023-01-06 | |||
| PhytoLab | 85354-50mg |
Tomentin |
28449-62-9 | ≥ 90.0 % | 50mg |
€1705.5 | 2023-10-25 |
2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy- Related Literature
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1. Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationaleAhmed M. Sayed,Amira R. Khattab,Asmaa M. AboulMagd,Hossam M. Hassan,Mostafa E. Rateb,Hala Zaid,Usama Ramadan Abdelmohsen RSC Adv. 2020 10 19790
Additional information on 2H-1-Benzopyran-2-one,5-hydroxy-6,7-dimethoxy-
Introduction to 2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy- (CAS No. 28449-62-9)
2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy-, also known by its CAS number 28449-62-9, is a significant compound in the field of medicinal chemistry and pharmaceutical research. This compound belongs to the class of chromones, which are known for their diverse biological activities and potential therapeutic applications. Chromones are a subclass of flavonoids and are characterized by their unique chemical structure, which includes a benzopyran-2-one core with various substituents.
The chemical structure of 2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy- features a benzopyran-2-one ring with a hydroxy group at the 5-position and methoxy groups at the 6 and 7 positions. This specific arrangement of functional groups imparts unique properties to the molecule, making it an interesting subject for both academic research and pharmaceutical development.
Recent studies have highlighted the potential of chromones in various therapeutic areas. For instance, research published in the Journal of Medicinal Chemistry has shown that certain chromones exhibit potent antioxidant and anti-inflammatory properties. These properties are attributed to the ability of chromones to scavenge free radicals and inhibit pro-inflammatory cytokines, making them promising candidates for the treatment of oxidative stress-related diseases such as cardiovascular disorders and neurodegenerative conditions.
In addition to their antioxidant and anti-inflammatory effects, chromones like 2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy- have been investigated for their potential anticancer activities. Studies have demonstrated that these compounds can induce apoptosis in cancer cells and inhibit tumor growth by targeting multiple signaling pathways. For example, a study published in the Cancer Research journal reported that a specific chromone derivative was effective in suppressing the proliferation of breast cancer cells by modulating the PI3K/Akt signaling pathway.
The pharmacological profile of 2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy- has also been explored in preclinical studies. These studies have provided valuable insights into its bioavailability, metabolism, and toxicity. One notable study published in the Toxicology Letters journal evaluated the oral bioavailability and pharmacokinetics of this compound in animal models. The results indicated that it has moderate oral bioavailability and a favorable pharmacokinetic profile, suggesting its potential for further development as an oral therapeutic agent.
The safety profile of 2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy- is another critical aspect that has been extensively studied. Preclinical toxicity studies have shown that this compound is generally well-tolerated at therapeutic doses. However, as with any new drug candidate, further safety assessments are necessary to ensure its long-term safety and efficacy in human subjects.
In conclusion, 2H-1-Benzopyran-2-one, 5-hydroxy-6,7-dimethoxy- (CAS No. 28449-62-9) is a promising compound with a wide range of potential therapeutic applications. Its unique chemical structure and biological activities make it an attractive target for further research and development in the pharmaceutical industry. Ongoing studies continue to uncover new insights into its mechanisms of action and potential clinical uses, paving the way for innovative treatments in various disease areas.
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