• 1. Self-assembled systems of water soluble metal 8-hydroxyquinolates with surfactants and conjugated polyelectrolytes
  Hugh D. Burrows,Telma Costa,M. Luisa Ramos,Artur J. M. Valente,Beverly Stewart,Licinia L. G. Justino,Aline I. A. Almeida,Nathanny Lessa Catarina,Ricardo Mallavia,Matti Knaapila Phys. Chem. Chem. Phys. 2016 18 16629
• 2. NMR, DFT and luminescence studies of the complexation of Zn(ii) with 8-hydroxyquinoline-5-sulfonate
  M. Luísa Ramos,Licínia L. G. Justino,Adriana Branco,Cláudia M. G. Duarte,Paulo E. Abreu,Sofia M. Fonseca,Hugh D. Burrows Dalton Trans. 2011 40 11732
• 3. NMR, DFT and luminescence studies of the complexation of Al(iii) with 8-hydroxyquinoline-5-sulfonate
  M. Luísa Ramos,Licínia L. G. Justino,Andreia I. N. Salvador,Andreia R. E. de Sousa,Paulo E. Abreu,Sofia M. Fonseca,Hugh D. Burrows Dalton Trans. 2012 41 12478
• 4. NMR, DFT and luminescence studies of the complexation of V(v) oxoions in solution with 8-hydroxyquinoline-5-sulfonate
  M. Luísa Ramos,Licínia L. G. Justino,Sofia M. Fonseca,Hugh D. Burrows New J. Chem. 2015 39 1488
• 5. Complexes of In(iii) with 8-hydroxyquinoline-5-sulfonate in solution: structural studies and the effect of cationic surfactants on the photophysical behaviour
  M. Luísa Ramos,Licínia L. G. Justino,Rui Barata,Telma Costa,Hugh D. Burrows Dalton Trans. 2021 50 16970

Introduction to 8-Hydroxyquinoline-5-sulfonic Acid Hydrate (CAS No. 283158-18-9) and Its Applications in Modern Chemical Biology

8-Hydroxyquinoline-5-sulfonic Acid Hydrate, identified by the chemical identifier CAS No. 283158-18-9, is a compound of significant interest in the field of chemical biology and pharmaceutical research. This hydrated derivative of hydroxyquinoline exhibits unique structural and functional properties that make it a valuable tool in various scientific applications. The compound's molecular structure, characterized by a hydroxy group at the 8th position and a sulfonic acid group at the 5th position, contributes to its solubility and reactivity, making it particularly useful in biochemical assays and drug development.

The sulfonic acid moiety in 8-Hydroxyquinoline-5-sulfonic Acid Hydrate imparts strong acidic properties, enabling its use as a buffering agent in biochemical solutions. This feature is particularly advantageous in maintaining optimal pH levels during enzymatic reactions and other sensitive biological processes. Additionally, the presence of the hydroxy group enhances its ability to form coordination complexes with metal ions, which is a critical property in catalytic systems and metal chelation studies.

Recent advancements in the field of medicinal chemistry have highlighted the potential of 8-Hydroxyquinoline-5-sulfonic Acid Hydrate as a scaffold for developing novel therapeutic agents. Researchers have been exploring its derivatives as candidates for treating various diseases, including infectious disorders and metabolic syndromes. The compound's ability to interact with biological targets such as enzymes and receptors has opened new avenues for drug design. For instance, studies have demonstrated its efficacy in inhibiting certain enzymes associated with inflammation and oxidative stress, suggesting its therapeutic potential in managing chronic inflammatory conditions.

In the realm of chemical biology, 8-Hydroxyquinoline-5-sulfonic Acid Hydrate has been utilized as a fluorescent probe for imaging biological processes. Its fluorescence properties can be modulated by environmental factors such as pH and metal ion concentration, making it a versatile tool for real-time monitoring of cellular activities. This application has been particularly valuable in studying dynamic processes within living cells, providing insights into cellular signaling pathways and metabolic activities.

The synthesis of 8-Hydroxyquinoline-5-sulfonic Acid Hydrate involves multi-step organic reactions that require precise control over reaction conditions to ensure high yield and purity. Advanced synthetic methodologies, including catalytic hydrogenation and oxidation processes, have been employed to optimize the production of this compound. These synthetic strategies not only enhance the efficiency of manufacturing but also contribute to sustainable practices by minimizing waste generation and energy consumption.

Industrial applications of 8-Hydroxyquinoline-5-sulfonic Acid Hydrate extend beyond pharmaceuticals and biochemical research. The compound has found utility in environmental science as a chelating agent for heavy metal remediation. Its ability to bind with metal ions such as lead, mercury, and cadmium makes it an effective agent for cleaning contaminated water sources. This application aligns with global efforts to protect aquatic ecosystems from heavy metal pollution.

The future prospects of 8-Hydroxyquinoline-5-sulfonic Acid Hydrate are promising, with ongoing research aimed at expanding its applications in nanotechnology and materials science. Its unique chemical properties make it a candidate for developing novel materials with enhanced functionalities, such as luminescent nanoparticles and conductive polymers. These innovations could revolutionize various industries, including electronics, energy storage, and biomedical engineering.

In conclusion, 8-Hydroxyquinoline-5-sulfonic Acid Hydrate (CAS No. 283158-18-9) is a multifaceted compound with broad applications across multiple scientific disciplines. Its structural features, reactivity, and versatility make it an indispensable tool in pharmaceutical research, biochemical assays, environmental remediation, and materials science. As scientific understanding continues to evolve, the potential uses of this compound are expected to grow, driving further innovation and discovery.

• 15301-40-3(8-Ethoxyquinoline-5-sulfonic Acid)
• 207386-92-3(5-Quinolinesulfonicacid, 8-hydroxy-, hydrate (1:?))
• 80789-76-0(Actinoquinol Sodium Salt)
• 15851-62-4(5-Quinolinesulfonicacid, 7-amino-8-hydroxy-)
• 15702-65-5(Manganate(2-),bis[8-hydroxy-5-quinolinesulfonato(2-)-N1,O8]-, dihydrogen (9CI))
• 15702-62-2(Cuprate(2-),bis[8-(hydroxy-kO)-5-quinolinesulfonato(2-)-kN1]-, dihydrogen (9CI))
• 84-88-8(8-Hydroxyquinoline-5-sulfonic acid)
• 8002-90-2(Chiniofon)
• 15702-63-3(Cobalt, bis(hydrogen8-hydroxy-5-quinolinesulfonato)- (6CI,7CI,8CI))
• 14494-69-0(Zincate(2-),bis[8-(hydroxy-kO)-5-quinolinesulfonato(2-)-kN1]-, dihydrogen, (T-4)- (9CI))