• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 4. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Research Brief on 2-Chloro-4-nitrobenzonitrile (CAS: 28163-00-0): Recent Advances and Applications in Chemical Biology and Pharmaceutical Research

2-Chloro-4-nitrobenzonitrile (CAS: 28163-00-0) is a nitro-substituted benzonitrile derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a key intermediate in the synthesis of various bioactive molecules, including agrochemicals, pharmaceuticals, and materials science applications. Recent studies have explored its utility in drug discovery, particularly in the development of kinase inhibitors and antimicrobial agents. This research brief synthesizes the latest findings on this compound, highlighting its chemical properties, synthetic applications, and biological activities.

Recent literature has emphasized the role of 2-Chloro-4-nitrobenzonitrile as a building block in medicinal chemistry. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its use in the synthesis of novel tyrosine kinase inhibitors, which showed promising activity against resistant cancer cell lines. The nitro and chloro functional groups in this compound provide reactive sites for further derivatization, enabling the creation of diverse chemical libraries for high-throughput screening. Additionally, its electron-withdrawing properties make it a valuable scaffold for designing molecules with enhanced binding affinity to biological targets.

In the realm of antimicrobial research, 2-Chloro-4-nitrobenzonitrile has been investigated as a precursor for compounds with potent activity against multidrug-resistant bacterial strains. A 2024 study in Bioorganic & Medicinal Chemistry Letters reported the synthesis of a series of derivatives that exhibited significant inhibition of Staphylococcus aureus and Escherichia coli. The study highlighted the importance of the nitro group in enhancing the compounds' ability to disrupt bacterial cell membranes. These findings underscore the potential of 2-Chloro-4-nitrobenzonitrile as a starting material for developing new classes of antibiotics.

From a synthetic chemistry perspective, advancements in catalytic methods have improved the efficiency of reactions involving 2-Chloro-4-nitrobenzonitrile. A recent publication in Advanced Synthesis & Catalysis detailed a palladium-catalyzed cross-coupling reaction that enabled the selective functionalization of this compound at the chloro position, yielding high-purity products with excellent yields. Such methodologies are critical for scaling up the production of derivatives for preclinical testing. Furthermore, computational studies have provided insights into the compound's reactivity patterns, aiding in the rational design of more efficient synthetic routes.

Looking ahead, the applications of 2-Chloro-4-nitrobenzonitrile are expected to expand into emerging areas such as targeted drug delivery and photopharmacology. Preliminary studies suggest that its nitro group can be exploited for light-activated drug release systems, offering spatiotemporal control over therapeutic activity. As research continues to uncover new facets of this versatile compound, it is poised to remain a focal point in the intersection of chemical biology and pharmaceutical innovation.

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