• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 2. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 3. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

• Solvents and Organic Chemicals Organic Compounds Benzenoids Thiophenol esters

Chemical Profile of 4-(S-Acetylthio)benzaldehyde (CAS No. 28130-89-4)

4-(S-Acetylthio)benzaldehyde, identified by its Chemical Abstracts Service registry number CAS No. 28130-89-4, is a significant compound in the realm of organic synthesis and pharmaceutical chemistry. This aromatic aldehyde derivative features a unique structural motif that combines a benzaldehyde core with an S-acetylthio functional group, making it a versatile intermediate in the synthesis of various bioactive molecules. The compound’s distinct chemical properties and reactivity have positioned it as a valuable building block in the development of pharmaceuticals, agrochemicals, and specialty chemicals.

The molecular structure of 4-(S-Acetylthio)benzaldehyde consists of a benzene ring substituted with an aldehyde group at the para position relative to the S-acetylthio moiety. This configuration imparts specific electronic and steric characteristics that influence its chemical behavior. The presence of the aldehyde group allows for nucleophilic addition reactions, while the S-acetylthio group can participate in condensation and cyclization reactions, making it a versatile precursor for constructing more complex molecules.

In recent years, 4-(S-Acetylthio)benzaldehyde has garnered attention in the pharmaceutical industry due to its potential applications in drug discovery and development. Researchers have explored its utility as an intermediate in the synthesis of heterocyclic compounds, which are known for their broad spectrum of biological activities. For instance, derivatives of this compound have been investigated for their antimicrobial, anti-inflammatory, and anticancer properties. The S-acetylthio group, in particular, has been recognized for its ability to enhance the solubility and bioavailability of certain pharmacophores, thereby improving drug delivery systems.

One of the most compelling aspects of 4-(S-Acetylthio)benzaldehyde is its role in the synthesis of protease inhibitors. Proteases are enzymes that play crucial roles in various biological processes, including signal transduction, protein degradation, and viral replication. Inhibiting specific proteases has been a successful strategy in the development of drugs for conditions such as cancer, HIV/AIDS, and inflammatory diseases. The aldehyde functionality in 4-(S-Acetylthio)benzaldehyde provides a reactive site for forming covalent bonds with protease active sites, while the S-acetylthio group can be further modified to optimize binding affinity and selectivity.

Recent advancements in computational chemistry have further highlighted the potential of 4-(S-Acetylthio)benzaldehyde as a scaffold for drug design. Molecular modeling studies have demonstrated that derivatives of this compound can effectively interact with target proteins through hydrogen bonding, hydrophobic interactions, and disulfide bridges. These interactions are critical for achieving high binding affinity and specificity, which are essential for therapeutic efficacy. Additionally, computational methods have been used to predict the metabolic stability and pharmacokinetic properties of 4-(S-Acetylthio)benzaldehyde derivatives, providing valuable insights into their potential as drug candidates.

The agrochemical industry has also recognized the significance of 4-(S-Acetylthio)benzaldehyde as a precursor for developing novel pesticides and herbicides. Its structural features make it an effective intermediate in synthesizing compounds that exhibit herbicidal activity by inhibiting key enzymes involved in plant growth regulation. Furthermore, modifications to the S-acetylthio group can enhance environmental compatibility, reducing toxicity to non-target organisms while maintaining efficacy against pests and weeds.

In conclusion, 4-(S-Acetylthio)benzaldehyde (CAS No. 28130-89-4) is a multifaceted compound with broad applications in pharmaceuticals and agrochemicals. Its unique structural features enable its use as a versatile intermediate in synthetic chemistry, particularly in the development of protease inhibitors and other bioactive molecules. The growing interest in this compound underscores its importance as a building block for innovative drug discovery and sustainable agricultural solutions.

• 10436-82-5(Ethanethioic acid, S-(3-methylphenyl) ester)
• 3128-42-5(Benzenecarbothioic acid, 4-methyl-, S-phenyl ester)
• 84211-94-9(4-(Ethylthio)benzaldehyde)
• 41117-93-5(1,3-Benzenedicarbothioic acid, S,S-bis(4-methylphenyl) ester)
• 10154-60-6(Benzenecarbothioic acid, S-2-naphthalenyl ester)
• 884-09-3(S-phenyl benzenecarbothioate)
• 10436-57-4(S-(2-Methylphenyl) ethanethioate)
• 10371-42-3(Benzenecarbothioicacid, S-(4-methylphenyl) ester)
• 10436-83-6(Ethanethioic acid,S-(4-methylphenyl) ester)
• 28118-49-2(2-Naphthalenecarbothioicacid, S-phenyl ester)