Cas no 2809-21-4 (Etidronic acid)

Etidronic acid is a bisphosphonate compound known for its efficacy in inhibiting osteoclastic bone resorption, making it useful in treatment of conditions characterized by excessive bone turnover such as Paget's disease and osteoporosis. Its mechanism of action involves binding to hydroxyapatite in bone tissue, thereby reducing bone degradation.
Etidronic acid structure
Etidronic acid structure
Product Name:Etidronic acid
CAS No:2809-21-4
MF:C2H8O7P2
MW:206.02824306488
MDL:MFCD00070585
CID:43436
PubChem ID:87570971
Update Time:2025-09-04

Etidronic acid Chemical and Physical Properties

Names and Identifiers

    • (1-Hydroxyethane-1,1-diyl)diphosphonic acid
    • (1-hydroxyethylene)diphosphonicacid
    • (1-hydroxyethylidene)bis-phosphonicaci
    • (1-hydroxyethylidene)di-phosphonicaci
    • (hydroxyethylidene)diphosphonicacid
    • 1,1,1-ethanetrioldiphosphonate
    • 1000sl
    • 1-hydroxy-1,1-diphosphonoethane
    • 1-Hydroxyethanediphosphonica
    • HEDP
    • Etidronic acid monohydrate (HEDP)
    • 1-Hydroxyethylidenebis(phosphonic acid)
    • (1-hydroxy-1-phosphonoethyl)phosphonic acid
    • 1-Hydroxyethylidene-1,1-Diphosphonic Acid
    • 1-HYDROXYETHYLIDENEDIPHOSPHONIC ACID
    • Etidronate
    • 1-Hydroxyeth
    • 1-hydroxyethane 1,1-diphosphonic acid
    • 1-Hydroxyethane-1,1-diphosphonic acid
    • EHDP
    • ethane-1-hydroxy-1,1-diphosphonic acid
    • Ethyl 3-aMinobenzoate Methanesulfonate
    • Etidronic acid
    • Etidronic acid m
    • Etidronic acid Monohydrate
    • Etidronsaeure
    • HEDPA
    • Hydroxyethanediphosphonic acid
    • Oxyethylidenediphosphonic acid
    • Turpinal SL
    • Hydroxyethylidene diphosphonic acid
    • HDEPA
    • OEDFK
    • 1-Hydroxyethylidenedi(phosphonic acid)
    • Dequest 2010
    • Etidronic Acid (ca. 60% in Water, ca. 4.2mol/L)
    • HDEPA (ca. 60% in Water, ca. 4.2mol/L)
    • HEDP (ca. 60% in Water, ca. 4.2mol/L)
    • 1-Hydroxyethylidene-1,1-diphosphonic Acid (ca. 60% in Water, ca. 4.2mol/L)
    • OEDFK (ca. 60% in Water, ca. 4.2mol/L)
    • RO Scale inhibitor for reverse osmosis film
    • 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (HEDP)
    • NCGC00159352-02
    • s1857
    • DTXCID103028
    • NCGC00159352-14
    • Acide etidronique
    • DL-390
    • 1,1-Ethylidenediphosphonic acid, 1-hydroxy-
    • Acido etidronico [INN-Spanish]
    • Hydroxyethane-1,1-diphosphonic acid
    • ETIDRONIC ACID [HSDB]
    • OEDP
    • (1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid)
    • (1-hydroxy-ethylidene)diphosphonic acid
    • ETIDRONIC ACID (MART.)
    • Etidronsaure
    • Etidronate (Didronel)
    • Prestwick1_000863
    • J-504794
    • SPBio_002826
    • Tox21_200417
    • DB01077
    • Etidronicacid
    • CCG-266618
    • NCGC00159352-06
    • HSDB 5898
    • GTPL7184
    • V10BX03
    • (1-Hydroxyethylene)diphosphonic acid
    • AKOS005524039
    • (1-Hydroxyethylidene)bisphosphonic acid
    • (1-Hydroxy-1-phosphono-ethyl)-phosphonic acid
    • BRD-K37949327-304-06-1
    • C07736
    • 1-Hydroxyethane-1,1-bisphosphonic acid
    • Etidronic acid [USAN:INN:BAN]
    • BSPBio_000905
    • NCGC00159352-04
    • M05BA01
    • (1-hydroxyethan-1,1-diyl)bis(phosphonic acid)
    • BDBM50115102
    • STK721995
    • NS00006820
    • (1-hydroxy-1-phosphono-ethyl)phosphonic acid
    • Etidronic acid (USAN/INN)
    • Ferrofos 510
    • 1-Hydroxyethanediphosphonic acid
    • Prestwick0_000863
    • Diphosphonic Acid, Hydroxyethylidene
    • RP 61
    • NSC-227995
    • HY-B0302
    • EINECS 220-552-8
    • DTXSID6023028
    • Ethane-1-hydroxy-1,1-diphosphonate
    • UNII-M2F465ROXU
    • BRD-K37949327-001-06-3
    • 1-Hydroxyethane-1,1-diphosphonate
    • Z1269201561
    • (1-Hydroxyethylidene)diphoshonic acid
    • etidronic-acid
    • Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester
    • D02373
    • Phosphonic acid, (1-hydroxyethylidene)di-
    • CAS-2809-21-4
    • Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-
    • (1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
    • s12329
    • (Hydroxyethylidene)diphosphonic acid
    • Acide etidronique [INN-French]
    • Acidum etidronicum [INN-Latin]
    • ethane-1-hydroxy-1,1-bisphosphonic acid
    • ETIDRONATE [VANDF]
    • H0587
    • Acetodiphosphonic acid
    • NCGC00159352-05
    • 1-hydroxyethane-1,1-diyldiphosphonic acid
    • Q2758338
    • CHEBI:4907
    • BRN 1789291
    • Ethane-1-hydroxy-1,1-bisphosphonate
    • NCGC00257971-01
    • C2H8O7P2
    • 2809-21-4
    • 2809-21-4 (freeacid)
    • ETIDRONIC ACID [INN]
    • MLS002695948
    • Acidum etidronicum
    • 0-02-00-00171 (Beilstein Handbook Reference)
    • SMR000038750
    • NSC 227995
    • Dequest 2015
    • Acido etidronico
    • Prestwick3_000863
    • Diphosphonate (base)
    • (1-Hydroxyethylidene)diphosphonic acid
    • HMS3604E03
    • Etidronic Acid-d3
    • 1-HydroxyEthylidene-1,1-DiphosphonicAcid
    • M2F465ROXU
    • NSC227995
    • 1-Hydroxyethylidene-1,1-biphosphonate
    • (1-Hydroxyethylidene)bis(phosphonic acid)
    • (1-Hydroxyethylidene)bisphosphonic acid 60% aqueous solution
    • ETIDRONIC ACID [MI]
    • BBL028139
    • Prestwick2_000863
    • CHEMBL871
    • ETIDRONIC ACID [USAN]
    • ETIDRONIC ACID [WHO-DD]
    • hydroxyethylidene-1,1-diphosphonic acid
    • MLS002207267
    • A23202
    • EC 220-552-8
    • 358730-93-5
    • Dequest Z 010
    • Etidronic Acid-d3 Sodium Salt
    • 1-Hydroxyethylidene-1,1-bisphosphonate
    • MFCD00070585
    • (1-Hydroxyethane-1,1-diyl)diphosphonic acid monohydrate
    • Phosphonic acid, (1-hydroxyethylidene)bis-
    • ETIDRONIC ACID [MART.]
    • SCHEMBL18607
    • BPBio1_000997
    • 1,1,1-Ethanetriol diphosphonate
    • BRD-K37949327-001-07-1
    • MDL: MFCD00070585
    • Inchi: 1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
    • InChI Key: DBVJJBKOTRCVKF-UHFFFAOYSA-N
    • SMILES: P(C(C)(O)P(=O)(O)O)(=O)(O)O
    • BRN: 1789291

Computed Properties

  • Exact Mass: 205.97500
  • Monoisotopic Mass: 205.975
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 5
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 211
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: -3.7
  • Topological Polar Surface Area: 135A^2

Experimental Properties

  • Color/Form: Colorless to yellowish mucus. The pure product is a colorless, amorphous crystal
  • Density: 1.45 (60% aq.)
  • Melting Point: 198-201°C
  • Boiling Point: 578.8°C at 760 mmHg
  • Flash Point: 303.8°C
  • Water Partition Coefficient: Soluble in water.
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents.
  • PSA: 154.91000
  • LogP: -0.99220
  • Merck: 3863
  • pka: 1.35, 2.87, 7.03, 11.3(at 25℃)
  • Solubility: Soluble in water, methanol and ethanol

Etidronic acid Security Information

Etidronic acid Customs Data

  • HS CODE:2931900090
  • Customs Data:

    China Customs Code:

    2931900090

    Overview:

    2931900090. Other organic-Inorganic compound. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods). MFN tariff:6.5%. general tariff:30.0%

    Summary:

    2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Etidronic acid Pricemore >>

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Etidronic acid Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:2809-21-4)Etidronic acid
Order Number:A1200289
Stock Status:in Stock
Quantity:500g/25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:42
Price ($):215.0/417.0
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:2809-21-4)1-Hydroxyethylidene-1,1-diphosphonic acid
Order Number:LE6695;LE2469103;LE25490776
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:49
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:2809-21-4)1-Hydroxyethylidene-1,1-diphosphonic acid
Order Number:sfd10526
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally

Etidronic acid Spectrogram

13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR
1H NMR 300 MHz DMSO
1H NMR

Etidronic acid Related Literature

Recommended suppliers
Amadis Chemical Company Limited
(CAS:2809-21-4)Etidronic acid
A1200289
Purity:99%/99%
Quantity:500g/25g
Price ($):215.0/417.0
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:2809-21-4)1-Hydroxyethylidene-1,1-diphosphonic acid
LE6695;LE2469103;LE25490776
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
Email