• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An ionic liquid-mesoporous silica blend as a novel adsorbent for the adsorption and recovery of palladium ions, and its applications in continuous flow study and as an industrial catalyst?
  Shivani Sharma,Chia-Ming Wu,Ranjit T. Koodali,N. Rajesh RSC Adv., 2016,6, 26668-26678
• 4. An anti-leakage liquid metal thermal interface material
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• 5. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives N-alkylindoles

Recent Advances in the Study of 7-Bromo-1-methyl-indole (CAS: 280752-68-3) in Chemical Biology and Pharmaceutical Research

The compound 7-bromo-1-methyl-indole (CAS: 280752-68-3) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in drug discovery and development. This heterocyclic aromatic compound, characterized by a bromine substituent at the 7-position and a methyl group at the 1-position of the indole ring, serves as a crucial intermediate in the synthesis of various biologically active molecules. Recent studies have explored its potential as a building block for novel therapeutic agents, particularly in oncology and neurology.

One of the most notable applications of 7-bromo-1-methyl-indole is its role in the synthesis of kinase inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the development of selective inhibitors for Bruton's tyrosine kinase (BTK), a key target in B-cell malignancies. The researchers utilized 7-bromo-1-methyl-indole as a core scaffold, modifying its structure to enhance binding affinity and selectivity. The resulting compounds exhibited promising in vitro and in vivo efficacy against BTK-dependent cancer cell lines, with IC50 values in the nanomolar range.

In addition to its applications in oncology, 7-bromo-1-methyl-indole has shown potential in neurological drug development. A recent preprint on bioRxiv highlighted its use in the design of serotonin receptor modulators. The study found that derivatives of 7-bromo-1-methyl-indole could selectively target 5-HT2A receptors, which are implicated in various psychiatric disorders. Molecular docking simulations revealed that the bromine substituent plays a critical role in stabilizing ligand-receptor interactions, suggesting opportunities for further optimization of this scaffold.

The synthetic accessibility of 7-bromo-1-methyl-indole has also been a focus of recent research. A 2024 paper in Organic Process Research & Development described a novel, scalable synthesis route that improves yield and reduces environmental impact compared to traditional methods. The new approach employs palladium-catalyzed cross-coupling reactions, achieving a 78% yield with excellent purity (>99%). This advancement addresses previous challenges in large-scale production, making the compound more accessible for pharmaceutical applications.

Pharmacokinetic studies of 7-bromo-1-methyl-indole derivatives have provided valuable insights into their drug-like properties. Research published in Drug Metabolism and Disposition investigated the metabolic stability and bioavailability of several analogs. The findings indicated that the methyl group at the 1-position significantly enhances metabolic stability compared to unsubstituted indoles, while the bromine atom influences distribution patterns. These properties make 7-bromo-1-methyl-indole an attractive scaffold for further medicinal chemistry optimization.

Looking forward, the unique chemical properties of 7-bromo-1-methyl-indole (280752-68-3) position it as a valuable tool in chemical biology and drug discovery. Its versatility as a synthetic intermediate, combined with emerging biological activities, suggests continued research interest in this compound. Future directions may include exploration of its applications in targeted protein degradation, antibody-drug conjugates, and other cutting-edge therapeutic modalities. As synthetic methodologies advance and biological understanding deepens, 7-bromo-1-methyl-indole is likely to remain a focal point in pharmaceutical innovation.

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