Cas no 28024-60-4 (2-amino-3-(1H-pyrazol-1-yl)propanoic acid)

2-Amino-3-(1H-pyrazol-1-yl)propanoic acid is a non-proteinogenic amino acid derivative featuring a pyrazole moiety attached to the β-carbon of the alanine backbone. This structural motif imparts unique reactivity and coordination properties, making it valuable in medicinal chemistry and ligand design. The compound’s pyrazole group enhances its potential as a chelating agent or pharmacophore in metal-organic frameworks and bioactive molecules. Its bifunctional nature—combining an amino acid backbone with a heterocyclic appendage—offers versatility in synthetic applications, including peptide modification and heterocycle-functionalized building blocks. The product is typically characterized by high purity and stability, ensuring reliability in research and industrial contexts.
2-amino-3-(1H-pyrazol-1-yl)propanoic acid structure
28024-60-4 structure
Product Name:2-amino-3-(1H-pyrazol-1-yl)propanoic acid
CAS No:28024-60-4
MF:C6H9N3O2
MW:155.154560804367
MDL:MFCD09832221
CID:283567
PubChem ID:119630
Update Time:2025-08-05

2-amino-3-(1H-pyrazol-1-yl)propanoic acid Chemical and Physical Properties

Names and Identifiers

    • 2-Amino-3-(1-pyrazolyl)propanoic Acid
    • (±)-alpha-amino-1H-pyrazole-1-propionic acid
    • 1H-Pyrazole-1-propanoicacid, a-amino-
    • 2-Amino-3-pyrazol-1-yl-propionic acid
    • 3-(1H-Pyrazol-1-yl)alanine
    • 2-amino-3-phosphonopropionate
    • 2-Amino-3-phosphonopropionic acid
    • 2-amino-3-phosphopropanoic acid
    • 2-AP3
    • DL-2-Amino-4-phosphonopropionic acid
    • 2-amino-3-(1H-pyrazol-1-yl)propanoic acid
    • PIGOPELHGLPKLL-UHFFFAOYSA-N
    • A876799
    • 3-(Pyrazol-1-yl)-DL-alanine
    • 2-amino-3-pyrazol-1-ylpropanoic acid
    • (1)-alpha-Amino-1H-pyrazole-1-propionic acid
    • EINECS 248-785-0
    • SY026507
    • SB36358
    • EN300-147175
    • MFCD09832221
    • 2-amino-3-(1H-pyrazol-1-yl)propanoicacid
    • FT-0651130
    • 28024-60-4
    • 1-pyrazolylalanine
    • L-2-Amino-3-(1-pyrazolyl)propanoic acid
    • FT-0763115
    • CHEBI:165849
    • AC5797
    • AKOS009235513
    • A5318
    • Pyrazole-1-alanine
    • NS00049266
    • DTXSID60901786
    • SCHEMBL4153679
    • Z2933867195
    • alpha-Amino-beta-(pyrazolyl-N)propionic acid
    • ( inverted exclamation markA)-alpha-amino-1H-pyrazole-1-propionic acid
    • 3-(1-Pyrazolyl)-alanine
    • 2-amino-3-pyrazol-1-yl-propanoic acid
    • propanoic acid, 2-amino-3-(1-pyrazolyl)-
    • (+/-)-alpha-amino-1H-pyrazole-1-propionic acid
    • DB-067865
    • (R)-2-Amino-3-pyrazol-1-yl-propionicacid
    • MDL： MFCD09832221
    • Inchi： 1S/C6H9N3O2/c7-5(6(10)11)4-9-3-1-2-8-9/h1-3,5H,4,7H2,(H,10,11)
    • InChI Key： PIGOPELHGLPKLL-UHFFFAOYSA-N
    • SMILES： OC(C(CN1C=CC=N1)N)=O

Computed Properties

  • Exact Mass: 155.06900
  • Monoisotopic Mass: 155.069477
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 3
  • Complexity: 151
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 81.1
  • XLogP3: -3.4

Experimental Properties

  • Density: 1.44
  • Boiling Point: 342.8°C at 760 mmHg
  • Flash Point: 161.1°C
  • Refractive Index: 1.631
  • PSA: 81.14000
  • LogP: -0.00470

2-amino-3-(1H-pyrazol-1-yl)propanoic acid Customs Data

  • HS CODE：2933199090
  • Customs Data：

    China Customs Code:

    2933199090

    Overview:

    2933199090. Other structurally non fused pyrazole ring compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-amino-3-(1H-pyrazol-1-yl)propanoic acid Suppliers

Amadis Chemical Company Limited
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(CAS:28024-60-4)2-amino-3-(1H-pyrazol-1-yl)propanoic acid
Order Number:A876799
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 09:51
Price ($):368.0

2-amino-3-(1H-pyrazol-1-yl)propanoic acid Related Literature

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Additional information on 2-amino-3-(1H-pyrazol-1-yl)propanoic acid

Recent Advances in the Study of 2-amino-3-(1H-pyrazol-1-yl)propanoic acid (CAS: 28024-60-4)

The compound 2-amino-3-(1H-pyrazol-1-yl)propanoic acid (CAS: 28024-60-4) has recently garnered significant attention in the field of chemical biology and medicinal chemistry due to its unique structural properties and potential therapeutic applications. This research briefing aims to synthesize the latest findings on this compound, focusing on its synthesis, biological activity, and potential applications in drug development.

Recent studies have highlighted the versatility of 2-amino-3-(1H-pyrazol-1-yl)propanoic acid as a building block for the design of novel bioactive molecules. Its pyrazole moiety, in particular, has been shown to interact with various biological targets, including enzymes and receptors, making it a promising scaffold for drug discovery. Researchers have employed advanced synthetic techniques, such as multi-component reactions and click chemistry, to derivatize this compound and explore its pharmacological potential.

One of the most notable findings in recent literature is the compound's role as a modulator of inflammatory pathways. In vitro and in vivo studies have demonstrated that derivatives of 2-amino-3-(1H-pyrazol-1-yl)propanoic acid exhibit significant anti-inflammatory activity by inhibiting key pro-inflammatory cytokines. This has sparked interest in its potential application for treating chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.

Additionally, the compound's structural similarity to natural amino acids has led to investigations into its use as a peptide mimetic. Researchers have successfully incorporated 2-amino-3-(1H-pyrazol-1-yl)propanoic acid into peptide sequences, resulting in enhanced stability and bioactivity. This approach has shown promise in the development of peptide-based therapeutics for various conditions, including cancer and metabolic disorders.

From a mechanistic perspective, computational modeling and X-ray crystallography studies have provided valuable insights into the molecular interactions of 2-amino-3-(1H-pyrazol-1-yl)propanoic acid with its biological targets. These structural studies have revealed specific binding modes and key intermolecular interactions that contribute to its biological activity, offering opportunities for structure-based drug design.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic properties of 2-amino-3-(1H-pyrazol-1-yl)propanoic acid derivatives. Current research efforts are focused on improving solubility, metabolic stability, and bioavailability through strategic structural modifications. Recent advances in formulation technologies, such as nanoparticle-based delivery systems, may offer solutions to these challenges.

In conclusion, 2-amino-3-(1H-pyrazol-1-yl)propanoic acid (CAS: 28024-60-4) represents a valuable chemical entity with diverse applications in medicinal chemistry. The growing body of research on this compound underscores its potential as a versatile scaffold for drug discovery and development. Future studies should focus on translating these findings into clinically relevant therapeutics while addressing the current limitations in drug-like properties.

28024-60-4 (2-amino-3-(1H-pyrazol-1-yl)propanoic acid) Related Products

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Amadis Chemical Company Limited
(CAS:28024-60-4)2-amino-3-(1H-pyrazol-1-yl)propanoic acid
A876799
Purity:99%
Quantity:1g
Price ($):368.0
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