Cas no 27746-99-2 (2,2,2-trifluoroethyl chloroformate)
2,2,2-Trifluoroethyl chloroformate is a highly reactive acylating agent commonly employed in organic synthesis and peptide chemistry. Its trifluoroethyl group enhances electrophilicity, facilitating efficient acylation reactions under mild conditions. This compound is particularly useful for introducing protecting groups or activating carboxylic acids in the synthesis of complex molecules. The presence of fluorine atoms contributes to improved stability and selectivity in certain transformations. It is often utilized in the preparation of pharmaceuticals, agrochemicals, and specialty materials. Proper handling is essential due to its moisture sensitivity and potential corrosivity. The reagent is typically stored under inert conditions to maintain purity and reactivity.
27746-99-2 structure
Product Name:2,2,2-trifluoroethyl chloroformate
CAS No:27746-99-2
MF:C3H2ClF3O2
MW:162.494990825653
MDL:MFCD00800932
CID:251384
PubChem ID:2769648
Update Time:2025-06-29
2,2,2-trifluoroethyl chloroformate Chemical and Physical Properties
Names and Identifiers
-
- Carbonochloridic acid,2,2,2-trifluoroethyl ester
- 2,2,2-Trifluoroethyl Chloroformate
- 2,2,2-Trifluoroethyl carbonochloridate
- 2,2,2-trifluoroethyl chloridocarbonate
- 27746-99-2
- AKOS005363021
- SCHEMBL1990762
- 2, 2, 2-trifluoroethyl carbonochloridate
- C77575
- MFCD00800932
- Carbonochloridic acid, 2,2,2-trifluoroethyl ester
- trifluoroethyl chloroformate
- 2,2,2-trifluoroethylcarbonochloridate
- EN300-31105
- BS-13054
- J-016875
- DTXSID10377816
- 2,2,2-trifluoroethoxycarbonyl chloride
- F2147-1612
- DB-239399
- STL134909
- 2,2,2-trifluoroethyl chloroformate
-
- MDL： MFCD00800932
- Inchi： 1S/C3H2ClF3O2/c4-2(8)9-1-3(5,6)7/h1H2
- InChI Key： UJZBSAONPRVEIJ-UHFFFAOYSA-N
- SMILES： ClC(=O)OCC(F)(F)F
Computed Properties
- Exact Mass: 161.9695415g/mol
- Monoisotopic Mass: 161.9695415g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 9
- Rotatable Bond Count: 3
- Complexity: 110
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.3
- Topological Polar Surface Area: 26.3?2
2,2,2-trifluoroethyl chloroformate Security Information
- Hazardous Material transportation number：3277
- Hazard Category Code： 23/24/25-34
- Safety Instruction： 26-36/37/39
2,2,2-trifluoroethyl chloroformate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | T790220-1g |
2,2,2-Trifluoroethyl Chloroformate |
27746-99-2 | 1g |
$ 165.00 | 2022-06-02 | ||
| TRC | T790220-10g |
2,2,2-Trifluoroethyl Chloroformate |
27746-99-2 | 10g |
$ 1300.00 | 2022-06-02 | ||
| Apollo Scientific | PC99157-250mg |
2,2,2-Trifluoroethyl chloroformate |
27746-99-2 | 95% | 250mg |
￡70.00 | 2023-09-02 | |
| Apollo Scientific | PC99157-1g |
2,2,2-Trifluoroethyl chloroformate |
27746-99-2 | 95% | 1g |
￡231.00 | 2023-09-02 | |
| eNovation Chemicals LLC | Y1056148-10g |
2,2,2-trifluoroethyl chloridocarbonate |
27746-99-2 | 95% | 10g |
$685 | 2024-07-28 | |
| TRC | T790220-1000mg |
2,2,2-Trifluoroethyl Chloroformate |
27746-99-2 | 1g |
$201.00 | 2023-05-17 | ||
| TRC | T790220-10000mg |
2,2,2-Trifluoroethyl Chloroformate |
27746-99-2 | 10g |
$1568.00 | 2023-05-17 | ||
| Enamine | EN300-31105-0.05g |
2,2,2-trifluoroethyl carbonochloridate |
27746-99-2 | 95.0% | 0.05g |
$64.0 | 2025-03-19 | |
| Enamine | EN300-31105-0.1g |
2,2,2-trifluoroethyl carbonochloridate |
27746-99-2 | 95.0% | 0.1g |
$96.0 | 2025-03-19 | |
| Enamine | EN300-31105-0.25g |
2,2,2-trifluoroethyl carbonochloridate |
27746-99-2 | 95.0% | 0.25g |
$136.0 | 2025-03-19 |
2,2,2-trifluoroethyl chloroformate Related Literature
-
Andrey V. Bogolubsky,Yurii S. Moroz,Pavel K. Mykhailiuk,Yurii V. Dmytriv,Sergey E. Pipko,Liudmyla N. Babichenko,Anzhelika I. Konovets,Andrey Tolmachev RSC Adv. 2015 5 1063
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