Cas no 27687-14-5 (trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid)
Technical Introduction:
trans-4-[(tert-Butoxycarbonylamino)methyl]cyclohexanecarboxylic acid is a versatile intermediate in organic synthesis, particularly valued for its rigid cyclohexane backbone and protected amine functionality. The trans configuration ensures steric stability, while the tert-butoxycarbonyl (Boc) group provides selective deprotection compatibility, making it useful in peptide and medicinal chemistry. Its carboxylic acid moiety allows for further derivatization, enabling applications in linker design or chiral auxiliaries. The compound’s high purity and well-defined stereochemistry contribute to reproducible results in complex syntheses. Suitable for use in pharmaceutical research and fine chemical production, it offers a balance of reactivity and stability under standard conditions.
![trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid structure](https://ossimg.kuujia.com/scimg/28000/27687-14-5x500.png)
27687-14-5 structure
Product Name:trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid
CAS No:27687-14-5
MF:C13H23NO4
MW:257.3260242939
MDL:MFCD00673773
CID:53203
PubChem ID:736918
Update Time:2025-08-05
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid Chemical and Physical Properties
Names and Identifiers
-
- trans-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid
- Boc-(4-aminomethyl)cyclohexane carboxylic acid
- trans-4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic acid
- 1 week
- 3H-IMidazo[4,5-b]pyridine-2-MethanaMine (hydrochloride)(1:2)
- BOC-TRANS-4-(AMINOMETHYL)-CYCLOHEXANE-1-CARBOXYLIC ACID
- trans-4-(Boc-aminomethyl)cyclohexanecarboxylic acid
- BOC-TRANEXAMIC ACID
- BOC-TRANS-4-(AMINOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID
- tran
- trans-4-(N-tert-butoxy-carbonylaminomethyl)cyclohexanecarboxylic acid
- trans-4-[N-(tert-butoxycarbonyl)aminomethyl]cyclohexane-1-carboxylic acid
- Boc-4-Amc-OH
- 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid
- trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid
- 4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
- 4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]cyclohexane-1-carboxylic Acid
- trans-4-{[(tert-butoxycarbo
- trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid
- trans-N-(t-butoxycarbonyl)-4-(aminomethyl)cyclohexylcarboxylic acid
- (1s,4s)-4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
- N-(tert-butoxycarbonyl)-trans-4-(aminomethyl )-1-cyclohexanecarboxylic acid
- SCHEMBL353639
- trans-4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid
- trans-4-{[(t-butoxycarbonyl) amino]methyl}cyclohexanecarboxylic acid
- AKOS001064296
- trans-4-(tert.-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid
- 4-(([(TERT-BUTOXY)CARBONYL]AMINO)METHYL)CYCLOHEXANE-1-CARBOXYLIC ACID
- 162046-58-4
- AZEKNJGFCSHZID-UHFFFAOYSA-N
- MFCD01862289
- 4-[[(tert-butoxycarbonyl)amino]methyl] cyclohexanecarboxylic acid
- Cyclohexanecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-
- Z56887262
- trans-4-(t-butyloxycarbonyl)aminomethylcyclohexylcarboxylic acid
- FT-0679721
- trans-4- (tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid
- cis-4-{[(tert-butoxycarbonyl)amino]methyl}-cyclohexanecarboxylic acid
- 4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic Acid
- A934958
- AKOS005175122
- trans-4-{[(tert-butoxy)carbonylamino]methyl}cyclohexanecarboxylic acid
- F31156
- Oprea1_341039
- (1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid
- trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexane-carboxylic acid
- 4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid
- Trans-4-(t-butoxycarbonylaminomethyl)cyclohexanecarboxylic acid
- TRANS-4-(T-BUTYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID
- AKOS032957128
- cis-(1,1-Dimethylethoxy)carbonyl Tranexamic Acid
- trans-4 (tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid
- trans-4-{[(tert-butoxy)carbonylamino]methyl}cyclohexane carboxylic acid
- SCHEMBL353652
- trans-4-(tert.-butoxycarbonylaminomethyl) cyclohexanecarboxylic acid
- trans-4-[(Boc-amino)methyl]cyclohexanecarboxylic Acid
- 847416-70-0
- trans-4-(tert-butoxycarbonylamino-methyl)cyclohexanecarboxylic acid
- trans-4-(t-butoxycarbonyl)aminomethylcyclohexylcarboxylic acid
- cis-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid
- trans-4-[(tert-Butoxyformamido)methyl]cyclohexanecarboxylic acid
- AC-29648
- (1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;Boc-(4-aminomethyl)cyclohexane carboxylic acid; trans-4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic acid;TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID
- 4-[[(tert-butoxycarbonyl)-amino]methyl]cyclohexanecarboxylic acid
- cyclohexanecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, trans-
- trans-4-(t-butoxycarbonylaminomethyl)cyclohexyl carboxylic acid
- Cis-(4-BOC-Aminomethyl)-cyclohexyl carboxylic acid
- BOC-(4-AMINOMETHYL)-CYCLOHEXANE-CARBOXYLIC ACID
- Trans-4-(t-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid
- N-Boc-trans-4-(aminomethyl)cyclohexanecarboxylic acid
- trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid
- 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid
- FT-0752291
- cis-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid
- Boc-(4-aminomethyl)cyclohexane carboxylic acid;trans-4-(Boc-aminomethyl)cyclohexanecarboxylic Acid
- CS-0127908
- Trans-4-(t-butoxycarbonylamino-methyl)cyclohexanecarboxylic acid
- trans-4-(tert-butoxycarbonylamino-methyl)-cyclo-hexanecarboxylic acid
- SCHEMBL5006161
- A883020
- 4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid
- Boc-trans-4-(aminomethyl)cyclohexanecarboxylic acid
- 4-(([(tert-Butoxy)carbonyl]amino)methyl)-cyclohexane-1-carboxylic acid
- DTXSID601347564
- CS-0127783
- 4-((BOC-amino)methyl)cyclohexanecarboxylic acid
- cis,trans-(1,1-Dimethylethoxy)carbonylTranexamicAcid-13C2,15N
- FT-0667444
- AZEKNJGFCSHZID-AOOOYVTPSA-N
- 4-[[(tert-butoxycarbonyl)-amino]methyl]-cyclohexanecarboxylic acid
- B3253
- trans-4-tert-Butyloxycarbonylaminomethylcyclohexanecarboxylic Acid
- 4-[(Boc-amino)methyl]cyclohexanecarboxylic Acid
- trans-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid
- BS-4733
- cis-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid
- 27687-14-5
- CBA68714
- AB86500
- cis-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid
- Trans-4-tert-butyloxycarbonylaminomethylcyclohexane carboxylic acid
- trans-4-(t-butoxycarbonylaminomethyl)cyclohexylcarboxylic acid
- trans-4-{[(tert-butoxycarbonyl)-amino]methyl}cyclohexanecarboxylic acid
- EN300-99589
- MFCD00673773
- A1-50247
- AZEKNJGFCSHZID-MGCOHNPYSA-N
- 4-(Boc-aminomethyl)cyclohexanecarboxylic Acid
- AS-37069
- CS-M2057
- trans-4-(tert.-butyloxycarbonylaminomethyl) cyclohexanecarboxylic acid
- EN300-157668
- SY042490
- B3251
- Oprea1_175352
- SCHEMBL9885629
- D85968
- SY056643
- 4-[[(tert-butoxycarbonyl)-amino]methyl] cyclohexanecarboxylic acid
- trans-Boc-tranexamic acid
- A848421
- 4-((tert-butoxycarbonylamino)methyl)cyclohexanecarboxylic acid
- SCHEMBL9885051
- (1r,4r)-4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
- Boc-trans-4-Amc-OH
- 4-{[(TERT-BUTOXYCARBONYL)AMINO]METHYL}CYCLOHEXANE-1-CARBOXYLIC ACID
- CHEMBL5308331
- 7-Methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one; 7-Methyl-2-(morpholin-4-yl)-9-[1-(phenylamino)ethyl]pyrido[1,2-a]pyrimidin-4-one
- ALBB-015792
- (1r,4r)-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexane-1-carboxylic acid
- cis-4-[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-cyclohexanecarboxylic Acid
- STK716513
- BBL028866
- DB-102125
- Boc-4-Amc-OH(cis/trans mixture)
- 4-[(Boc-amino)methyl]cyclohexane-1-carboxylic Acid
- DB-012915
-
- MDL： MFCD00673773
- Inchi： 1S/C13H23NO4/c1-13(2,3)18-12(17)14-8-9-4-6-10(7-5-9)11(15)16/h9-10H,4-8H2,1-3H3,(H,14,17)(H,15,16)
- InChI Key： AZEKNJGFCSHZID-UHFFFAOYSA-N
- SMILES： OC(C1CCC(CNC(=O)OC(C)(C)C)CC1)=O
Computed Properties
- Exact Mass: 257.16300
- Monoisotopic Mass: 257.16270821g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 18
- Rotatable Bond Count: 5
- Complexity: 301
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 75.6
- XLogP3: 1.9
Experimental Properties
- Color/Form: White to Yellow Solid
- Melting Point: 133.0 to 137.0 deg-C
- Boiling Point: 410 ℃ at 760 mmHg
- PSA: 75.63000
- LogP: 2.79300
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid Security Information
- Signal Word：Warning
- Hazard Statement： H302;H315;H319;H335
- Warning Statement： P261;P305+P351+P338
- HazardClass：IRRITANT
- Storage Condition：Room temperature
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid Customs Data
- HS CODE：2924299090
- Customs Data：
China Customs Code:
2924299090Overview:
2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, packing
Summary:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 048436-1g |
trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid |
27687-14-5 | 95% | 1g |
￡13.00 | 2022-03-01 | |
| Fluorochem | 048436-5g |
trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid |
27687-14-5 | 95% | 5g |
￡37.00 | 2022-03-01 | |
| Fluorochem | 048436-25g |
trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid |
27687-14-5 | 95% | 25g |
￡169.00 | 2022-03-01 | |
| Fluorochem | 048436-100g |
trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid |
27687-14-5 | 95% | 100g |
￡577.00 | 2022-03-01 | |
| AstaTech | 56598-1/G |
TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID |
27687-14-5 | 97% | 1/G |
$45 | 2021-07-03 | |
| AstaTech | 56598-5/G |
TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID |
27687-14-5 | 97% | 5g |
$27 | 2023-09-17 | |
| AstaTech | 56598-25/G |
TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID |
27687-14-5 | 97% | 25g |
$129 | 2023-09-17 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T162337-25g |
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid |
27687-14-5 | 98% | 25g |
￥556.90 | 2023-08-31 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T162337-5g |
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid |
27687-14-5 | 98% | 5g |
￥220.90 | 2023-08-31 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T162337-1g |
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid |
27687-14-5 | 98% | 1g |
￥123.90 | 2023-08-31 |
trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid Related Literature
-
Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
-
Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
-
Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
-
Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
Additional information on trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid
Trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic Acid: A Key Intermediate in Medicinal Chemistry
Trans-4-[(tert-butoxycarbonylamino)methyl]cyclohexanecarboxylic acid (CAS No. 27687-14-5) represents a pivotal compound in the development of novel therapeutics, particularly in the field of anti-inflammatory and anti-cancer drug discovery. This molecule, characterized by its tert-butoxycarbonyl (Boc) group and cyclohexane ring, serves as a versatile building block for the synthesis of bioactive molecules with potential applications in targeted therapy and signal transduction modulation. Recent advancements in computational chemistry and structure-activity relationship (SAR) analysis have further highlighted its significance in modern pharmaceutical research.
The tert-butoxycarbonyl functionality in this compound plays a critical role in protecting the amino group during synthetic processes. This protection strategy is widely utilized in peptide chemistry and prodrug design, ensuring the stability of the molecule while allowing for controlled release of the active moiety in biological systems. The cyclohexane ring contributes to the molecule's conformational flexibility, enabling it to interact with target proteins in a manner that is both specific and reversible. This property is particularly valuable in the development of enzyme inhibitors and <
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