• 1. Facile synthesis of substituted quinolines by iron(iii)-catalyzed cascade reaction between anilines, aldehydes and nitroalkanes
  Sachinta Mahato,Anindita Mukherjee,Sougata Santra,Grigory V. Zyryanov,Adinath Majee Org. Biomol. Chem. 2019 17 7907
• 2. Organic acid catalysed Minisci-type arylation of heterocycles with aryl acyl peroxides
  Yani Ouyang,Xiaoguang Yue,Jiehai Peng,Jiashun Zhu,Qiuyuan Shen,Wanmei Li Org. Biomol. Chem. 2022 20 6619
• 3. The synthesis of quinolines via denitrogenative palladium-catalyzed cascade reaction of o-aminocinnamonitriles with arylhydrazines
  Jing Xie,Hang Huang,Tong Xu,Renhao Li,Jiuxi Chen,Xueting Ye RSC Adv. 2020 10 8586
• 4. Mild and efficient copper-catalyzed oxidative cyclization of oximes with 2-aminobenzyl alcohols at room temperature: synthesis of polysubstituted quinolines
  Yan-Yun Liu,Yang Wei,Zhi-Hui Huang,Yilin Liu Org. Biomol. Chem. 2021 19 659
• 5. AgNO3-catalyzed direct C–H arylation of quinolines by oxidative decarboxylation of aromatic carboxylic acids
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Phenylquinolines

6-Methyl-2-phenylquinoline (CAS No. 27356-46-3): An Overview of Its Structure, Properties, and Applications in Modern Chemistry

6-Methyl-2-phenylquinoline (CAS No. 27356-46-3) is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, medicinal chemistry, and materials science. This compound belongs to the quinoline family, a class of heterocyclic aromatic compounds known for their diverse biological activities and potential applications in drug development.

The molecular structure of 6-Methyl-2-phenylquinoline consists of a quinoline ring with a methyl group at the 6-position and a phenyl group at the 2-position. The quinoline ring itself is a fused benzene and pyridine ring system, which imparts unique chemical and physical properties to the molecule. The presence of the methyl and phenyl substituents further modulates these properties, making 6-Methyl-2-phenylquinoline an intriguing compound for various research and industrial applications.

In terms of physical properties, 6-Methyl-2-phenylquinoline is typically a solid at room temperature with a melting point ranging from 100 to 105°C. It is slightly soluble in water but exhibits good solubility in organic solvents such as ethanol, methanol, and dichloromethane. These solubility characteristics make it suitable for use in various chemical reactions and analytical techniques.

The chemical reactivity of 6-Methyl-2-phenylquinoline is influenced by its electronic structure. The quinoline ring system is electron-rich, which makes it susceptible to electrophilic substitution reactions. Additionally, the presence of the phenyl group at the 2-position can influence the reactivity of the molecule by providing steric hindrance or electronic effects. These properties have been exploited in synthetic chemistry to develop novel derivatives and analogs with enhanced functionalities.

In the realm of medicinal chemistry, 6-Methyl-2-phenylquinoline has shown promise as a lead compound for drug discovery. Recent studies have demonstrated its potential as an inhibitor of various enzymes and receptors involved in disease pathways. For instance, research published in the Journal of Medicinal Chemistry reported that derivatives of 6-Methyl-2-phenylquinoline exhibit potent anti-inflammatory and anti-cancer activities. These findings highlight the compound's potential as a scaffold for developing new therapeutic agents.

Beyond its medicinal applications, 6-Methyl-2-phenylquinoline has also found use in materials science. Its unique electronic properties make it an attractive candidate for the development of organic semiconductors and photovoltaic materials. Studies have shown that derivatives of this compound can be used to enhance the performance of organic solar cells by improving charge transport and stability. This application area is particularly relevant given the growing interest in sustainable energy solutions.

The synthesis of 6-Methyl-2-phenylquinoline can be achieved through various routes, including Povarov reactions and palladium-catalyzed cross-coupling reactions. These methods offer high yields and good functional group tolerance, making them suitable for large-scale production. Recent advancements in synthetic methodologies have further optimized these processes, reducing reaction times and improving overall efficiency.

In conclusion, 6-Methyl-2-phenylquinoline (CAS No. 27356-46-3) is a multifaceted compound with a wide range of applications in modern chemistry. Its unique structural features and chemical properties make it an invaluable tool for researchers in fields such as organic synthesis, medicinal chemistry, and materials science. As ongoing research continues to uncover new possibilities, the future prospects for this compound are promising.

• 23746-81-8(2-(2-Naphthyl)indole)
• 4789-76-8(4-Methyl-2-phenylquinoline)
• 5353-90-2(8-Methyl-2-phenylquinoline)
• 3297-72-1(1-Phenylisoquinoline)
• 612-96-4(2-Phenylquinoline)
• 21470-37-1(2-Biphenyl-4-yl-1H-indole)
• 948-65-2(2-phenyl-1H-indole)
• 27356-39-4(7-Methyl-2-phenylquinoline)
• 13228-36-9(5-Methyl-2-phenylindole)
• 2720-93-6(Phenanthridine,6-phenyl-)