Cas no 27106-49-6 (1-(4-fluorobenzenesulfonyl)piperazine)

1-(4-Fluorobenzenesulfonyl)piperazine is a fluorinated sulfonamide derivative with a piperazine core, commonly utilized as a versatile intermediate in organic synthesis and pharmaceutical research. Its key structural features include a sulfonyl group linked to a fluorinated aromatic ring, enhancing its reactivity and potential for further functionalization. The compound is particularly valuable in the development of bioactive molecules, owing to its ability to act as a building block for sulfonamide-based pharmacophores. The fluorine substituent contributes to improved metabolic stability and binding affinity in target compounds. This reagent is typically employed in medicinal chemistry for the synthesis of potential therapeutic agents, including enzyme inhibitors and receptor modulators.

1-(4-fluorobenzenesulfonyl)piperazine structure

27106-49-6 structure

Product Name:1-(4-fluorobenzenesulfonyl)piperazine

CAS No:27106-49-6

MF:C₁₀H₁₃FN₂O₂S

MW:244.285824537277

MDL:MFCD00227560

CID:239478

PubChem ID:2063342

Update Time:2025-05-24

1-(4-fluorobenzenesulfonyl)piperazine Chemical and Physical Properties

Names and Identifiers

- 1-((4-Fluorophenyl)sulfonyl)piperazine
- 1-(4-Fluoro-benzenesulfonyl)-piperazine
- Piperazine,1-[(4-fluorophenyl)sulfonyl]-
- 1-[(4-fluorophenyl)sulfonyl]piperazine
- 4-fluoro-1-(piperazinylsulfonyl)benzene
- AC1M145R
- AC1Q4MBM
- Oprea1_470585
- Oprea1_779023
- SureCN1797016
- 1-(4-fluorobenzenesulfonyl)piperazine
- CS-0038305
- MS-0986
- Z56953052
- AKOS000264224
- DTXSID40366238
- 27106-49-6
- BB 0220639
- 1-(4-fluorophenyl)sulfonylpiperazine
- 1-(4-fluorophenylsulfonyl)piperazine
- SCHEMBL1797016
- CHEMBL1940806
- MFCD00227560
- EN300-08273
- ALBB-001517
- STK347667
- MDL： MFCD00227560
- Inchi： 1S/C10H13FN2O2S/c11-9-1-3-10(4-2-9)16(14,15)13-7-5-12-6-8-13/h1-4,12H,5-8H2
- InChI Key： KKDHOKJGLSITHN-UHFFFAOYSA-N
- SMILES： S(C1C=CC(=CC=1)F)(N1CCNCC1)(=O)=O

Computed Properties

Exact Mass: 244.06829
Monoisotopic Mass: 244.06817700g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 16
Rotatable Bond Count: 2
Complexity: 314
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 0.5
Topological Polar Surface Area: 57.8?2

Experimental Properties

PSA: 49.41

1-(4-fluorobenzenesulfonyl)piperazine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Fluorochem	033331-1g	1-(4-Fluoro-benzenesulfonyl)-piperazine	27106-49-6	95%	1g	￡44.00	2022-02-28
Fluorochem	033331-5g	1-(4-Fluoro-benzenesulfonyl)-piperazine	27106-49-6	95%	5g	￡188.00	2022-02-28
Fluorochem	033331-25g	1-(4-Fluoro-benzenesulfonyl)-piperazine	27106-49-6	95%	25g	￡674.00	2022-02-28
Chemenu	CM113589-5g	1-[(4-fluorophenyl)sulfonyl]piperazine	27106-49-6	95%	5g	$600	2021-08-06
Chemenu	CM113589-10g	1-[(4-fluorophenyl)sulfonyl]piperazine	27106-49-6	95%	10g	$960	2021-08-06
Alichem	A019091193-5g	1-(4-Fluoro-benzenesulfonyl)-piperazine	27106-49-6	98%	5g	$337.84	2023-09-02
Alichem	A019091193-25g	1-(4-Fluoro-benzenesulfonyl)-piperazine	27106-49-6	98%	25g	$973.17	2023-09-02
ChemScence	CS-0038305-1g	1-((4-Fluorophenyl)sulfonyl)piperazine	27106-49-6		1g	$102.0	2022-04-27
ChemScence	CS-0038305-5g	1-((4-Fluorophenyl)sulfonyl)piperazine	27106-49-6		5g	$381.0	2021-09-02
TRC	F596708-100mg	1-(4-Fluoro-benzenesulfonyl)-piperazine	27106-49-6		100mg	$ 64.00	2023-04-15

1-(4-fluorobenzenesulfonyl)piperazine Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:27106-49-6)1-(4-fluorobenzenesulfonyl)piperazine

Order Number:A1084646

Stock Status:in Stock

Quantity:5g

Purity:99%

Pricing Information Last Updated:Thursday, 29 August 2024 19:22

Price ($):200.0

Email:[email protected]

Product Official Link

1-(4-fluorobenzenesulfonyl)piperazine Related Literature

1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?

Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?

Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
3. Enabling chloride salts for thermal energy storage: implications of salt purity?

J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
4. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet

Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
5. Emerging enantiomeric resolution materials with homochiral nano-fabrications

Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

Additional information on 1-(4-fluorobenzenesulfonyl)piperazine

1-(4-Fluorobenzenesulfonyl)piperazine: A Comprehensive Overview

1-(4-Fluorobenzenesulfonyl)piperazine, also known by its CAS number 27106-49-6, is a versatile organic compound that has garnered significant attention in the fields of pharmaceutical chemistry and materials science. This compound, characterized by its unique structure featuring a piperazine ring attached to a sulfonyl group substituted with a fluorine atom, exhibits a wide range of applications and properties that make it a valuable component in various chemical processes.

The synthesis of 1-(4-fluorobenzenesulfonyl)piperazine typically involves multi-step reactions, often starting with the preparation of the sulfonyl chloride intermediate. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing the overall cost and improving the scalability of production. The compound's structure allows for further functionalization, making it an ideal building block for constructing more complex molecules with tailored properties.

In terms of applications, 1-(4-fluorobenzenesulfonyl)piperazine has been extensively studied for its potential in drug discovery. Its ability to act as a bioisostere or a scaffold for medicinal compounds has been highlighted in several recent studies. For instance, researchers have explored its role in developing inhibitors for various enzymes, including kinases and proteases, which are critical targets in oncology and infectious diseases.

The pharmacokinetic profile of 1-(4-fluorobenzenesulfonyl)piperazine is another area of active investigation. Studies have shown that the compound exhibits moderate solubility and permeability, which are essential for oral bioavailability. However, its stability under physiological conditions remains a challenge, prompting further research into strategies to enhance its half-life without compromising its efficacy.

From a materials science perspective, 1-(4-fluorobenzenesulfonyl)piperazine has been evaluated as a precursor for advanced materials such as polymers and coordination networks. Its ability to form hydrogen bonds and engage in π-π interactions makes it suitable for applications in molecular recognition and sensing technologies.

In conclusion, 1-(4-fluorobenzenesulfonyl)piperazine, with its CAS number 27106-49-6, stands as a pivotal compound in contemporary chemical research. Its diverse applications, coupled with ongoing advancements in synthesis and application development, underscore its importance as a key player in both academic and industrial settings.

27106-49-6 (1-(4-fluorobenzenesulfonyl)piperazine) Related Products

Recommended suppliers