• 1. Achieving excellent anti-corrosion and tribological performance by tailoring the surface morphology and chemical composition of aluminum alloys
  Wenjie Zhao,Hua Hou,Yuchun Jin,Zhixiang Zeng,Xuedong Wu,Qunji Xue RSC Adv., 2014,4, 60307-60315
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 3. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 4. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960
• 5. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210

Professional Introduction to 4-Aminopyridine-2,6-dicarboxylic acid (CAS No: 2683-49-0)

4-Aminopyridine-2,6-dicarboxylic acid, with the chemical formula C?H?N?O?, is a significant compound in the field of pharmaceutical and biochemical research. This heterocyclic organic compound features a pyridine core with two carboxylic acid groups and an amino group, making it a versatile building block for various synthetic applications. Its unique structural properties have garnered attention in the development of novel therapeutic agents and catalysts.

The compound is primarily recognized for its role as an intermediate in the synthesis of more complex molecules. Its dual functionality allows for the formation of stable coordination complexes with metals, which has implications in catalysis and material science. Additionally, the presence of both amino and carboxylic acid groups enables its incorporation into polymers and functional materials, further expanding its utility.

In recent years, 4-Aminopyridine-2,6-dicarboxylic acid has been extensively studied for its potential applications in drug discovery. Researchers have leveraged its structural motif to design inhibitors targeting various biological pathways. For instance, derivatives of this compound have shown promise in inhibiting enzymes involved in cancer metabolism. The carboxylic acid groups facilitate hydrogen bonding interactions with biological targets, while the amino group allows for further modifications to enhance binding affinity.

One notable area of research involves the use of 4-Aminopyridine-2,6-dicarboxylic acid in the development of metal-organic frameworks (MOFs). These frameworks are highly porous materials that can be tailored for specific applications such as gas storage, separation technologies, and drug delivery systems. The compound’s ability to act as a ligand in MOF synthesis has led to the creation of novel materials with enhanced stability and selectivity.

Moreover, the pharmaceutical industry has explored 4-Aminopyridine-2,6-dicarboxylic acid as a precursor in the synthesis of antiviral and antibacterial agents. Its structural features allow for interactions with viral proteases and bacterial enzymes, making it a valuable scaffold for medicinal chemistry efforts. Recent studies have highlighted its role in developing protease inhibitors that target pathogens responsible for emerging infectious diseases.

The compound’s versatility also extends to its use in bioconjugation chemistry. Researchers have utilized 4-Aminopyridine-2,6-dicarboxylic acid to link biomolecules such as antibodies and peptides with imaging agents or therapeutic payloads. This approach has enabled the development of targeted therapies where precision delivery is critical. The carboxylic acid groups serve as attachment points for functional moieties, while the amino group ensures proper orientation and stability.

In material science, 4-Aminopyridine-2,6-dicarboxylic acid has been employed to create conductive polymers and organic semiconductors. Its ability to form stable coordination complexes with transition metals enhances electron transport properties, making it suitable for applications in electronic devices. These advancements underscore the compound’s broad applicability beyond traditional pharmaceuticals.

The synthesis of 4-Aminopyridine-2,6-dicarboxylic acid typically involves multi-step organic reactions starting from commercially available precursors. Advances in synthetic methodologies have improved yield and purity, making it more accessible for research purposes. Techniques such as catalytic hydrogenation and oxidation play crucial roles in constructing its core structure.

Regulatory considerations are an essential aspect when handling 4-Aminopyridine-2,6-dicarboxylic acid. While it is not classified as a hazardous substance under standard guidelines, proper handling procedures must be followed to ensure safety in laboratory settings. Storage conditions should be controlled to prevent degradation, and personal protective equipment (PPE) is recommended during handling.

The future prospects of 4-Aminopyridine-2,6-dicarboxylic acid are promising, with ongoing research exploring new synthetic pathways and applications. Collaborative efforts between academia and industry are expected to drive innovation in utilizing this compound for advanced materials and therapeutics. As our understanding of its properties evolves, so too will its role in addressing global challenges in medicine and technology.

• 749900-74-1(3-Amino-5-methyl-1H-pyrrole-2-carboxylic acid)
• 1197-10-0(6-(Hydroxymethyl)picolinic acid)
• 71469-93-7(Methyl 4-aminopyridine-2-carboxylate)
• 100047-36-7(4-Aminopyridine-2-carboxylic acid)
• 24242-20-4(5-Aminopicolinic Acid)
• 114849-40-0(2-Pyridinecarboxylicacid, 5-amino-, labeled with tritium (9CI))
• 499-83-2(Pyridine-2,6-dicarboxylic acid)
• 23609-89-4(2-Pyridinecarboxylicacid, 4-amino-5-methyl-)
• 150730-41-9(2,6-Pyridinedicarboxylicacid, 4-amino-, 2,6-dimethyl ester)
• 155815-95-5(4-Amino-1H-pyrrole-2-carboxylic acid)