• 1. A molecular electron density theory study of the higher-order cycloaddition reactions of tropone with electron-rich ethylenes. The role of the Lewis acid catalyst in the mechanism and pseudocyclic selectivity
  Luis R. Domingo,Patricia Pérez New J. Chem. 2022 46 294
• 2. Reactivity of 2-acylaminoacrylates with ketene diethyl acetal; [2 + 2] cycloadditions vs. tandem condensations
  Alberto Avenoza,Jesús H. Busto,Noelia Canal,Jesús M. Peregrina Chem. Commun. 2003 1376
• 3. Mechanistic study of the ring-size modulation in Michael–Dieckmann type reactions of 2-acylaminoacrylates with ketene diethyl acetal
  Alberto Avenoza,Jesús H. Busto,Noelia Canal,José I. García,Gonzalo Jiménez-Osés,Jesús M. Peregrina,Marta Pérez-Fernández New J. Chem. 2007 31 224
• 4. A comprehensive study of [2?+?2] cycloadditions and ene reactions of alkynyl chromium and tungsten carbene complexes with enol ethers and ketene acetals and of the stereochemistry of the electrocyclic ring opening of cyclobutenyl carbene complexes
  William D. Wulff,Katherine L. Faron,Jing Su,James P. Springer,Arnold L. Rheingold J. Chem. Soc. Perkin Trans. 1 1999 197
• 5. Reaction of ketenes. Part 18. Catalysed reactions between α-diazocarbonyl compounds and ketene acetals
  M. Liliana Graziano,Rachele Scarpati J. Chem. Soc. Perkin Trans. 1 1985 289

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketene acetals

Professional Introduction to Compound with CAS No. 2678-54-8 and Product Name: 1,1-Diethoxyethene

1,1-Diethoxyethene, identified by the Chemical Abstracts Service Number (CAS No.) 2678-54-8, is a significant compound in the realm of organic chemistry and pharmaceutical research. This compound, featuring a unique ethylene backbone with two ethoxy groups, has garnered attention due to its versatile reactivity and potential applications in synthetic chemistry and medicinal chemistry. The molecular structure of 1,1-Diethoxyethene consists of a central carbon atom double-bonded to another carbon, each of which is further substituted with an ethoxy group (-OCH?CH?). This configuration imparts distinct chemical properties that make it a valuable intermediate in various synthetic pathways.

The chemical behavior of 1,1-Diethoxyethene is largely influenced by the presence of its ethoxy substituents. These groups not only enhance the compound's solubility in polar solvents but also participate in nucleophilic substitution reactions, making it a useful building block for more complex molecules. In recent years, researchers have been exploring the utility of 1,1-Diethoxyethene in the synthesis of bioactive compounds, particularly those targeting neurological and inflammatory disorders. The compound's ability to undergo facile functionalization has opened new avenues for drug discovery.

One of the most compelling aspects of 1,1-Diethoxyethene is its role as a precursor in the synthesis of more complex heterocyclic compounds. Heterocycles are widely recognized for their pharmacological significance, with many drugs on the market containing heterocyclic moieties. The introduction of ethoxy groups into these structures can modulate their biological activity, making them more effective or selective in targeting specific receptors or enzymes. For instance, derivatives of 1,1-Diethoxyethene have been investigated for their potential as kinase inhibitors, which are crucial in treating cancers and inflammatory diseases.

Recent advancements in computational chemistry have further highlighted the importance of 1,1-Diethoxyethene in drug design. Molecular modeling studies have demonstrated that small modifications to its structure can significantly alter its binding affinity to biological targets. This has led to the development of novel computational tools that predict the efficacy of 1,1-Diethoxyethene derivatives before they are synthesized in the lab. Such innovations are accelerating the pace of drug discovery by reducing the time and resources required for experimental validation.

The industrial applications of 1,1-Diethoxyethene extend beyond pharmaceuticals. In materials science, this compound has been explored as a monomer for polymerization reactions. The resulting polymers exhibit unique properties such as thermal stability and chemical resistance, making them suitable for use in high-performance coatings and adhesives. Additionally, 1,1-Diethoxyethene has been utilized in the synthesis of specialty chemicals used in fragrances and flavors due to its ability to form stable esters and other functionalized derivatives.

In environmental chemistry, the study of 1,1-Diethoxyethene has provided insights into green chemistry principles. Researchers have developed catalytic systems that allow for the efficient conversion of this compound into other useful products with minimal waste generation. Such efforts align with global initiatives aimed at reducing the environmental impact of chemical manufacturing processes. The development of sustainable synthetic routes for 1,1-Diethoxyethene not only enhances its economic viability but also contributes to a more sustainable chemical industry.

The future prospects for 1,1-Diethoxyethene are promising, with ongoing research uncovering new applications and refining existing ones. As our understanding of its chemical properties continues to grow, so does its potential to contribute to advancements in medicine, materials science, and environmental technology. Collaborative efforts between academia and industry are essential to fully realize these opportunities and ensure that 1,1-Diethoxyethene remains at the forefront of scientific innovation.

• 40923-93-1(Tetraethoxyethene)
• 27613-77-0(Poly(oxy-1,2-ethanediyl),a-acetyl-w-hydroxy-)
• 4362-23-6(2-methylidene-1,3-dioxolane)
• 69814-56-8(2-Methylene-1,3-dioxepane)
• 21504-43-8(1-propene, 1,1-diethoxy-)
• 773848-07-0(Ethenol,1-(1-methylethoxy)-)
• 105649-50-1(2-methylidene-1,3,6-trioxocane)
• 85152-89-2(tetraethoxyallene)
• 10284-51-2(Butane, 1,1'-[ethenylidenebis(oxy)]bis-)
• 741625-37-6(1-Propen-1-ol,1-ethoxy-)