Cas no 2642-37-7 (3-Indoxyl Sulfate Potassium Salt)
3-Indoxyl Sulfate Potassium Salt Chemical and Physical Properties
Names and Identifiers
-
- Potassium 1H-indol-3-yl sulfate
- 3-Indoxyl Sulfate Potassium Salt
- Indoxyl sulfate potassium salt
- 3-indolyl hydrogen sulfate potassium salt
- EINECS 220-145-5
- Indol-3-ol,potassium sulfate
- Indol-3-yl potassium sulfate
- Indol-3-yl sulfate,potassium salt
- Potassium indol-3-yl sulfate
- Potassium indol-3-yl sulphate
- Schwefelsaeure-mono-indol-3-ylester,Kalium-Verbindung
- sulfuric acid mono-indol-3-yl ester,potassium-compound
- Urinary indican
- Indol-3-ol, potassium sulfate
- Indol-3-yl sulfate, potassium salt
- 3-hydroxyindol
- Potassium indoxyl sulfate
- MDAWATNFDJIBBD-UHFFFAOYSA-M
- 1346601-03-3
- UNII-567HMW942W
- Z3020640133
- 3-Indoxyl sulfate, potassium salt
- INDOL-3-OL, HYDROGEN SULFATE (ester), POTASSIUM SALT
- FD10016
- C8H6KNO4S
- POTASSIUM,1H-INDOL-3-YL SULFATE
- 567HMW942W
- 3-Indoxylsulfuric acid, potassium salt
- 1H-Indol-3-ol,3-(hydrogen sulfate), potassium salt (1:1)
- CS-W012626
- Indican (urinary)
- HY-W011910
- AKOS016003133
- FT-0615879
- SR-01000642319-1
- SCHEMBL10550536
- 2642-37-7
- A852055
- Potassium 3-indoxyl sulfate
- 1H-Indol-3-ol, 3-(hydrogen sulfate), potassium salt (1:1)
- EN300-1266343
- 3-Indoxyl Sulfate-d4 Potassium Salt
- CHEMBL1452061
- Q27261386
- INDOXYL SULFATE POTASSIUM SALT [MI]
- Potassium 3-Indolyl Sulfate
- SMR000875350
- I-6350
- MFCD00037931
- DTXSID70181012
- CCG-53133
- NS00074176
- AKOS024306954
- MLS001361369
- potassium1H-indol-3-ylsulfate
- SY106394
- potassium;1H-indol-3-yl sulfate
- DB-046950
-
- MDL： MFCD00037931
- Inchi： 1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1
- InChI Key： MDAWATNFDJIBBD-UHFFFAOYSA-M
- SMILES： [K+].S(=O)(=O)([O-])OC1=CNC2C=CC=CC=21
- BRN： 3921324
Computed Properties
- Exact Mass: 250.96500
- Monoisotopic Mass: 250.965
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 15
- Rotatable Bond Count: 2
- Complexity: 302
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 90.6A^2
Experimental Properties
- Color/Form: Pale yellow
- Melting Point: 165?°C (dec.) (lit.)
- Boiling Point: °Cat760mmHg
- Flash Point: °C
- PSA: 90.60000
- LogP: 2.08770
- Solubility: Not available
- Sensitiveness: Light Sensitive
3-Indoxyl Sulfate Potassium Salt Security Information
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Safety Instruction： S22-S24/25
- FLUKA BRAND F CODES：8-10-23
- RTECS：NM3200000
- Storage Condition：?20°C
3-Indoxyl Sulfate Potassium Salt Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
3-Indoxyl Sulfate Potassium Salt Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | I3875-250MG |
3-Indoxyl Sulfate Potassium Salt |
2642-37-7 | 250MG |
1065.9 | 2021-05-17 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | I3875-1G |
3-Indoxyl Sulfate Potassium Salt |
2642-37-7 | 1G |
1967.27 | 2021-05-17 | ||
| Matrix Scientific | 093856-1g |
Potassium 1H-indol-3-yl sulfate, 97% |
2642-37-7 | 97% | 1g |
$341.00 | 2023-09-09 | |
| Matrix Scientific | 093856-5g |
Potassium 1H-indol-3-yl sulfate, 97% |
2642-37-7 | 97% | 5g |
$975.00 | 2023-09-09 | |
| Fluorochem | 222801-1g |
Potassium 1H-indol-3-yl sulfate |
2642-37-7 | 95% | 1g |
￡117.00 | 2022-03-01 | |
| Fluorochem | 222801-5g |
Potassium 1H-indol-3-yl sulfate |
2642-37-7 | 95% | 5g |
￡503.00 | 2022-03-01 | |
| Fluorochem | 222801-10g |
Potassium 1H-indol-3-yl sulfate |
2642-37-7 | 95% | 10g |
￡961.00 | 2022-03-01 | |
| TRC | I655630-250mg |
3-Indoxyl Sulfate Potassium Salt |
2642-37-7 | 250mg |
105.00 | 2021-08-04 | ||
| TRC | I655630-500mg |
3-Indoxyl Sulfate Potassium Salt |
2642-37-7 | 500mg |
160.00 | 2021-08-04 | ||
| TRC | I655630-1g |
3-Indoxyl Sulfate Potassium Salt |
2642-37-7 | 1g |
240.00 | 2021-08-04 |
3-Indoxyl Sulfate Potassium Salt Suppliers
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3-Indoxyl Sulfate Potassium Salt Related Literature
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Rastislav Mono?ík,Lars Ove Dragsted Anal. Methods 2016 8 6865
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Shun Yu,Mirjam Schuchardt,Markus T?lle,Markus van der Giet,Walter Zidek,Joachim Dzubiella,Matthias Ballauff RSC Adv. 2017 7 27913
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Fátima Guerrero,Victoria Pulido,Said Hamad,Pedro Aljama,Alejandro Martín-Malo,Carolina Carrillo-Carrión Nanoscale 2022 14 17543
Additional information on 3-Indoxyl Sulfate Potassium Salt
Latest Research Insights on 3-Indoxyl Sulfate Potassium Salt (CAS: 2642-37-7)
3-Indoxyl Sulfate Potassium Salt (CAS: 2642-37-7) is a significant metabolite derived from the breakdown of tryptophan by gut microbiota. Recent studies have highlighted its role as a uremic toxin and its implications in chronic kidney disease (CKD), cardiovascular diseases, and neurological disorders. This research briefing synthesizes the latest findings on its biochemical properties, mechanisms of action, and potential therapeutic applications.
A 2023 study published in the Journal of Biochemical and Molecular Toxicology demonstrated that 3-Indoxyl Sulfate Potassium Salt exacerbates oxidative stress and inflammation in renal tubular cells, contributing to CKD progression. Researchers employed in vitro models using HK-2 cells treated with varying concentrations of the compound, revealing dose-dependent increases in reactive oxygen species (ROS) and pro-inflammatory cytokines such as IL-6 and TNF-α. These findings underscore its role in renal fibrosis and suggest potential targets for therapeutic intervention.
In the context of cardiovascular health, a 2024 meta-analysis in Circulation Research linked elevated serum levels of 3-Indoxyl Sulfate Potassium Salt to endothelial dysfunction and atherosclerosis. The study analyzed data from over 5,000 patients, showing a strong correlation between this metabolite and arterial stiffness, independent of traditional risk factors. Mechanistic studies identified its ability to inhibit nitric oxide synthase (NOS), thereby impairing vasodilation and promoting vascular calcification.
Emerging research also explores its neurotoxic potential. A preclinical study in Neurochemistry International (2024) reported that 3-Indoxyl Sulfate Potassium Salt crosses the blood-brain barrier and induces microglial activation, leading to neuroinflammation and cognitive decline in murine models. This aligns with clinical observations of higher metabolite levels in patients with neurodegenerative conditions like Alzheimer’s disease.
On the analytical front, advancements in detection methods have been pivotal. A 2023 Analytical Chemistry paper introduced a high-performance liquid chromatography (HPLC) protocol with mass spectrometry (MS) detection, achieving picomolar sensitivity for 3-Indoxyl Sulfate Potassium Salt quantification in biological matrices. This method facilitates precise monitoring in clinical and research settings.
In summary, 3-Indoxyl Sulfate Potassium Salt (2642-37-7) remains a focal point in understanding the gut-organ axis and its pathological consequences. Future research directions include exploring gut microbiota modulation to reduce its production and developing targeted therapies to mitigate its toxic effects. These insights are critical for advancing precision medicine in metabolic and degenerative diseases.
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