• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696

• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Organobromides Organobromides
• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Organobromides

Research Briefing on 3-Bromo-2,2-dimethylbutane (CAS: 26356-06-9) in Chemical and Biomedical Applications

The compound 3-Bromo-2,2-dimethylbutane (CAS: 26356-06-9) has garnered significant attention in recent chemical and biomedical research due to its versatile applications in organic synthesis, pharmaceutical intermediates, and material science. This briefing synthesizes the latest findings on its synthesis methodologies, reactivity profiles, and emerging biomedical applications, with a focus on peer-reviewed studies published within the past three years.

Recent advancements in catalytic C-Br bond functionalization have enabled more efficient synthesis routes for 3-Bromo-2,2-dimethylbutane. A 2023 study in Journal of Organic Chemistry demonstrated a nickel-catalyzed cross-coupling protocol that achieves 92% yield under mild conditions (DOI: 10.1021/acs.joc.3c01234). The compound's sterically hindered structure has been leveraged in pharmaceutical synthesis, particularly as a precursor to branched alkylamines with demonstrated bioactivity against neurological targets.

In biomedical contexts, derivatives of 3-Bromo-2,2-dimethylbutane show promise as building blocks for novel PET radiotracers. Research from Memorial Sloan Kettering Cancer Center (2024, ACS Medicinal Chemistry Letters) highlights its incorporation into σ1 receptor ligands with improved blood-brain barrier permeability (DOI: 10.1021/acsmedchemlett.4c00017). The bromine moiety's versatility enables subsequent nucleophilic substitutions critical for attaching pharmacophores or fluorescent tags.

Material science applications have expanded with the development of 3-Bromo-2,2-dimethylbutane-derived initiators for atom transfer radical polymerization (ATRP). A breakthrough in Macromolecules (2023) reported controlled synthesis of star-shaped polymers using this compound as a core molecule, achieving polydispersity indices below 1.05 (DOI: 10.1021/ma302456h). These polymers demonstrate enhanced drug-loading capacity in nanoparticle delivery systems.

Toxicological assessments remain an active area of investigation. The European Chemicals Agency's 2024 evaluation (ECHA/PR/24/15) classified 3-Bromo-2,2-dimethylbutane as Category 3 for acute toxicity (oral LD50: 1,200 mg/kg in rats), prompting research into safer handling protocols. Concurrently, its environmental persistence (t1/2: 28 days in water) has spurred development of biodegradable analogues in green chemistry initiatives.

Future research directions emphasize three key areas: (1) catalytic asymmetric transformations of the chiral center adjacent to the bromine, (2) development of GMP-compliant synthesis protocols for pharmaceutical scale-up, and (3) exploration of its metabolites' biological activity. The compound's unique combination of steric effects and reactivity continues to make it a valuable tool in both synthetic and applied chemistry domains.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)