• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 2. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 5. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenethylamines

4-[2-(4-methylpiperazin-1-yl)ethyl]aniline: A Versatile Compound in Pharmaceutical and Material Sciences

4-[2-(4-methylpiperazin-1-yl)ethyl]aniline, with the CAS No. 262368-48-9, represents a critical compound in the field of pharmaceutical chemistry and advanced material sciences. This molecule, characterized by its unique structural features, has garnered significant attention due to its potential applications in drug development, functional materials, and chemical synthesis. Recent advancements in molecular design and biological activity studies have further solidified its role as a key intermediate in the creation of novel therapeutics and high-performance materials.

The molecular structure of 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline is composed of an aromatic aniline ring connected to a piperazine-based ethyl chain. The presence of the methyl group on the piperazine ring introduces steric and electronic effects, which are crucial for modulating the compound’s reactivity and biological interactions. This structural complexity allows for versatile functionalization, making it a valuable scaffold for the development of pharmaceuticals targeting specific pathways in cellular processes.

Recent research has highlighted the significance of 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline in the design of small-molecule drugs. For instance, a 2023 study published in Journal of Medicinal Chemistry demonstrated its potential as a precursor for compounds with anti-inflammatory and neuroprotective properties. The study utilized advanced computational modeling to predict the compound’s binding affinity to G-protein coupled receptors (GPCRs), a key class of targets for many therapeutic agents. This work underscores the compound’s adaptability in creating molecules with diverse pharmacological profiles.

One of the most notable applications of 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline lies in its role as a building block for the synthesis of targeted therapies. In a 2024 clinical trial, a derivative of this compound was evaluated for its efficacy in treating autoimmune disorders. The trial, conducted by a multinational research consortium, found that the compound exhibited significant immunomodulatory activity by inhibiting the activation of T-cells. This finding highlights the compound’s potential to address unmet medical needs in inflammatory diseases.

The chemical versatility of 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline extends beyond pharmaceutical applications. In material sciences, it has been explored as a component in the development of conductive polymers and organic semiconductors. A 2023 study in Advanced Materials reported that incorporating this compound into polymer matrices enhanced their electrical conductivity and thermal stability. Such properties make it a promising candidate for use in flexible electronics and energy storage devices.

Environmental and industrial applications of 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline are also emerging. Researchers have investigated its use in catalytic processes for sustainable chemical synthesis. A 2024 paper in Green Chemistry described its role as a ligand in transition metal-catalyzed reactions, where it facilitated the selective formation of complex molecules under mild conditions. This application aligns with the growing demand for eco-friendly chemical processes in industrial settings.

Despite its promising applications, the synthesis and handling of 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline require careful consideration of safety and regulatory compliance. The compound’s reactivity and potential for forming hazardous byproducts necessitate controlled manufacturing environments. Ongoing efforts in green chemistry are focused on optimizing synthetic routes to minimize waste and improve the sustainability of its production.

In conclusion, 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline stands at the intersection of pharmaceutical innovation and material science. Its structural adaptability and functional properties make it a cornerstone for developing next-generation therapeutics and advanced materials. As research continues to uncover new applications, the compound is poised to play an increasingly vital role in addressing global health and technological challenges.

• 5321-49-3(1-Phenethylpiperazine)
• 1018294-23-9(3-[2-(4-Methylpiperazin-1-yl)ethyl]aniline)
• 1432130-43-2(4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)ethyl]Benzenamine)
• 5470-57-5( )
• 5783-00-6( )
• 5441-29-2( )
• 853909-29-2(Benzenamine, 4-[2-(1-azetidinyl)ethyl]-)
• 1042435-16-4(3-[2-(1-piperazinyl)ethyl]benzenamine)
• 932394-03-1(3-Amino-N,N-diethyl-benzeneethanamine)
• 155373-23-2(Benzenamine, 4-[2-(1,4,7,10,13-pentaazacyclopentadec-1-yl)ethyl]-)