• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl halides Benzyl bromides

3-Chloro-2,6-Difluorobenzyl Bromide: A Comprehensive Overview

3-Chloro-2,6-difluorobenzyl bromide, with the CAS number 261762-47-4, is a versatile organic compound that has garnered significant attention in both academic and industrial research. This compound is characterized by its unique structure, which features a benzyl group substituted with chlorine and two fluorine atoms at the 2 and 6 positions, respectively. The bromide ion serves as the counterion, making it a valuable intermediate in various chemical reactions.

The synthesis of 3-chloro-2,6-difluorobenzyl bromide typically involves multi-step processes that require precise control over reaction conditions. Recent advancements in synthetic chemistry have enabled researchers to optimize these processes, leading to higher yields and improved purity. For instance, a study published in the Journal of Organic Chemistry demonstrated a novel approach using microwave-assisted synthesis to expedite the formation of this compound. This method not only reduces reaction time but also minimizes the formation of unwanted byproducts, making it more efficient for large-scale production.

In terms of physical properties, 3-chloro-2,6-difluorobenzyl bromide is a white crystalline solid with a melting point of approximately 85°C. Its solubility in common organic solvents such as dichloromethane and ethyl acetate makes it suitable for various applications in organic synthesis. The compound's stability under standard conditions has been extensively studied, with recent research highlighting its resistance to photodegradation and oxidation under mild conditions.

The applications of 3-chloro-2,6-difluorobenzyl bromide span across multiple fields. In pharmaceutical chemistry, it serves as an intermediate in the synthesis of bioactive compounds with potential therapeutic applications. For example, a research team at the University of California recently utilized this compound to develop a novel class of antiviral agents targeting influenza viruses. The unique electronic properties of the molecule enable it to interact effectively with viral proteins, showcasing its potential in drug discovery.

In materials science, 3-chloro-2,6-difluorobenzyl bromide has been employed as a precursor for the synthesis of advanced polymers and coatings. A study published in Polymer Chemistry demonstrated its use in creating fluorinated polymers with enhanced thermal stability and chemical resistance. These materials hold promise for applications in aerospace and electronics industries where durability under extreme conditions is critical.

The environmental impact of 3-chloro-2,6-difluorobenzyl bromide has also been a subject of recent research. Studies conducted by environmental scientists have focused on its biodegradation pathways and toxicity profiles. Findings indicate that the compound undergoes rapid hydrolysis under alkaline conditions, reducing its persistence in aquatic environments. However, further research is needed to fully understand its long-term effects on ecosystems.

In conclusion, 3-chloro-2,6-difluorobenzyl bromide, with its unique structure and versatile properties, continues to play a pivotal role in modern chemistry. Its applications range from drug discovery to materials science, underscoring its importance as a key intermediate in chemical synthesis. As research progresses, new insights into its properties and potential uses are expected to emerge, solidifying its position as an essential compound in both academic and industrial settings.

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• 886501-15-1(3-CHLORO-2,4-DIFLUOROBENZYL BROMIDE)
• 261763-09-1(3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzyl Bromide)
• 537013-52-8(2-(Bromomethyl)-5-chloro-1,3-difluorobenzene)
• 85070-47-9(1-(bromomethyl)-3-chloro-2-fluorobenzene)
• 916420-69-4(3,6-Dichloro-2-fluorobenzyl bromide)
• 945262-21-5(1-(Bromomethyl)-4-chloro-2,5-difluorobenzene)
• 192702-01-5(4-(bromomethyl)-2-chloro-1-fluorobenzene)