Cas no 26159-35-3 ((S)-Naproxen Methyl Ester)

(S)-Naproxen Methyl Ester is a chiral intermediate derived from (S)-naproxen, a nonsteroidal anti-inflammatory drug (NSAID). This methyl ester derivative is primarily utilized in pharmaceutical synthesis, offering enhanced solubility and reactivity compared to the parent carboxylic acid. Its stereochemical purity ensures high selectivity in chiral transformations, making it valuable for producing enantiomerically pure APIs. The esterification improves processability in organic solvents, facilitating downstream reactions such as amidation or reduction. As a stable, crystalline solid, it is suitable for controlled storage and handling. This compound is particularly useful in research and industrial applications where precise chirality and efficient derivatization are critical.
(S)-Naproxen Methyl Ester structure
(S)-Naproxen Methyl Ester structure
Product Name:(S)-Naproxen Methyl Ester
CAS No:26159-35-3
MF:C15H16O3
MW:244.285744667053
MDL:MFCD12031841
CID:1062839
PubChem ID:329769059
Update Time:2025-06-07

(S)-Naproxen Methyl Ester Chemical and Physical Properties

Names and Identifiers

    • (S)-Naproxen Methyl Ester
    • (S)-Naproxen Methyl
    • (+)-Naproxen methyl ester
    • 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, methyl ester, (+)-
    • Methyl 2-(6-methoxy-2-naphthyl)propanoate, (S)-
    • Naproxen, methyl deriv.
    • Naproxen, methylated
    • (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester
    • Methyl (αS)-6-methoxy-α-methyl-2-naphthaleneacetate
    • Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
    • Naproxen Impurity E (PhEur)
    • Naproxen Methyl Ester
    • (S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate
    • 571OJX4PDN
    • ZFYFBPCRUQZGJE-JTQLQIEISA-N
    • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, methyl ester, (alphaS)-
    • Methyl (S)-2-(6-Methoxynaphthalen-2-yl)propanoate
    • Naproxen impurity E [EP]
    • Naproxen methyl
    • Monomethyl derivative of Naproxen
    • Naproxen sodium impurity E [EP]
    • Naproxen methyl derivative
    • Naproxen impurity E
    • NS00114067
    • AKOS026674030
    • NAPROXEN SODIUM IMPURITY E [EP IMPURITY]
    • A877350
    • (S)-Methyl2-(6-methoxynaphthalen-2-yl)propanoate
    • DTXSID50180780
    • 2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, METHYL ESTER, (.ALPHA.S)-
    • 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, methyl ester
    • SCHEMBL505819
    • CHEMBL1823699
    • Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate; Naproxen Imp. E (EP); Naproxen Methyl Ester; Naproxen Impurity E
    • RXH
    • AS-72012
    • Methyl 2-(6-methoxy-2-naphthyl)propanoate #
    • (S)-Naproxen methyl ester, pharmaceutical impurity standard
    • MFCD12031841
    • Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate (Naproxen Methyl Ester)
    • Q27261448
    • DB-215286
    • UNII-571OJX4PDN
    • NAPROXEN IMPURITY E [EP IMPURITY]
    • (r,s)-naproxen methyl ester
    • (S)-alpha-methyl-6-methoxy-2-naphthaleneacetic acid methyl ester
    • 26159-35-3
    • A10658
    • MDL： MFCD12031841
    • Inchi： 1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3/t10-/m0/s1
    • InChI Key： ZFYFBPCRUQZGJE-JTQLQIEISA-N
    • SMILES： O(C)C([C@@H](C)C1C=CC2C=C(C=CC=2C=1)OC)=O

Computed Properties

  • Exact Mass: 244.109944368g/mol
  • Monoisotopic Mass: 244.109944368g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 4
  • Complexity: 290
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.1
  • Topological Polar Surface Area: 35.5

Experimental Properties

  • Optical Activity: [α]/D 78±4°, c =?0.1 in chloroform

(S)-Naproxen Methyl Ester Security Information

(S)-Naproxen Methyl Ester Pricemore >>

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