Cas no 2604-39-9 (2-chloro-5-nitro-pyridin-4-amine)

2-Chloro-5-nitro-pyridin-4-amine is a nitro-substituted pyridine derivative featuring both chloro and amino functional groups at adjacent positions. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of reactive sites enables selective functionalization, making it valuable for constructing complex heterocyclic frameworks. Its electron-withdrawing nitro group enhances reactivity in nucleophilic substitution reactions, while the amino group offers opportunities for further derivatization. The compound exhibits stability under standard handling conditions, ensuring reliable performance in synthetic applications. Its well-defined structure and purity make it suitable for research and industrial-scale processes requiring precise molecular modifications.
2-chloro-5-nitro-pyridin-4-amine structure
2604-39-9 structure
Product Name:2-chloro-5-nitro-pyridin-4-amine
CAS No:2604-39-9
MF:C5H4ClN3O2
MW:173.557159423828
MDL:MFCD09033797
CID:43223
PubChem ID:10910058
Update Time:2025-11-06

2-chloro-5-nitro-pyridin-4-amine Chemical and Physical Properties

Names and Identifiers

    • 4-Amino-2-chloro-5-nitropyridine
    • 2-Chloro-5-nitropyridin-4-amine
    • 2-Chloro-4-amino-5-nitropyridine
    • 2-chloro-5-nitropyridine-4-amine
    • 4-Amino-2-chloro-5-nitro-pyridine
    • C5H4ClN3O2
    • 2-chloro-5-nitro-4-pyridinamine
    • 4-PYRIDINAMINE, 2-CHLORO-5-NITRO-
    • 2-chloro-5-nitro-pyridin-4-amine
    • PubChem9316
    • Jsp005126
    • 2-chloro-5-nitro-4-pyridylamine
    • YKWBEPUOVBMENG-UHFFFAOYSA-N
    • 6-Chloro-3-nitropyridine-4-amine
    • 4-Pyridinamine,2-chloro-5-nitro-
    • SBB065522
    • 2-Chloro-5-nitro-pyridin-4-ylamine
    • AKOS006343494
    • SY021513
    • FG-0701
    • F8889-9203
    • A5176
    • PB18957
    • EN300-125506
    • CS-W019655
    • AM20051006
    • FT-0649198
    • SCHEMBL563628
    • CL0272
    • AC-2408
    • Chloro-5-nitropyridin-4-amine
    • 2604-39-9
    • J-508880
    • MFCD09033797
    • DTXSID60448005
    • DB-010110
    • STL557419
    • BBL103609
    • DTXCID30398826
    • MDL： MFCD09033797
    • Inchi： 1S/C5H4ClN3O2/c6-5-1-3(7)4(2-8-5)9(10)11/h1-2H,(H2,7,8)
    • InChI Key： YKWBEPUOVBMENG-UHFFFAOYSA-N
    • SMILES： ClC1=CC(=C(C=N1)[N+](=O)[O-])N

Computed Properties

  • Exact Mass: 172.99900
  • Monoisotopic Mass: 172.9992041g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 0
  • Complexity: 160
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 84.7
  • XLogP3: 1.5

Experimental Properties

  • Color/Form: Pale-yellow to Yellow-brown Solid
  • Density: 1.596
  • Boiling Point: 388.5℃ at 760 mmHg
  • Flash Point: 188.749°C
  • Refractive Index: 1.658
  • PSA: 84.73000
  • LogP: 2.32980

2-chloro-5-nitro-pyridin-4-amine Security Information

2-chloro-5-nitro-pyridin-4-amine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-chloro-5-nitro-pyridin-4-amine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PB03582-1 G
2-chloro-5-nitro-pyridin-4-amine
 2604-39-9 97%
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 ￥ 224.00 2021-05-07
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NAN JING YAO SHI KE JI GU FEN Co., Ltd.
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AstaTech
CL0272-1/G
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AstaTech
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 $14.0 2024-07-28

2-chloro-5-nitro-pyridin-4-amine Production Method

2-chloro-5-nitro-pyridin-4-amine Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:2604-39-9)2-chloro-5-nitro-pyridin-4-amine
Order Number:A5176
Stock Status:in Stock
Quantity:100g/25g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:03
Price ($):1231.0/330.0

2-chloro-5-nitro-pyridin-4-amine Related Literature

Additional information on 2-chloro-5-nitro-pyridin-4-amine

Comprehensive Guide to 2-Chloro-5-nitro-pyridin-4-amine (CAS No. 2604-39-9): Properties, Applications, and Industry Insights

2-Chloro-5-nitro-pyridin-4-amine (CAS No. 2604-39-9) is a specialized nitro-substituted pyridine derivative with significant relevance in pharmaceutical and agrochemical research. This compound, characterized by its chloro and nitro functional groups, serves as a versatile intermediate in synthetic chemistry. Its molecular structure (C5H4ClN3O2) enables diverse reactivity, making it valuable for constructing complex heterocyclic frameworks.

Recent trends highlight growing interest in nitropyridine derivatives due to their role in developing antimicrobial agents and crop protection chemicals. Researchers frequently search for "2-chloro-5-nitro-pyridin-4-amine synthesis" or "CAS 2604-39-9 applications," reflecting demand for sustainable synthetic routes. The compound's electron-withdrawing groups enhance its utility in cross-coupling reactions, a hot topic in green chemistry discussions.

From a technical perspective, 2-chloro-5-nitro-pyridin-4-amine exhibits moderate solubility in polar organic solvents (e.g., DMF, DMSO) but limited water solubility. Its crystalline form typically appears as pale yellow needles, with melting points ranging 145-148??C. Analytical characterization often employs HPLC (retention time ~6.2 min in C18 columns) and LC-MS (m/z 173 [M+H]+). These properties make it distinguishable from related compounds like 2-amino-5-nitropyridine or 4-chloro-3-nitropyridine.

Industrial applications leverage this compound's regioselective reactivity. Pharmaceutical developers utilize it to create potassium channel modulators, while material scientists explore its potential in organic electronic materials. A 2023 study demonstrated its efficacy in synthesizing photoactive dyes for solar cells, aligning with renewable energy trends. This dual applicability addresses frequent search queries like "nitropyridine in drug discovery" and "pyridine derivatives for energy storage."

Quality control protocols for CAS 2604-39-9 emphasize purity verification through 1H NMR (δ 8.35 ppm for aromatic protons) and elemental analysis. Storage recommendations include amber glass containers under inert atmosphere to prevent nitro group reduction – a common degradation pathway. These technical details respond to laboratory professionals searching for "stability of chloronitropyridines" or "handling nitroaromatic compounds."

Emerging research directions explore catalytic amination of 2-chloro-5-nitro-pyridin-4-amine using transition metal complexes, reflecting the industry's shift toward atom-efficient methodologies. Patent analyses reveal increasing use in bioconjugation chemistry, particularly for designing fluorescent probes. These innovations correlate with rising searches for "click chemistry with nitropyridines" and "bioimaging scaffolds."

Environmental considerations drive development of waste-minimized processes for this compound. Recent advancements include continuous flow synthesis reducing solvent consumption by 60% compared to batch methods. Such progress addresses sustainability-focused queries like "green synthesis of nitroheterocycles" while maintaining the compound's reaction yield (>85% in optimized conditions).

Market analyses indicate steady demand growth for 2604-39-9, particularly from Asia-Pacific pharmaceutical manufacturers. Regulatory compliance focuses on proper wastewater treatment for nitro-containing byproducts, a key concern for facilities searching "nitro compound biodegradation." Analytical method development remains active, with new UPLC techniques achieving detection limits of 0.1 ppm for environmental monitoring.

In conclusion, 2-chloro-5-nitro-pyridin-4-amine represents a critical building block bridging multiple scientific disciplines. Its evolving applications – from small molecule therapeutics to advanced materials – ensure continued relevance. Researchers and manufacturers seeking "high-purity nitropyridine suppliers" or "pyridine derivative reactivity" will find this compound indispensable for next-generation chemical innovations.

2604-39-9 (2-chloro-5-nitro-pyridin-4-amine) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:2604-39-9)2-chloro-5-nitro-pyridin-4-amine
A5176
Purity:99%/99%
Quantity:100g/25g
Price ($):1231.0/330.0
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