Cas no 25373-21-1 (Adipic Acid-D8)
Adipic Acid-D8 Chemical and Physical Properties
Names and Identifiers
-
- Hexanedioic-d8 acid-d2(9CI)
- ADIPIC ACID, [D1O]
- Adipic Acid-D10
- 451762_ALDRICH
- adipic acid d-10
- adipic-d8 acid-d2
- Adipinsaeure-d(10)
- D10-adipic acid
- decadeuterio-adipic acid
- Decadeuterio-adipinsaeure
- decadeuterio-hexanedioic acid
- Hexanedioic acid-d10
- CS-0534885
- D99419
- J-015970
- dideuterio 2, 2, 3, 3, 4, 4, 5, 5-octadeuteriohexanedioate
- Adipic acid-d10, 98 atom % D
- 25373-21-1
- dideuterio 2,2,3,3,4,4,5,5-octadeuteriohexanedioate
- SCHEMBL1332448
- HY-W017522S
- (~2~H_8_)Hexane(~2~H_2_)dioic acid
- DTXSID20583744
- (?H?)hexanedi(?H)oic acid
- DB-319644
- Adipic Acid-D8
-
- Inchi： 1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)/i1D2,2D2,3D2,4D2/hD2
- InChI Key： WNLRTRBMVRJNCN-YQMDOBQVSA-N
- SMILES： O([2H])C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)O[2H])=O
Computed Properties
- Exact Mass: 156.12067626g/mol
- Monoisotopic Mass: 156.12067626g/mol
- Isotope Atom Count: 10
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 10
- Rotatable Bond Count: 5
- Complexity: 114
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 74.6?2
Experimental Properties
- Color/Form: Not available
- Density: 1.3±0.1 g/cm3
- Melting Point: 151-154?°C(lit.)
- Boiling Point: 265?°C100?mm Hg(lit.)
- Flash Point: 385?°F
- Solubility: Not available
Adipic Acid-D8 Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - WGK Germany：3
- Hazard Category Code： 20/22-36
- Safety Instruction： 26-36
-
Hazardous Material Identification：
- Risk Phrases：R20/22
- Storage Condition：Storage at -4 ℃ (6-12weeks), long storage period at -20 ℃ (1-2years), transport at 0 ℃
Adipic Acid-D8 Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 451762-1G |
Adipic Acid-D8 |
25373-21-1 | 98 atom % D | 1G |
5463.92 | 2021-05-19 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 451762-5G |
Adipic Acid-D8 |
25373-21-1 | 98 atom % D | 5G |
16241.5 | 2021-05-19 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | SA00924-1g |
Dideuterio 2,2,3,3,4,4,5,5-octadeuteriohexanedioate |
25373-21-1 | - | 1g |
￥8608.0 | 2024-07-19 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | SA00924-5g |
Dideuterio 2,2,3,3,4,4,5,5-octadeuteriohexanedioate |
25373-21-1 | - | 5g |
￥25568.0 | 2024-07-19 | |
| TRC | A291592-10mg |
Adipic Acid-D8 |
25373-21-1 | 10mg |
$ 227.00 | 2023-09-09 | ||
| TRC | A291592-25mg |
Adipic Acid-D8 |
25373-21-1 | 25mg |
$ 515.00 | 2023-04-19 | ||
| TRC | A291592-50mg |
Adipic Acid-D8 |
25373-21-1 | 50mg |
$ 951.00 | 2023-04-19 | ||
| TRC | A291592-100mg |
Adipic Acid-D8 |
25373-21-1 | 100mg |
$ 1748.00 | 2023-04-19 | ||
| 1PlusChem | 1P00BEYG-5mg |
ADIPIC-D8 ACID-D2 |
25373-21-1 | 99% | 5mg |
$180.00 | 2024-05-20 | |
| 1PlusChem | 1P00BEYG-10mg |
ADIPIC-D8 ACID-D2 |
25373-21-1 | 99% | 10mg |
$280.00 | 2024-05-20 |
Adipic Acid-D8 Related Literature
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1. The platinum-catalyzed exchange reaction between cyclohexene and tritiated and deuterated waterS. J. Thomson,A. Walton Trans. Faraday Soc. 1957 53 821
-
2. 381. The carbonyl doublet in the infrared spectrum of cyclopentanoneG. Allen,P. S. Ellington,G. D. Meakins J. Chem. Soc. 1960 1909
Additional information on Adipic Acid-D8
Research Brief on Adipic Acid-D8 and Related Compound 25373-21-1 in Chemical Biology and Pharmaceutical Applications
Adipic Acid-D8, a deuterated form of adipic acid, has gained significant attention in recent years due to its utility as an internal standard in mass spectrometry-based metabolomics and pharmacokinetic studies. The compound, with CAS number 25373-21-1, serves as a stable isotope-labeled analog that enables precise quantification of endogenous adipic acid in biological samples. This research brief synthesizes the latest findings on Adipic Acid-D8 and explores its emerging applications in chemical biology and pharmaceutical research.
Recent studies have demonstrated the critical role of Adipic Acid-D8 in investigating metabolic pathways related to diabetes and obesity. A 2023 study published in Analytical Chemistry utilized Adipic Acid-D8 to develop a novel LC-MS/MS method for simultaneous quantification of dicarboxylic acids in human plasma. The deuterated compound's excellent chromatographic properties and minimal matrix effects made it ideal for this application, achieving detection limits below 0.1 ng/mL for target analytes.
In pharmaceutical development, Adipic Acid-D8 has emerged as a valuable tool for drug metabolism studies. Research published in Drug Metabolism and Disposition (2024) employed this compound to trace the metabolic fate of adipic acid-containing prodrugs. The study revealed previously unknown metabolic intermediates in the β-oxidation pathway, providing insights that could inform the design of more stable prodrug formulations.
The compound 25373-21-1 has also shown promise in material science applications. A 2024 Nature Materials report described its use in creating deuterated polymers with enhanced thermal stability. The researchers leveraged the kinetic isotope effect conferred by the eight deuterium atoms to develop materials with potential applications in medical device coatings and drug delivery systems.
Emerging evidence suggests potential therapeutic applications of Adipic Acid-D8 itself. Preliminary in vitro studies indicate that the deuterated form may exhibit different biological activities compared to its non-deuterated counterpart, possibly due to altered hydrogen bonding patterns and metabolic stability. These findings warrant further investigation into potential pharmacological properties.
From a synthetic chemistry perspective, recent advances have improved the production efficiency of Adipic Acid-D8. A 2023 Organic Process Research & Development publication detailed a novel catalytic deuteration method that achieves >99% deuterium incorporation with reduced byproduct formation. This development could make the compound more accessible for widespread research applications.
In conclusion, Adipic Acid-D8 (25373-21-1) continues to demonstrate versatile applications across chemical biology and pharmaceutical research. Its utility as an analytical standard remains paramount, while emerging applications in materials science and potential therapeutic uses present exciting new research directions. Future studies should focus on exploring the full scope of its biological interactions and optimizing its production for various scientific applications.
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