• 1. Surfactant-mediated thioglycosylation of 1-hydroxy sugars in water
  Trichada Ratthachag,Supanat Buntasana,Tirayut Vilaivan,Panuwat Padungros Org. Biomol. Chem. 2021 19 822
• 2. Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans
  Nisha Varghese,Sijie Yang,Preeti Sejwal,Yan-Yeung Luk Chem. Commun. 2013 49 10418
• 3. Disorder–order phase change of ω-(N-pyrrolyl)alkanethiol self-assembled monolayers on gold induced by STM scans and thermal activation
  Joon Sung Lee,Young Shik Chi,Jinhee Kim,Wan Soo Yun,Insung S. Choi Phys. Chem. Chem. Phys. 2008 10 3138
• 4. On the self assembly of short chain alkanedithiols
  Hicham Hamoudi,Zhiang Guo,Mirko Prato,Céline Dablemont,Wan Quan Zheng,Bernard Bourguignon,Maurizio Canepa,Vladimir A. Esaulov Phys. Chem. Chem. Phys. 2008 10 6836
• 5. Overcoming metal-induced fluorescence quenching on plasmo-photonic metasurfaces coated by a self-assembled monolayer
  Bongseok Choi,Masanobu Iwanaga,Hideki T. Miyazaki,Yoshimasa Sugimoto,Akihiro Ohtake,Kazuaki Sakoda Chem. Commun. 2015 51 11470

• Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Thiols Alkylthiols
• Other Chemical additives Functional Additives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical additives

1-Pentadecanethiol (CAS No. 25276-70-4): A Comprehensive Overview

1-Pentadecanethiol, also known by its CAS registry number 25276-70-4, is a sulfur-containing organic compound that has garnered significant attention in various scientific and industrial applications. This compound, classified as a thiol, belongs to the broader category of sulfur-containing organic compounds and exhibits unique chemical properties due to its structure. The molecule consists of a pentadecyl chain (a straight-chain alkyl group with 15 carbon atoms) attached to a thiol (-SH) functional group. This combination makes 1-pentadecanethiol a versatile compound with potential applications in materials science, surface chemistry, and biotechnology.

The chemical formula of 1-pentadecanethiol is C??H??SH, and its molecular weight is approximately 238.43 g/mol. The compound is characterized by its long hydrocarbon chain, which imparts hydrophobic properties, and the thiol group, which confers reactivity and the ability to form strong bonds with various surfaces. Recent studies have highlighted the importance of understanding the interplay between the hydrophobic tail and the reactive thiol head in determining the compound's behavior in different environments.

One of the most notable applications of 1-pentadecanethiol is in the formation of self-assembled monolayers (SAMs) on gold surfaces. SAMs are ultra-thin layers of molecules that adsorb onto a substrate in an orderly fashion, driven by intermolecular forces such as van der Waals interactions. The ability of 1-pentadecanethiol to form SAMs has been extensively studied for its potential in nanotechnology, biosensors, and electronic devices. Recent research has explored how the length of the alkyl chain affects the packing density and stability of these monolayers, providing insights into optimizing their performance for specific applications.

In addition to SAMs, 1-pentadecanethiol has been investigated for its role in surface modification and wetting properties. The compound's long hydrocarbon chain contributes to its amphiphilic nature, allowing it to interact with both polar and non-polar surfaces. This property has been leveraged in creating water-repellent surfaces and in studying interfacial phenomena at the nanoscale. Recent advancements in surface science have utilized 1-pentadecanethiol to explore the dynamics of molecular self-assembly under varying environmental conditions, such as temperature and humidity.

The synthesis of 1-pentadecanethiol typically involves the reaction of pentadecanol with sulfur dioxide or other sulfur-containing reagents under controlled conditions. However, recent studies have focused on developing more efficient and environmentally friendly synthesis methods. For instance, researchers have explored catalytic processes that minimize waste generation while maintaining high yields of the desired product.

Another emerging area of interest is the use of 1-pentadecanethiol in biotechnology and medicine. The compound's ability to form stable monolayers on gold surfaces has made it a valuable tool in the development of biosensors for detecting biomolecules such as DNA, proteins, and enzymes. Recent breakthroughs have demonstrated how modifying the surface chemistry with 1-pentadecanethiol can enhance sensor sensitivity and selectivity, paving the way for more accurate diagnostic tools.

Furthermore, 1-pentadecanethiol has been studied for its potential in drug delivery systems. The compound's amphiphilic nature allows it to interact with both hydrophilic and hydrophobic components, making it a candidate for constructing drug carriers that can target specific tissues or cells. Recent research has focused on incorporating 1-pentadecanethiol into lipid-based nanoparticles to improve drug encapsulation efficiency and controlled release profiles.

In terms of environmental applications, 1-pentadecanethiol has been investigated for its role in oil spill remediation. The compound's hydrophobic properties enable it to interact with hydrocarbons present in oil spills, potentially facilitating their removal from water surfaces. Recent studies have explored how combining 1-pentadecanethiol with other surfactants can enhance oil dispersion and degradation rates under simulated spill conditions.

Despite its numerous applications, there are challenges associated with using 1-pentadecanethiol on an industrial scale. One key issue is ensuring consistent quality control during synthesis to maintain product purity and functionality. Additionally, further research is needed to fully understand how environmental factors such as pH levels and ionic strength influence the behavior of 1-pentadecanethiol-based systems.

In conclusion, 1-pentadecanethiol (CAS No. 25276-70-4) is a multifaceted compound with promising applications across various fields due to its unique chemical properties. From forming self-assembled monolayers to advancing biosensor technology and drug delivery systems, this compound continues to be a subject of intense scientific investigation. As research progresses, we can expect even more innovative uses for this versatile sulfur-containing organic compound.

• 2079-95-0(1-Tetradecanethiol)
• 1455-21-6(1-Nonanethiol)
• 1191-62-4(1,8-Octanedithiol)
• 2885-00-9(Octadecanethiol)
• 2917-26-2(1-Hexadecanethiol)
• 928-98-3(1,5-Pentanedithiol)
• 1191-67-9(1,10-Decanedithiol)
• 143-10-2(1-decanethiol)
• 1191-43-1(1,6-Hexanedithiol)
• 1639-09-4(1-Heptanethiol)