• 1. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 5. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792

Acetylthiocholine Bromide (CAS No. 25025-59-6): A Comprehensive Overview

Acetylthiocholine bromide, with the chemical formula C₅H₁₀BrNO₂S, is a significant compound in the field of biochemistry and pharmacology. Its CAS number, CAS No. 25025-59-6, uniquely identifies it in scientific literature and databases. This compound has garnered attention due to its versatile applications, particularly in neurological research and drug development.

The structure of Acetylthiocholine bromide consists of an acetyl group attached to a choline moiety, with a bromine substituent. This configuration makes it a valuable intermediate in synthesizing various bioactive molecules. The choline part of the molecule is particularly noteworthy, as it is a precursor to acetylcholine, a crucial neurotransmitter involved in memory, muscle control, and other essential functions.

In recent years, Acetylthiocholine bromide has been extensively studied for its potential role in modulating cholinergic systems. Research has shown that it can serve as a prodrug for acetylcholine, enhancing its availability and duration of action in the synaptic cleft. This property makes it particularly relevant in the development of treatments for cognitive disorders such as Alzheimer's disease and Parkinson's disease.

One of the most compelling aspects of Acetylthiocholine bromide is its ability to cross the blood-brain barrier (BBB). This characteristic is critical for developing therapeutic agents that need to exert their effects directly within the central nervous system. Studies have demonstrated that when administered peripherally, Acetylthiocholine bromide can be efficiently transported into the brain, where it is metabolized into acetylcholine.

The pharmacological profile of Acetylthiocholine bromide has also been explored in terms of its interactions with muscarinic and nicotinic receptors. These receptors are integral to the cholinergic system and play a vital role in various physiological processes. Preclinical studies have indicated that Acetylthiocholine bromide can selectively activate certain subtypes of these receptors, offering potential benefits in treating conditions like myasthenia gravis and schizophrenia.

Beyond its neurological applications, Acetylthiocholine bromide has shown promise in other areas of medical research. For instance, it has been investigated for its potential role in enhancing cognitive function in elderly individuals with mild cognitive impairment (MCI). The compound's ability to boost acetylcholine levels may help improve memory and attention span, making it a promising candidate for non-pharmacological interventions.

The synthesis of Acetylthiocholine bromide involves well-established chemical methodologies, making it accessible for industrial-scale production. The process typically involves the reaction of acetic anhydride with thiocholine hydrobromide, followed by purification steps to obtain high-purity material. This synthetic route ensures that researchers and pharmaceutical companies can obtain consistent quality material for their studies and formulations.

In terms of safety and handling, Acetylthiocholine bromide is generally considered to be well-tolerated when used under controlled conditions. However, like many biochemical compounds, it should be handled with appropriate personal protective equipment (PPE) to minimize exposure risks. Proper storage conditions are also essential to maintain its stability and efficacy.

The regulatory landscape for compounds like Acetylthiocholine bromide is continually evolving. Regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) provide guidelines for the safe use and testing of such substances in clinical trials. Compliance with these regulations ensures that new therapies based on compounds like this are developed responsibly and effectively.

The future prospects for Acetylthiocholine bromide are bright, with ongoing research exploring new applications and formulations. Advances in drug delivery systems may further enhance its therapeutic potential by improving bioavailability and targeting specificity. Additionally, interdisciplinary approaches combining chemistry, pharmacology, and neuroscience are likely to yield innovative uses for this versatile compound.

In conclusion, Acetylthiocholine bromide, identified by its CAS number CAS No. 25025-59-6, is a multifaceted compound with significant implications in medical research and drug development. Its unique structural properties make it an effective prodrug for acetylcholine and a valuable tool for studying cholinergic systems. As research continues to uncover new applications and refine synthetic methods, the therapeutic potential of this compound is poised to expand further.

• 66-23-9(Acetylcholine bromide)
• 333-31-3(Acetyl-β-methylcholine Bromide)
• 24943-60-0(Benzoylcholine Bromide)
• 17518-43-3(Benzoylcholine iodide)
• 2260-50-6(Acetylcholine iodide)
• 60-31-1(Acetylcholine chloride)
• 927-86-6(Acetylcholine perchlorate)
• 1866-15-5(Acetylthiocholine iodide)
• 1866-16-6(Butyrylthiocholine iodide)
• 2964-09-2(2-Benzoyloxyethyl(trimethyl)azanium Chloride)