Cas no 249921-19-5 (Anamorelin)
Anamorelin is a selective ghrelin receptor agonist designed to address cachexia and muscle wasting, particularly in cancer patients. It mimics the action of ghrelin, stimulating appetite and promoting muscle protein synthesis. Clinically, Anamorelin has demonstrated efficacy in increasing lean body mass and body weight while improving nutritional parameters. Its mechanism targets the ghrelin pathway without directly influencing tumor growth, offering a focused therapeutic approach. The compound exhibits oral bioavailability and a favorable pharmacokinetic profile, making it suitable for chronic administration. Research highlights its potential in mitigating cancer-related cachexia, where maintaining muscle mass and weight is critical for patient outcomes. Further studies continue to explore its broader applications in metabolic disorders.
Anamorelin structure
Product Name:Anamorelin
CAS No:249921-19-5
MF:C31H42N6O3
MW:546.70359
MDL:MFCD11973671
CID:67214
PubChem ID:9828911
Update Time:2025-05-27
Anamorelin Chemical and Physical Properties
Names and Identifiers
-
- Anamorelin
- (3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
- 3-Piperidinecarboxylic acid, 1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-, trimethylhydrazide, (3R)-
- Rc 1291
- Unii-dd5rba1nkf
- ONO-7643
- Anamorelin (RC-1291)
- (R)-1-((S)-2-((1H-indol-3-yl)methyl)-5-amino-5-methyl-4-oxohexanoyl)-3-benzyl-N,N',N'-trimethylpiperidine-3-carbohydrazide
- 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
- DD5RBA1NKF
- ONO7643
- RC-1291
- 3-piperidinecarboxylic acid, 1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-, 1,2,2-trimethylhydrazide, (3R)-
- BRD-K01174345-001-01-9
- (3R)-1-((2R)-2-((2-AMINO-2-METHYLPROPANOYL)AMINO)-3-(INDOL-3-YL)PROPANOYL)-3-BENZYL-N,N',N'-TRIMETHYLPIPERIDINE-3-CARBOHYDRAZIDE
- 2-amino-N-((2R)-1-((3R)-3-benzyl-3-(N,N',N'-trimethylhydrazinecarbonyl)piperidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropanamide
- AC-33703
- MFCD11973671
- NS00072505
- CCG-269985
- EX-A154
- Anamorelin [INN]
- BCP06108
- s4980
- Q20707542
- ANAMORELIN [MI]
- HY-14734
- anamoreline
- RC-1291;ONO-7643
- DTXSID20179702
- AS-75284
- ONO-7643;Anamorelin
- NCGC00378854-01
- 2-AMINO-N-[(2R)-1-[(3R)-3-BENZYL-3-(N,N',N'-TRIMETHYLHYDRAZINECARBONYL)PIPERIDIN-1-YL]-3-(1H-INDOL-3-YL)-1-OXOPROPAN-2-YL]-2-METHYLPROPANAMIDE
- CHEMBL2110579
- ST-1291
- AKOS030526752
- DB06645
- anamorelina
- SCHEMBL935751
- 249921-19-5
- anamorelinum
- ANAMORELIN [WHO-DD]
- DTXCID40102193
-
- MDL： MFCD11973671
- Inchi： 1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1
- InChI Key： VQPFSIRUEPQQPP-MXBOTTGLSA-N
- SMILES： [H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O
Computed Properties
- Exact Mass: 546.33200
- Monoisotopic Mass: 546.33183922g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 9
- Heavy Atom Count: 40
- Rotatable Bond Count: 12
- Complexity: 904
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.8
- Topological Polar Surface Area: 115?2
Experimental Properties
- Density: 1.214
- PSA: 114.77000
- LogP: 3.74810
Anamorelin Security Information
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Anamorelin Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| DC Chemicals | DC7357-100 mg |
Anamorelin |
249921-19-5 | >98% | 100mg |
$350.0 | 2022-03-01 | |
| DC Chemicals | DC7357-250 mg |
Anamorelin |
249921-19-5 | >98% | 250mg |
$700.0 | 2022-03-01 | |
| DC Chemicals | DC7357-1 g |
Anamorelin |
249921-19-5 | >98% | 1g |
$1400.0 | 2022-03-01 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A125440-50mg |
Anamorelin |
249921-19-5 | ≥98% | 50mg |
￥3810.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A125440-5mg |
Anamorelin |
249921-19-5 | ≥98% | 5mg |
￥667.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A125440-10mg |
Anamorelin |
249921-19-5 | ≥98% | 10mg |
￥1132.90 | 2023-09-04 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | L-DP727-5mg |
Anamorelin |
249921-19-5 | ≥98% | 5mg |
￥744.0 | 2022-09-28 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | L-DP727-25mg |
Anamorelin |
249921-19-5 | ≥98% | 25mg |
￥3130.0 | 2022-09-28 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | L-DP727-1mg |
Anamorelin |
249921-19-5 | ≥98% | 1mg |
￥277.0 | 2022-09-28 | |
| MedChemExpress | HY-14734-10mM*1mLinDMSO |
Anamorelin |
249921-19-5 | 99.86% | 10mM*1mLinDMSO |
￥1203 | 2022-05-30 |
Anamorelin Related Literature
-
Wei Chang,Genye He,Kuan Yan,Zhanliang Wang,Yufeng Zhang,Tianyu Dong,Yunxi Liu,Lisi Zhang,Liu Hong Anal. Methods 2021 13 5838
Related Categories
- Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Peptides
- Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Peptides
- Pharmaceutical and Biochemical Products Medical Disease Classifications
- Other Chemical Reagents
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