Cas no 24821-17-8 (2-Nitro-6-(trifluoromethyl)aniline)

2-Nitro-6-(trifluoromethyl)aniline is a fluorinated aromatic compound featuring both nitro and trifluoromethyl functional groups on an aniline backbone. This structure imparts unique electronic and steric properties, making it valuable as an intermediate in organic synthesis, particularly for pharmaceuticals, agrochemicals, and specialty materials. The presence of the electron-withdrawing nitro and trifluoromethyl groups enhances reactivity in electrophilic and nucleophilic substitution reactions. Its high purity and stability under controlled conditions ensure consistent performance in synthetic applications. The compound is typically handled under inert conditions due to its sensitivity to moisture and light. Proper storage and handling protocols are recommended to maintain its integrity for research and industrial use.

2-Nitro-6-(trifluoromethyl)aniline structure

24821-17-8 structure

Product Name:2-Nitro-6-(trifluoromethyl)aniline

CAS No:24821-17-8

MF:C₇H₅F₃N₂O₂

MW:206.122011899948

MDL:MFCD08532494

CID:240985

PubChem ID:10703457

Update Time:2025-05-24

2-Nitro-6-(trifluoromethyl)aniline Chemical and Physical Properties

Names and Identifiers

- 2-Nitro-6-(trifluoromethyl)aniline
- 2-AMINO-3-NITROBENZOTRIFLUORIDE
- Benzenamine,2-nitro-6-(trifluoromethyl)-
- 2-Nitro-6-trifluormethyl-anilin
- 2-nitro-6-trifluoromethylaniline
- 2-nitro-6-trifluoromethyl-phenylamine
- 6-nitro-2-trifluoromethylaniline
- SB78572
- PS-10534
- 2-Amino-3-nitrobenzotrifluoride 99%
- DTXSID50443726
- Benzenamine, 2-nitro-6-(trifluoromethyl)-
- SCHEMBL1768922
- CL8407
- 2-Nitro-6-(trifluoromethyl)aniline, 97%
- MFCD08532494
- 2-nitro-6-trifluoromethyl aniline
- AKOS015999907
- J-015687
- 24821-17-8
- EN300-127182
- AKOS015912862
- DB-365204
- 2-amino-3-trifluoromethylnitrobenzene
- MDL： MFCD08532494
- Inchi： 1S/C7H5F3N2O2/c8-7(9,10)4-2-1-3-5(6(4)11)12(13)14/h1-3H,11H2
- InChI Key： MFLJFFUIURSSKM-UHFFFAOYSA-N
- SMILES： FC(C1C=CC=C(C=1N)[N+](=O)[O-])(F)F

Computed Properties

Exact Mass: 206.03000
Monoisotopic Mass: 206.03031189g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Heavy Atom Count: 14
Rotatable Bond Count: 2
Complexity: 226
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 2.5
Topological Polar Surface Area: 71.8?2

Experimental Properties

Color/Form: No data available
Density: 1.503±0.06 g/cm3 (20 oC 760 Torr),
Melting Point: 48-52?°C
Boiling Point: 261.1±35.0 oC (760 Torr),
Flash Point: Degrees Fahrenheit:>230°F
Degrees Celsius:>110°C
Refractive Index: 1.525
Solubility: Very slightly soluble (0.17 g/l) (25 o C),
PSA: 71.84000
LogP: 3.30020

2-Nitro-6-(trifluoromethyl)aniline Security Information

Signal Word：warning
Hazard Statement： Harmful
Warning Statement： P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
Storage Condition：Store at 4°C,-4At ℃Store…Better

2-Nitro-6-(trifluoromethyl)aniline Customs Data

HS CODE：2921420090
Customs Data：

China Customs Code:
2921420090

Overview:

2921420090 Other aniline derivatives and their salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to

Summary:

HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2-Nitro-6-(trifluoromethyl)aniline Pricemore >>

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SHANG HAI XIAN DING Biotechnology Co., Ltd.	L-HJ181-1g	2-Nitro-6-(trifluoromethyl)aniline	24821-17-8	97%	1g	￥1221.0	2022-09-28
SHANG HAI XIAN DING Biotechnology Co., Ltd.	L-HJ181-200mg	2-Nitro-6-(trifluoromethyl)aniline	24821-17-8	97%	200mg	￥400.0	2022-09-28
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Alichem	A013006395-250mg	2-Nitro-6-(trifluoromethyl)aniline	24821-17-8	97%	250mg	$489.60	2023-09-02
Alichem	A013006395-500mg	2-Nitro-6-(trifluoromethyl)aniline	24821-17-8	97%	500mg	$831.30	2023-09-02
Alichem	A013006395-1g	2-Nitro-6-(trifluoromethyl)aniline	24821-17-8	97%	1g	$1519.80	2023-09-02
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2-Nitro-6-(trifluoromethyl)aniline Suppliers

Amadis Chemical Company Limited

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Audited Supplier

(CAS:24821-17-8)2-Nitro-6-(trifluoromethyl)aniline

Order Number:A877792

Stock Status:in Stock

Quantity:5g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 09:55

Price ($):231.0

Email:[email protected]

Product Official Link

2-Nitro-6-(trifluoromethyl)aniline Related Literature

1. A convenient copper-catalyzed direct amination of nitroarenes with O-alkylhydroxylamines

Shinzo Seko,Kunihito Miyake,Norio Kawamura J. Chem. Soc. Perkin Trans. 1 1999 1437

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Additional information on 2-Nitro-6-(trifluoromethyl)aniline

Introduction to 2-Nitro-6-(trifluoromethyl)aniline (CAS No. 24821-17-8)

2-Nitro-6-(trifluoromethyl)aniline, with the CAS number 24821-17-8, is a versatile compound that has garnered significant attention in the fields of organic chemistry, pharmaceuticals, and materials science. This aromatic amine features a nitro group and a trifluoromethyl group, which endow it with unique chemical properties and reactivity. This introduction will delve into the chemical structure, synthesis methods, applications, and recent research advancements related to this compound.

The molecular formula of 2-Nitro-6-(trifluoromethyl)aniline is C₉H₆F₃N₂O₂, and its molecular weight is approximately 213.15 g/mol. The presence of the nitro group (NO₂) and the trifluoromethyl group (CF₃) imparts strong electron-withdrawing properties to the molecule, making it highly reactive in various chemical reactions. The aromatic ring provides additional stability and reactivity, making this compound a valuable intermediate in the synthesis of more complex molecules.

The synthesis of 2-Nitro-6-(trifluoromethyl)aniline can be achieved through several methods. One common approach involves the nitration of 6-(trifluoromethyl)aniline using a mixture of nitric acid and sulfuric acid. This method is well-documented in the literature and has been optimized to achieve high yields and purity. Another method involves the reaction of 3-nitrobenzotrifluoride with ammonia in the presence of a suitable catalyst, such as palladium on carbon. This approach offers an alternative route that can be tailored to specific process requirements.

In the pharmaceutical industry, 2-Nitro-6-(trifluoromethyl)aniline has found applications as an intermediate in the synthesis of various drugs. Its unique chemical properties make it suitable for use in the development of compounds with specific biological activities. For example, recent studies have explored its potential in the synthesis of anti-cancer agents and anti-inflammatory drugs. The trifluoromethyl group enhances lipophilicity, which can improve drug absorption and distribution in biological systems.

Beyond pharmaceuticals, 2-Nitro-6-(trifluoromethyl)aniline has also been investigated for its use in materials science. Its strong electron-withdrawing properties make it a valuable component in the development of electronic materials, such as organic semiconductors and dyes for photovoltaic applications. Research in this area has shown that compounds derived from 2-Nitro-6-(trifluoromethyl)aniline can exhibit improved charge transport properties and stability under various environmental conditions.

The environmental impact of chemicals is an important consideration in their development and application. Studies on the environmental fate and toxicity of 2-Nitro-6-(trifluoromethyl)aniline have shown that it degrades relatively quickly under natural conditions, reducing its potential for long-term environmental accumulation. However, proper handling and disposal practices are still essential to minimize any adverse effects on ecosystems.

In conclusion, 2-Nitro-6-(trifluoromethyl)aniline (CAS No. 24821-17-8) is a multifaceted compound with significant potential in various scientific and industrial applications. Its unique chemical structure and properties make it a valuable intermediate in pharmaceutical synthesis, materials science, and other fields. Ongoing research continues to uncover new uses and improvements for this compound, highlighting its importance in modern chemistry.

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