Cas no 247254-47-3 (Benzenemethanamine,3-bromo-4-methoxy-)

3-Bromo-4-methoxybenzenemethanamine is a brominated and methoxylated aromatic amine with potential applications as an intermediate in organic synthesis and pharmaceutical development. The compound’s structure, featuring both electron-donating (methoxy) and electron-withdrawing (bromo) substituents on the benzene ring, offers versatility in further functionalization, enabling its use in cross-coupling reactions, nucleophilic substitutions, or as a precursor for bioactive molecules. The methoxy group enhances solubility in organic solvents, facilitating purification and handling, while the bromine atom provides a reactive site for metal-catalyzed transformations. This compound is particularly valuable in medicinal chemistry for the design of targeted ligands or pharmacophores due to its balanced electronic properties and synthetic flexibility.
Benzenemethanamine,3-bromo-4-methoxy- structure
247254-47-3 structure
Product Name:Benzenemethanamine,3-bromo-4-methoxy-
CAS No:247254-47-3
MF:C8H10BrNO
MW:216.07510137558
MDL:MFCD03410965
CID:246127
PubChem ID:22026276
Update Time:2025-10-30

Benzenemethanamine,3-bromo-4-methoxy- Chemical and Physical Properties

Names and Identifiers

    • Benzenemethanamine,3-bromo-4-methoxy-
    • (3-bromo-4-methoxyphenyl)methanamine
    • 3-bromo-4-methoxyBenzenemethanamine
    • 3-Bromo-4-methoxybenzylamine
    • {[3-bromo-4-(methyloxy)phenyl]methyl}amine
    • 1-[3-bromo-4-(methyloxy)phenyl]methanamine
    • Benzenemethanamine,3-bromo-4-methoxy
    • [[3-Bromo-4-(methyloxy)phenyl]methyl]amine
    • A857117
    • CS-0216902
    • Z446020722
    • EN300-64612
    • 2-Bromo-4-aminomethylanisole
    • Benzenemethanamine, 3-bromo-4-methoxy-
    • MFCD03410965
    • 3-Bromo-4-methoxy-benzenemethanamine
    • SB23002
    • A1-00697
    • 1-(3-Bromo-4-methoxyphenyl)methanamine
    • 247254-47-3
    • {[3-bromo-4-(methyloxy)phenyl]-methyl}amine
    • PZYWNKFZCOGPJX-UHFFFAOYSA-N
    • AC5724
    • AKOS008139526
    • SCHEMBL1364967
    • DTXSID00621719
    • Not available;3-Bromo-4-methoxybenzylamine
    • FT-0719380
    • SY028629
    • DA-24010
    • MDL： MFCD03410965
    • Inchi： 1S/C8H10BrNO/c1-11-8-3-2-6(5-10)4-7(8)9/h2-4H,5,10H2,1H3
    • InChI Key： PZYWNKFZCOGPJX-UHFFFAOYSA-N
    • SMILES： BrC1=C(C=CC(=C1)CN)OC

Computed Properties

  • Exact Mass: 214.99500
  • Monoisotopic Mass: 214.995
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 121
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 35.2A^2
  • XLogP3: 1.4

Experimental Properties

  • Density: 1.444±0.06 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 290.2±25.0 oC (760 Torr),
  • Flash Point: 129.3±23.2 oC,
  • Refractive Index: 1.57
  • Solubility: Slightly soluble (4.3 g/l) (25 o C),
  • PSA: 35.25000
  • LogP: 2.61670

Benzenemethanamine,3-bromo-4-methoxy- Customs Data

  • HS CODE：2922299090
  • Customs Data：

    China Customs Code:

    2922299090

    Overview:

    2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Benzenemethanamine,3-bromo-4-methoxy- Pricemore >>

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Benzenemethanamine,3-bromo-4-methoxy- Production Method

Benzenemethanamine,3-bromo-4-methoxy- Related Literature

Additional information on Benzenemethanamine,3-bromo-4-methoxy-

Recent Advances in the Study of Benzenemethanamine,3-bromo-4-methoxy- (CAS: 247254-47-3) in Chemical Biology and Pharmaceutical Research

Benzenemethanamine,3-bromo-4-methoxy- (CAS: 247254-47-3) is a chemical compound that has garnered significant attention in recent years due to its potential applications in drug discovery and chemical biology. This compound, characterized by its bromo and methoxy functional groups, serves as a key intermediate in the synthesis of various pharmacologically active molecules. Recent studies have explored its utility in the development of novel therapeutic agents, particularly in the areas of oncology and neurology.

One of the most notable advancements in the study of Benzenemethanamine,3-bromo-4-methoxy- is its role in the synthesis of kinase inhibitors. Kinases are critical targets in cancer therapy, and the bromo-methoxy substitution pattern of this compound has been shown to enhance binding affinity and selectivity for specific kinase domains. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibited potent inhibitory activity against EGFR (Epidermal Growth Factor Receptor), a key driver in non-small cell lung cancer (NSCLC).

In addition to its applications in oncology, Benzenemethanamine,3-bromo-4-methoxy- has also been investigated for its potential in neurological disorders. Research published in ACS Chemical Neuroscience highlighted its use as a precursor in the synthesis of serotonin receptor modulators. These modulators have shown promise in treating conditions such as depression and anxiety, with improved pharmacokinetic profiles compared to existing therapeutics.

The synthetic pathways for Benzenemethanamine,3-bromo-4-methoxy- have also been optimized in recent years. A 2022 study in Organic Process Research & Development reported a scalable and cost-effective method for its production, utilizing palladium-catalyzed cross-coupling reactions. This advancement has significant implications for industrial-scale manufacturing, ensuring a stable supply for further research and development.

Despite these promising developments, challenges remain in the clinical translation of Benzenemethanamine,3-bromo-4-methoxy--based compounds. Issues such as metabolic stability and off-target effects need to be addressed through further structural optimization and in vivo studies. However, the compound's versatility and demonstrated biological activity make it a valuable scaffold for future drug discovery efforts.

In conclusion, Benzenemethanamine,3-bromo-4-methoxy- (CAS: 247254-47-3) represents a promising candidate in the field of chemical biology and pharmaceutical research. Its applications in kinase inhibition and neurological modulation, coupled with advances in synthetic methodologies, underscore its potential to contribute to the development of next-generation therapeutics. Ongoing research will be crucial in unlocking its full therapeutic potential and addressing existing limitations.

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