Cas no 246023-54-1 (4-methoxy-2,5-dimethylphenylboronic Acid)

4-Methoxy-2,5-dimethylphenylboronic acid is a boronic acid derivative featuring methoxy and dimethyl substituents on the aromatic ring. This compound is widely utilized as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of biaryl structures with high selectivity and efficiency. Its sterically hindered aromatic ring enhances stability and reactivity in palladium-catalyzed transformations. The electron-donating methoxy group further influences reactivity patterns, making it valuable in pharmaceutical and agrochemical synthesis. The compound is typically supplied as a white to off-white crystalline solid with good purity, ensuring consistent performance in demanding applications. Proper storage under inert conditions is recommended to maintain stability.
4-methoxy-2,5-dimethylphenylboronic Acid structure
246023-54-1 structure
Product Name:4-methoxy-2,5-dimethylphenylboronic Acid
CAS No:246023-54-1
MF:C9H13BO3
MW:180.008723020554
MDL:MFCD06801676
CID:252187
PubChem ID:5233015
Update Time:2025-06-13

4-methoxy-2,5-dimethylphenylboronic Acid Chemical and Physical Properties

Names and Identifiers

    • 2,5-Dimethyl-4-methoxyphenylboronic acid
    • 4-Methoxy-2,5-dimethylphenylboronic Acid (contains varying amounts of Anhydride)
    • (4-methoxy-2,5-dimethylphenyl)boronic acid
    • 4-Methoxy-2,5-dimethylphenylboronic acid
    • Boronic acid,(4-methoxy-2,5-dimethylphenyl)- (9CI)
    • 4-Borono-2,5-dimethylanisole
    • 4-Methoxy-2,5-dimethylbenzeneboronic Acid (contains varying amounts of Anhydride)
    • 2,5-DIMETHYL-4-METHOXYBENZENEBORONIC ACID
    • Boronic acid, B-(4-methoxy-2,5-dimethylphenyl)-
    • IUUWNGBWUJVQCF-UHFFFAOYSA-N
    • SBB071161
    • AB300
    • 2,5-dimethyl-4-methoxy-phenylboronic acid
    • 2,5-Dimethyl-4-methoxyphenylboronicacid
    • A877863
    • DTXSID30411923
    • FT-0678845
    • (4-methoxy-2, 5-dimethylphenyl)boronic acid
    • 4-Methoxy-2,5-dimethylbenzeneboronic Acid
    • M2838
    • EN300-128260
    • SCHEMBL5859114
    • AKOS004119263
    • MFCD06801676
    • N12131
    • Z1201623917
    • Boronic acid, (4-methoxy-2,5-dimethylphenyl)-
    • AB30054
    • 246023-54-1
    • PS-9490
    • CS-0067911
    • 4-Methoxy-2,5-dimethylphenylboronic acid(contains varying amounts of Anhydride)
    • DB-010325
    • 4-methoxy-2,5-dimethylphenylboronic Acid
    • MDL： MFCD06801676
    • Inchi： 1S/C9H13BO3/c1-6-5-9(13-3)7(2)4-8(6)10(11)12/h4-5,11-12H,1-3H3
    • InChI Key： IUUWNGBWUJVQCF-UHFFFAOYSA-N
    • SMILES： O(C)C1=CC(C)=C(B(O)O)C=C1C

Computed Properties

  • Exact Mass: 180.09600
  • Monoisotopic Mass: 180.0957744g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 2
  • Complexity: 163
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 49.7

Experimental Properties

  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 340.0±52.0 °C at 760 mmHg
  • Flash Point: 159.4±30.7 °C
  • Refractive Index: 1.517
  • PSA: 49.69000
  • LogP: -0.00820
  • Vapor Pressure: 0.0±0.8 mmHg at 25°C

4-methoxy-2,5-dimethylphenylboronic Acid Security Information

4-methoxy-2,5-dimethylphenylboronic Acid Customs Data

  • HS CODE：2931900090
  • Customs Data：

    China Customs Code:

    2931900090

    Overview:

    2931900090. Other organic-Inorganic compound. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods). MFN tariff:6.5%. general tariff:30.0%

    Summary:

    2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

4-methoxy-2,5-dimethylphenylboronic Acid Pricemore >>

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4-methoxy-2,5-dimethylphenylboronic Acid Related Literature

Related Categories

Additional information on 4-methoxy-2,5-dimethylphenylboronic Acid

Comprehensive Overview of 4-Methoxy-2,5-dimethylphenylboronic Acid (CAS No. 246023-54-1): Properties, Applications, and Industry Insights

4-Methoxy-2,5-dimethylphenylboronic Acid (CAS No. 246023-54-1) is a specialized boronic acid derivative widely recognized for its role in organic synthesis and pharmaceutical intermediates. This compound belongs to the arylboronic acid family, characterized by its unique methoxy and dimethyl substitutions, which enhance its reactivity in Suzuki-Miyaura cross-coupling reactions. With the growing demand for high-purity reagents in drug discovery and material science, this chemical has garnered significant attention from researchers and manufacturers alike.

The molecular structure of 4-Methoxy-2,5-dimethylphenylboronic Acid (CAS No. 246023-54-1) features a boron-containing aromatic ring, making it a versatile building block for bioconjugation and catalysis. Its stability under ambient conditions and solubility in common organic solvents like THF and DMSO further elevate its utility in medicinal chemistry. Recent studies highlight its potential in designing targeted therapies, particularly in cancer research, where boronic acids are explored for their proteasome inhibition properties.

In the context of green chemistry, 4-Methoxy-2,5-dimethylphenylboronic Acid aligns with the industry's shift toward sustainable synthesis. Researchers are optimizing its use in metal-free reactions and flow chemistry systems to reduce waste. This trend resonates with search queries like "eco-friendly boronic acid applications" and "scalable Suzuki coupling reagents," reflecting user interest in environmentally benign alternatives.

From a commercial perspective, the compound's CAS No. 246023-54-1 serves as a critical identifier for procurement databases. Suppliers emphasize its ≥98% purity grades to meet the stringent requirements of GMP-compliant production. Analytical techniques such as HPLC and NMR are routinely employed to verify its quality, addressing common customer concerns about batch-to-batch consistency.

Emerging discussions in academic forums and patent filings reveal innovative applications of 4-Methoxy-2,5-dimethylphenylboronic Acid, including its integration into OLED materials and sensor technologies. These developments respond to trending searches like "boronic acids in optoelectronics" and "advanced functional materials." As the compound gains traction, its structure-activity relationships (SAR) are being meticulously mapped to unlock new drug candidates.

To ensure safe handling, technical datasheets for CAS No. 246023-54-1 recommend standard laboratory precautions, including the use of nitrile gloves and ventilation. While not classified as hazardous, its moisture-sensitive nature necessitates storage under argon or nitrogen atmospheres—a detail frequently queried by end-users.

In summary, 4-Methoxy-2,5-dimethylphenylboronic Acid exemplifies the intersection of cutting-edge research and industrial practicality. Its adaptability across life sciences and material engineering positions it as a cornerstone in modern chemistry, answering the market's call for multifunctional reagents with high selectivity.

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