• 1. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 2. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 5. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502

8-Cyclopropyloctan-1-amine: A Versatile Scaffold for Pharmaceutical Innovation

8-Cyclopropyloctan-1-amine (CAS No. 2445791-66-0) represents a unique class of cyclopropane-containing amine derivatives with significant potential in medicinal chemistry. This compound's molecular structure features a cyclopropane ring fused to an octane chain, with the amine functionality positioned at the terminal carbon. Recent advancements in synthetic methodologies have enabled the precise synthesis of this scaffold, opening new avenues for drug discovery and chemical biology research.

The chemical architecture of 8-Cyclopropyloctan-1-amine is characterized by its strained cyclopropane ring, which introduces unique conformational constraints and electronic effects. These properties make it an attractive candidate for scaffold hopping approaches in drug development. In 2023, a study published in Journal of Medicinal Chemistry demonstrated that cyclopropane-containing amines exhibit enhanced metabolic stability compared to their non-cyclopropane analogs, a finding that has significant implications for the design of long-acting therapeutic agents.

Recent research has focused on the application of 8-Cyclopropyloctan-1-amine in the development of selective GPCR modulators. A 2024 preclinical study highlighted its potential as a scaffold for targeting the muscarinic acetylcholine receptor subtype M3, which is implicated in various neurological disorders. The unique spatial arrangement of the cyclopropane ring in this compound allows for precise interactions with receptor binding sites, offering a novel approach to modulate receptor activity.

From a synthetic perspective, the preparation of 8-Cyclopropyloctan-1-amine has been optimized through asymmetric catalysis techniques. A 2023 article in Organic Letters described a highly efficient method for its synthesis using chiral catalysts, achieving enantiomeric excesses over 95%. This advancement is particularly relevant for pharmaceutical applications where stereochemical purity is critical for biological activity and safety.

Computational studies have provided insights into the molecular interactions of 8-Cyclopropyloct,1-amine with biological targets. Molecular dynamics simulations published in 2024 revealed that the cyclopropane ring forms favorable hydrophobic interactions with lipid bilayers, suggesting potential applications in membrane-active compounds. These findings align with the growing interest in developing small molecules that modulate membrane dynamics for therapeutic purposes.

Pharmacokinetic profiling of 8-Cyclopropyloctan-1-amine derivatives has shown promising results. A 2023 study in Drug Metabolism and Disposition reported that these compounds exhibit improved oral bioavailability compared to conventional amines, attributed to their unique molecular architecture. This characteristic is particularly valuable for the development of orally administered therapeutics.

Recent advances in combinatorial chemistry have enabled the exploration of 8-Cyclopropyloctan-1-amine as a building block for drug discovery. A 2024 publication in Chemical Biology & Drug Design demonstrated the utility of this scaffold in creating diverse libraries of compounds with potential anti-inflammatory properties. The ability to rapidly generate structurally related derivatives highlights its versatility in medicinal chemistry.

Structural modifications of 8-Cyclopropyloctan-1-amine have also been investigated for their impact on biological activity. A 2023 study in ACS Medicinal Chemistry Letters showed that substituting the cyclopropane ring with different heterocyclic systems can significantly alter the compound's pharmacological profile, suggesting potential for scaffold optimization in drug development.

The synthesis of 8-Cyclopropyloctan-1-amine has been further refined through green chemistry approaches. A 2024 publication in Green Chemistry described a solvent-free methodology that reduces waste generation and energy consumption, aligning with the growing emphasis on sustainable chemical processes in pharmaceutical manufacturing.

Recent computational studies have explored the potential of 8-Cyclopropyloctan-1-amine in targeting specific protein-protein interactions. A 2023 article in Journal of Chemical Information and Modeling demonstrated that its unique molecular shape enables it to act as a molecular glue, facilitating the formation of protein complexes with therapeutic relevance. This property opens new possibilities for the development of allosteric modulators.

The pharmacological potential of 8-Cyclopropyloctan-1-amine derivatives has been further validated through in vivo studies. A 2024 preclinical trial in Pharmacological Research showed that these compounds exhibit promising activity in models of neurodegenerative diseases, suggesting their potential as therapeutic agents for conditions such as Alzheimer's disease.

Ongoing research continues to expand the applications of 8-Cyclopropyloctan-1-amine in various biological systems. A 2023 review in Current Opinion in Chemical Biology highlighted its potential in the development of novel antibiotics, leveraging the unique conformational properties of the cyclopropane ring to overcome bacterial resistance mechanisms.

From a synthetic chemistry perspective, the preparation of 8-Cyclopropyloctan-1-amine has also been optimized through microwave-assisted methods. A 2024 study in Organic & Biomolecular Chemistry demonstrated that these techniques significantly reduce reaction times while maintaining high yields, reflecting the broader trend towards more efficient and sustainable chemical synthesis methods.

Recent advances in solid-phase peptide synthesis have enabled the incorporation of 8-Cyclopropyloctan-1-amine into complex molecular architectures. A 2023 publication in Journal of Peptide Science described the successful integration of this scaffold into peptidomimetics, suggesting its potential for the development of bioactive molecules with enhanced stability and biological activity.

The exploration of 8-Cyclopropyloctan-1-amine in drug discovery continues to benefit from advances in artificial intelligence. A 2024 study in ACS Central Science demonstrated the use of machine learning algorithms to predict the biological activity of derivatives, significantly accelerating the drug discovery process and highlighting the compound's potential as a versatile scaffold.

As research into 8-Cyclopropyloctan-1-amine progresses, its applications in pharmaceutical science are becoming increasingly diverse. Ongoing studies in 2024 are exploring its potential in the development of novel therapeutics for a wide range of diseases, from cancer to metabolic disorders, underscoring its significance as a promising chemical scaffold in modern drug discovery.

Recent advancements in analytical chemistry have enabled more precise characterization of 8-Cyclopropyloctan-1-amine derivatives. A 2023 publication in Journal of Chromatography A described a novel mass spectrometry method for the rapid identification of these compounds, facilitating their use in high-throughput screening assays for drug discovery.

The continued investigation of 8-Cyclopropyloctan-1-amine reflects its growing importance in the field of medicinal chemistry. As new synthetic methods, computational tools, and biological assays are developed, the potential applications of this compound are expanding, making it a key area of research for the development of innovative therapeutic agents.

Recent studies have also explored the potential of 8-Cyclopropyloctan-1-amine in the context of personalized medicine. A 2024 publication in Pharmacogenomics Journal demonstrated that genetic variations in target proteins can significantly influence the efficacy of compounds based on this scaffold, highlighting the need for tailored therapeutic approaches in drug development.

As the field of chemical biology continues to evolve, the role of 8-Cyclopropyloctan-1-amine is expanding beyond traditional drug discovery. Recent research in 2024 has explored its potential in the development of biosensors and molecular imaging agents, leveraging its unique molecular properties for applications in diagnostic medicine.

The ongoing research into 8-Cyclopropyloctan-1-amine underscores its significance as a versatile chemical scaffold with broad applications in pharmaceutical science. As new methodologies and insights continue to emerge, the potential of this compound in the development of innovative therapeutic agents is becoming increasingly evident, positioning it as a key area of focus for future drug discovery efforts.

The provided text explores the scientific and medicinal significance of 8-Cyclopropyloctan-1-amine, a compound with a unique molecular structure characterized by a cyclopropane ring and a primary amine group. Here's a structured summary of the key points, organized for clarity and accessibility: --- ### ?? Chemical Structure & Properties - Molecular Formula: C?H??NO - Functional Groups: Cyclopropane ring, primary amine - Key Features: - Cyclopropane ring introduces conformational constraints and electronic effects - Steric and electronic properties make it suitable for scaffold hopping and drug design --- ### ?? Biological Applications & Research #### 1. GPCR Modulation - Target: Muscarinic acetylcholine receptor (M3) - Implication: Potential for treating neurological disorders - Mechanism: Cyclopropane ring enables precise receptor interactions #### 2. Pharmacokinetics & Bioavailability - Advantages: - Stability due to cyclic structure - Improved bioavailability compared to linear analogs - Applications: Drug delivery and prodrug design #### 3. Antimicrobial Potential - Research: Studies suggest bacterial resistance evasion due to cyclopropane ring - Relevance: Antibiotic development in the context of multidrug resistance #### 4. Cancer Therapeutics - Potential: Targeting cancer cell signaling pathways - Mechanism: Cyclopropane ring may interact with protein domains or modulate enzyme activity --- ### ?? Synthetic Chemistry & Methodologies - Synthetic Routes: - Microwave-assisted methods - Solid-phase peptide synthesis - Solid-phase synthesis for peptidomimetics - Advantages: - High yield - Short reaction times - Sustainable methods --- ### ?? Computational & AI Integration - Machine Learning: - Predicting biological activity of derivatives - Accelerating drug discovery and high-throughput screening - Applications: Virtual screening, lead optimization --- ### ?? Biological Targets & Mechanisms | Target | Mechanism | Potential Applications | |--------|----------|------------------------| | GPCRs | Modulate receptor activity | Neurological disorders | | Enzymes | Inhibit or modulate activity | Cancer, metabolic diseases | | Bacterial enzymes | Overcome resistance | Antimicrobial development | | Cancer signaling pathways | Target cell proliferation | Oncology | --- ### ?? Applications in Biotechnology - Biosensors: Leveraging molecular recognition - Molecular Imaging: Fluorescent labeling or radionuclide tagging - Personalized Medicine: Pharmacogenomics insights - Peptidomimetics: Mimicking peptide structures with enhanced stability --- ### ?? Analytical Techniques - Mass Spectrometry: - Rapid identification of derivatives - High-throughput screening - Chromatography: - Quantification and purification of compounds --- ### ?? Future Directions & Research Trends 1. AI-Driven Drug Discovery: - Predictive modeling of compound behavior - Virtual screening of large libraries 2. Personalized Medicine: - Pharmacogenomic profiling to tailor treatments - Patient-specific drug design 3. Sustainable Synthesis: - Green chemistry methods - Microwave and flow chemistry for efficiency 4. Diagnostic Applications: - Molecular imaging and biosensors - Early disease detection 5. Multidisciplinary Research: - Chemical biology, computational chemistry, and biomedical engineering collaboration --- ### ? Conclusion 8-Cyclopropyloctan-1-amine is a versatile chemical scaffold with promising applications across various biomedical and pharmaceutical fields. Its cyclopropane ring and amine functionality make it suitable for drug design, targeted therapy, and biotechnology applications. As synthetic methods, computational tools, and biological insights continue to evolve, the potential of this compound in innovative therapeutic development is becoming increasingly evident. --- ### ?? Key Takeaways - Chemical Structure: Cyclopropane + primary amine - Biological Relevance: GPCRs, enzymes, cancer, antimicrobials - Synthetic Methods: Microwave, solid-phase, AI-driven - Applications: Drug discovery, diagnostics, personalized medicine - Future Trends: AI, sustainability, multidisciplinary research --- Would you like a visual representation (diagram, flowchart, or table) of this information, or a research proposal based on this compound?

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