Cas no 243863-36-7 (1-[2-(difluoromethoxy)phenyl]methanamine)

1-[2-(Difluoromethoxy)phenyl]methanamine is a fluorinated aromatic amine derivative characterized by the presence of a difluoromethoxy group ortho to the aminomethyl substituent. This structural feature enhances its utility as a versatile intermediate in pharmaceutical and agrochemical synthesis, where the difluoromethoxy group can improve metabolic stability and bioavailability. The compound's electron-withdrawing properties and potential for further functionalization make it valuable in the development of bioactive molecules. Its synthesis typically involves selective fluorination and protection strategies to ensure high purity. Handling requires standard precautions for aromatic amines, including proper ventilation and protective equipment to mitigate exposure risks.
1-[2-(difluoromethoxy)phenyl]methanamine structure
243863-36-7 structure
Product Name:1-[2-(difluoromethoxy)phenyl]methanamine
CAS No:243863-36-7
MF:C8H9F2NO
MW:173.159969091415
MDL:MFCD00236229
CID:92543
PubChem ID:1514062
Update Time:2025-06-07

1-[2-(difluoromethoxy)phenyl]methanamine Chemical and Physical Properties

Names and Identifiers

    • (2-(Difluoromethoxy)phenyl)methanamine
    • 2-(Difluoromethoxy)benzylamine
    • 2-(difluoromethoxy)phenyl)methanamine
    • 1-[2-(DIFLUOROMETHOXY)PHENYL]METHANAMINE
    • 2-(3-METHYL-BENZYL)-PENTANEDIOIC ACID.
    • Benzenemethanamine,2-(difluoromethoxy)-(9CI)
    • RARECHEM AL BW 1745
    • STK672702
    • 2-(Difluoromethoxy)benzylamine, 97%
    • FT-0608782
    • FS-1150
    • [2-(difluoromethoxy)phenyl]methanamine
    • Benzenemethanamine, 2-(difluoromethoxy)-
    • AB01317601-02
    • 2-(Difluoromethoxy)benzyl amine
    • SCHEMBL192791
    • D4838
    • NCGC00322410-01
    • A817258
    • EN300-26607
    • 2-(difluoromethoxy)benzylamine, AldrichCPR
    • PB42368
    • MFCD00236229
    • 243863-36-7
    • CS-0052680
    • CK2395
    • 2-(difluoromethoxy)-benzylamine
    • AKOS000200485
    • DTXSID10947255
    • SY002983
    • [2-(Difluoromethoxy)phenyl]methylamine, 2-(Aminomethyl)-alpha,alpha-difluoroanisole, 2-(Aminomethyl)phenyl difluoromethyl ether
    • 1-[2-(difluoromethoxy)phenyl]methanamine
    • MDL： MFCD00236229
    • Inchi： 1S/C8H9F2NO/c9-8(10)12-7-4-2-1-3-6(7)5-11/h1-4,8H,5,11H2
    • InChI Key： GGXXUJUQXAOYPK-UHFFFAOYSA-N
    • SMILES： FC(OC1C=CC=CC=1CN)F

Computed Properties

  • Exact Mass: 173.06500
  • Monoisotopic Mass: 173.065
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 3
  • Complexity: 132
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 35.2A^2

Experimental Properties

  • Color/Form: Colorless or yellow liquid
  • Density: 1.2±0.1 g/cm3
  • Melting Point: No data available
  • Boiling Point: 214.1±35.0 °C at 760 mmHg
  • Flash Point: 83.3±25.9 °C
  • Refractive Index: 1.491
  • PSA: 35.25000
  • LogP: 2.44700
  • Solubility: Unable or difficult to mix
  • Sensitiveness: Air Sensitive

1-[2-(difluoromethoxy)phenyl]methanamine Security Information

1-[2-(difluoromethoxy)phenyl]methanamine Customs Data

  • HS CODE：2922199090
  • Customs Data：

    China Customs Code:

    2922199090

    Overview:

    2922199090. Other amino alcohols and their ethers,Esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

1-[2-(difluoromethoxy)phenyl]methanamine Pricemore >>

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Alichem
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TRC
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TRC
D451085-500mg
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D451085-1g
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Apollo Scientific
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