• 1. Enhanced antimicrobial treatment by a clay-based drug nanocarrier conjugated to a guanidine-rich cell penetrating peptide
  Mohammad Reza Khodabakhshi,Mohammad Hadi Baghersad RSC Adv. 2021 11 38961
• 2. Synthesis of peptides containing N-2-aminoethylglycine—‘reduction analogues’
  E. Atherton,H. D. Law,S. Moore,D. F. Elliott,R. Wade J. Chem. Soc. C 1971 3393
• 3. Improved quantification of the cyanobacteria metabolite, β-methylamino-l-alanine (BMAA) using HPLC-MS/MS detection of its dansyl chloride derivative referenced to a 15N-labeled internal standard
  Stuart W. Dyer,Joseph A. Needoba,Tawnya D. Peterson Anal. Methods 2019 11 3126
• 4. Application strategies of peptide nucleic acids toward electrochemical nucleic acid sensors
  Qingteng Lai,Wei Chen,Yanke Zhang,Zhengchun Liu Analyst 2021 146 5822
• 5. Facile synthesis of new N-(aminocycloalkylene)amino acid compounds using chiral triflate esters with N-Boc-aminopyrrolidines and N-Boc-aminopiperidines
  Gita Matulevi?iūt?,Neringa Kleizien?,Greta Ra?kauskien?,Vytas Martynaitis,Aurimas Bieliauskas,Urt? ?achlevi?iūt?,Rokas Jankauskas,Martynas R. Bartkus,Frank A. Sl?k,Algirdas ?a?kus RSC Adv. 2023 13 21570

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha amino acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Introduction to 2-((2-Aminoethyl)amino)acetic acid (CAS No. 24123-14-6)

2-((2-Aminoethyl)amino)acetic acid, identified by its Chemical Abstracts Service (CAS) number 24123-14-6, is a compound of significant interest in the field of pharmaceutical chemistry and biomedicine. This amino acid derivative has garnered attention due to its versatile structural properties and potential applications in drug design, biomaterials, and therapeutic interventions. The compound's unique molecular framework, featuring both amino and carboxyl functional groups, makes it a valuable candidate for various chemical modifications and biological interactions.

The molecular structure of 2-((2-Aminoethyl)amino)acetic acid consists of a central acetic acid backbone, with two amino groups attached at the alpha position. The presence of the (2-aminoethyl)amino side chain introduces additional reactivity and binding potential, enabling the compound to participate in hydrogen bonding, ionic interactions, and coordination chemistry. These features are particularly relevant in the context of enzyme inhibition, receptor binding, and the development of novel chelating agents.

In recent years, research on 2-((2-Aminoethyl)amino)acetic acid has been expanding into several promising areas. One notable application lies in its role as a building block for peptide mimetics and peptidomimetics. The compound's ability to mimic the structural and functional aspects of natural peptides while offering enhanced stability and bioavailability has made it a focus of interest for medicinal chemists. For instance, studies have demonstrated its utility in creating protease inhibitors that target pathogenic enzymes involved in infectious diseases and cancer.

Moreover, the chelating properties of 2-((2-Aminoethyl)amino)acetic acid have been explored in the development of targeted drug delivery systems. By coordinating with metal ions such as copper or zinc, this compound can form stable complexes that enhance the solubility and bioavailability of therapeutic agents. Such complexes have shown promise in clinical trials for treating neurodegenerative disorders and metalloproteinase-mediated diseases. The ability to fine-tune the chelating environment through structural modifications allows for precise control over drug release kinetics, improving therapeutic efficacy.

Recent advancements in computational chemistry have further illuminated the potential of 2-((2-Aminoethyl)amino)acetic acid as a scaffold for drug discovery. Molecular docking studies have identified its high affinity for various biological targets, including kinases, transcription factors, and ion channels. These findings have prompted investigations into its role as an antagonist or agonist in modulating signaling pathways associated with inflammation, neuroprotection, and metabolic disorders. The compound's dual functionality—combining both amino groups with an acetic acid moiety—provides a rich chemical space for designing molecules with tailored pharmacological profiles.

The synthesis of 2-((2-Aminoethyl)amino)acetic acid has also seen significant progress, with multiple synthetic routes being developed to achieve high yields and purity. Traditional methods involving condensation reactions between ethylene diamine and glyoxylic acid remain widely used, while newer approaches employing enzymatic catalysis offer improved selectivity and reduced environmental impact. These advancements not only facilitate large-scale production but also enable the introduction of diverse substituents for customized applications.

In the realm of biomaterials science, 2-((2-Aminoethyl)amino)acetic acid has been incorporated into hydrogels and polymers designed for biomedical applications. Its ability to form cross-linked networks while maintaining biocompatibility makes it suitable for wound healing dressings, tissue engineering scaffolds, and drug-eluting implants. Research has highlighted its role in enhancing cell adhesion and proliferation by providing a hydrated matrix rich in functional groups that can interact with cellular components.

The therapeutic potential of 2-((2-Aminoethyl)amino)acetic acid extends beyond its direct applications to include use as an intermediate in synthesizing more complex bioactive molecules. For example, it serves as a precursor for designing small-molecule inhibitors targeting specific disease pathways. Its versatility allows chemists to explore diverse modifications—such as introducing fluorinated groups or altering the length of side chains—to optimize pharmacokinetic properties like absorption, distribution, metabolism, excretion (ADME), and toxicity (Tox).

As computational biology continues to evolve, machine learning models are being employed to predict the binding affinities and pharmacological activities of derivatives of 2-((2-Aminoethyl)amino)acetic acid. These predictive tools have accelerated the discovery process by identifying promising candidates for experimental validation. Such interdisciplinary approaches highlight the compound's significance as a node in synthetic chemistry networks that bridge molecular design with biological function.

The environmental impact of utilizing 2-((2-Aminoethyl)amino)acetic acid has also been addressed through green chemistry principles. Efforts to develop solvent-free reactions or use renewable feedstocks have reduced waste generation while maintaining high product yields. These sustainable practices align with global initiatives to promote environmentally responsible pharmaceutical manufacturing.

In conclusion, 2-((2-Aminoethyl)amino)acetic acid (CAS No. 24123-14-6 ) represents a multifaceted compound with broad applications across pharmaceuticals,biomaterials,and biomedicine research . Its unique structural features continue to inspire innovative research ,with ongoing studies exploring its potential in treating complex diseases ,enhancing material performance ,and advancing sustainable chemical practices . As our understanding deepens ,the role this molecule will play in future therapeutics is bound to expand further .

• 38011-25-5(Glycine, N,N-1,2-ethanediylbis-, disodium salt)
• 63636-03-3(Glycine, N,N'-1,2-ethanediylbis-, ammonium salt (9CI))
• 32575-57-8(Cupric ethylenediamine diacetate)
• 5657-17-0(Ethylenediamine-N,N'-diacetic acid)
• 67-43-6(Pentetic acid)
• 29977-10-4(Cobalt,[[N,N'-1,2-ethanediylbis[glycinato-kN,kO]](2-)]-)
• 29977-13-7(Cadmium,[[N,N'-1,2-ethanediylbis[glycinato-kN,kO]](2-)]-, (T-4)-)
• 25240-38-4(2-(2-aminoethyl)aminoacetic acid dihydrochloride)
• 157823-58-0(1,4,7,10-Tetraazabicyclo[5.5.2]tetradecane-4,10-diacetic acid)
• 24123-05-5(2-((2-Aminoethyl)amino)acetic acid hydrochloride)