• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 3. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 4. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 5. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378

Research Brief on Tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate (CAS: 240401-28-9): Recent Advances and Applications

Tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate (CAS: 240401-28-9) is a spirocyclic compound that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its unique structural features and potential therapeutic applications. Recent studies have explored its utility as a key intermediate in the synthesis of bioactive molecules, particularly in the development of novel pharmaceuticals targeting neurological disorders and infectious diseases. This research brief aims to summarize the latest findings related to this compound, highlighting its synthetic routes, biological activities, and emerging applications.

The compound's spirocyclic scaffold, characterized by a 7-azaspiro[3.5]nonane core, offers a rigid yet flexible framework that is highly amenable to structural modifications. This property has been leveraged in the design of drug candidates with improved pharmacokinetic profiles. Recent synthetic methodologies have focused on optimizing the yield and purity of Tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate, with particular emphasis on green chemistry approaches to reduce environmental impact. For instance, a 2023 study demonstrated a catalytic asymmetric synthesis route that achieved high enantioselectivity, paving the way for its use in chiral drug development.

In terms of biological activity, Tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate has shown promise as a precursor for inhibitors of enzymes such as proteases and kinases, which are critical targets in cancer and inflammatory diseases. A recent publication in the Journal of Medicinal Chemistry reported its incorporation into a series of novel kinase inhibitors, exhibiting nanomolar potency against specific cancer cell lines. Additionally, its hydroxyl group provides a handle for further derivatization, enabling the attachment of various pharmacophores to enhance target specificity.

Beyond its role in drug discovery, this compound has also been investigated for its potential in chemical biology tools. For example, researchers have utilized its spirocyclic structure to develop fluorescent probes for imaging cellular processes. A 2024 study highlighted its use in tracking protein-protein interactions in real-time, offering insights into dynamic biological systems. Such applications underscore its versatility beyond traditional medicinal chemistry.

In conclusion, Tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate (CAS: 240401-28-9) represents a valuable building block in modern drug discovery and chemical biology. Its synthetic accessibility, coupled with its adaptable structure, positions it as a key player in the development of next-generation therapeutics and research tools. Future research directions may include exploring its utility in targeted drug delivery systems and as a scaffold for multifunctional bioactive molecules.

• 918644-73-2(tert-butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate)
• 1338247-76-9(tert-butyl 1-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate)
• 1419101-54-4(tert-butyl 2-hydroxy-6-azaspiro[3.5]nonane-6-carboxylate)
• 358625-61-3(tert-butyl 4-(2-hydroxy-2-methylpropyl)piperidine-1-carboxylate)
• 919360-50-2(tert-butyl 4-(3-hydroxybutyl)piperidine-1-carboxylate)
• 1126084-33-0(tert-butyl 4-(2-hydroxypropyl)piperidine-1-carboxylate)
• 1445951-30-3(Tert-Butyl 2-Hydroxy-7-Azaspiro[3.6]Decane-7-Carboxylate)
• 1370210-93-7(tert-Butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane-7-carboxylate)
• 1206830-71-8(tert-butyl 4-(1R)-1-hydroxyethylpiperidine-1-carboxylate)
• 374794-88-4(1-Piperidinecarboxylic acid, 4-hydroxy-4-(3-hydroxypropyl)-,1,1-dimethylethyl ester)