• 1. Synthesis and properties of adducts of a hindered amine and 2-hydroxyphenylbenzotriazole as novel polymer stabilizers
  Vladimir Bojinov Photochem. Photobiol. Sci. 2002 1 340
• 2. Preparation of functionalized zirconium phosphate and its effect on the flame retardancy of silicone rubber
  Yajun Zhang,Xingrong Zeng,Xuejun Lai,Hongqiang Li RSC Adv. 2018 8 111
• 3. Preparation of functionalized zirconium phosphate and its effect on the flame retardancy of silicone rubber
  Yajun Zhang,Xingrong Zeng,Xuejun Lai,Hongqiang Li RSC Adv. 2018 8 111
• 4. Self photostabilizing UV-durable MWCNT/polymer nanocomposites
  Sunil P. Lonkar,Omkar S. Kushwaha,Andreas Leuteritz,Gert Heinrich,R. P. Singh RSC Adv. 2012 2 12255
• 5. 11. Synthetic mydriatics
  A. H. Ford-Moore,H. R. Ing J. Chem. Soc. 1947 55

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Introduction to 1,2,2,6,6-Pentamethylpiperidin-4-ol (CAS No. 2403-89-6)

1,2,2,6,6-Pentamethylpiperidin-4-ol, identified by its Chemical Abstracts Service (CAS) number 2403-89-6, is a significant compound in the realm of organic chemistry and pharmaceutical research. This compound belongs to the piperidine class of heterocyclic amines, characterized by a six-membered ring containing one nitrogen atom. The presence of multiple methyl groups at specific positions enhances its structural stability and reactivity, making it a valuable intermediate in synthetic chemistry.

The molecular structure of 1,2,2,6,6-Pentamethylpiperidin-4-ol consists of a central piperidine ring substituted with five methyl groups and an hydroxyl group at the 4-position. This arrangement imparts unique electronic and steric properties that make it useful in various chemical transformations. The compound’s high symmetry and stability contribute to its utility as a building block in the synthesis of more complex molecules.

In recent years, 1,2,2,6,6-Pentamethylpiperidin-4-ol has garnered attention in the pharmaceutical industry due to its potential applications as a chiral auxiliary and ligand in asymmetric synthesis. The compound’s ability to facilitate enantioselective reactions has been explored in the development of novel drugs targeting various therapeutic areas. For instance, researchers have utilized derivatives of this compound to enhance the efficiency of catalytic processes in drug synthesis.

One of the most compelling aspects of 1,2,2,6,6-Pentamethylpiperidin-4-ol is its role in medicinal chemistry. The hydroxyl group at the 4-position provides a reactive site for further functionalization, enabling the creation of diverse pharmacophores. This flexibility has been leveraged in the design of molecules with improved pharmacokinetic properties and reduced side effects. Recent studies have demonstrated its efficacy in the synthesis of compounds with potential applications in treating neurological disorders and inflammatory conditions.

The compound’s stability under various reaction conditions makes it an attractive candidate for industrial-scale applications. Its resistance to degradation under thermal and acidic conditions ensures consistent yields in large-scale syntheses. This reliability is crucial for pharmaceutical manufacturers who require high-purity intermediates for drug production. Additionally, the ease with which 1,2,2,6,6-Pentamethylpiperidin-4-ol can be purified and handled further enhances its appeal as a synthetic intermediate.

From an academic perspective, 1,2,2,6,6-Pentamethylpiperidin-4-ol has been a subject of extensive research in computational chemistry and molecular modeling. These studies aim to elucidate its reactivity and interaction with other molecules at a quantum mechanical level. Such insights are invaluable for predicting reaction outcomes and optimizing synthetic pathways. The integration of experimental data with computational methods has led to a deeper understanding of how this compound behaves in different chemical environments.

The pharmaceutical industry has also explored the use of 1,2,2,6,6-Pentamethylpiperidin-4-ol as a precursor for bioactive molecules. Researchers have synthesized analogs of this compound that exhibit potent biological activity against targets such as enzymes and receptors involved in disease pathways. For example, modifications to the methyl groups have been shown to alter binding affinities and selectivity profiles significantly. This underscores the importance of structural optimization in drug discovery.

In conclusion,1 , 2 , 2 , 6 , 6 -Pentamethylpip eridine -4 -ol (CAS No .2403 -89 -6) is a versatile and highly valued compoun d i n organic an d pharmaceutical chemistry . Its unique structural features an d reactivity make i t an indispensable tool i n synthetic s ystems an d drug development . With ongoing research uncovering new applications an d refining synthetic methodologies , th e significance o f this compoun d is likely to grow further . p >

• 2403-88-5(2,2,6,6-tetramethylpiperidin-4-ol)
• 54352-66-8(Poranthericin)
• 39027-76-4(Poranthericine)
• 59529-58-7(4-Piperidinol, 1-butyl-2,2,6,6-tetramethyl-)
• 61683-18-9(4-Piperidinol, 2,6-diethyl-1,2,3,6-tetramethyl-)
• 52722-86-8(1-(2-Hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-ol)
• 2038-40-6(9-Azabicyclo[3.3.1]nonan-3-ol,9-methyl-, (3-endo)-)
• 541549-07-9(4-Piperidinol, 1-methyl-2-(1-methylethyl)-, (2R,4S)-rel- (9CI))
• 929555-64-6(8-Azadispiro[6.1.6.3]octadecan-17-ol)
• 125797-64-0(2H-Quinolizin-2-ol,octahydro-6,9-dimethyl-4-(1-methylethyl)-, (2R,4R,6S,9S,9aS)-rel-(+)-)