• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolecarboxylic acids and derivatives

Recent Advances in the Application of 4-Chloro-1-methyl-1H-indole-2-carboxylic acid (CAS: 23967-44-4) in Chemical Biology and Pharmaceutical Research

The compound 4-Chloro-1-methyl-1H-indole-2-carboxylic acid (CAS: 23967-44-4) has recently emerged as a key scaffold in medicinal chemistry and drug discovery. This indole derivative has attracted significant attention due to its versatile pharmacological properties and its role as a building block for more complex bioactive molecules. Recent studies have explored its potential in various therapeutic areas, including anti-inflammatory, anticancer, and antimicrobial applications.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the compound's effectiveness as a precursor for novel kinase inhibitors. Researchers utilized 4-Chloro-1-methyl-1H-indole-2-carboxylic acid to develop a series of potent and selective inhibitors targeting specific tyrosine kinases involved in cancer progression. The study highlighted the compound's optimal molecular geometry for binding to the ATP pocket of these kinases, with modifications at the carboxylic acid position yielding derivatives with improved pharmacokinetic properties.

In the field of anti-infective research, a team at the University of Cambridge reported in Bioorganic & Medicinal Chemistry Letters (2024) on the antimicrobial activity of 4-Chloro-1-methyl-1H-indole-2-carboxylic acid derivatives. The study found that certain halogenated analogs exhibited remarkable activity against drug-resistant bacterial strains, particularly MRSA and ESBL-producing E. coli. The presence of the chloro group at the 4-position was identified as crucial for maintaining antibacterial potency while reducing cytotoxicity against mammalian cells.

The compound's role in neurodegenerative disease research has also been explored. A recent Nature Communications paper (2024) described its incorporation into small molecules targeting α-synuclein aggregation in Parkinson's disease. The indole core provided optimal π-stacking interactions with amyloid fibrils, while the carboxylic acid moiety enabled salt bridge formation with key lysine residues. This dual interaction mechanism showed promise in preventing protein misfolding without disrupting normal α-synuclein function.

From a synthetic chemistry perspective, advances in the production of 4-Chloro-1-methyl-1H-indole-2-carboxylic acid have been significant. A 2024 Organic Process Research & Development publication detailed an improved, greener synthesis route using continuous flow chemistry, achieving higher yields (82%) and reduced environmental impact compared to traditional batch methods. This development is particularly important as demand for the compound increases in pharmaceutical manufacturing.

Looking forward, the unique structural features of 4-Chloro-1-methyl-1H-indole-2-carboxylic acid continue to inspire novel drug design strategies. Its balanced lipophilicity, molecular rigidity, and multiple sites for derivatization make it an attractive starting point for fragment-based drug discovery. Several pharmaceutical companies have included derivatives of this compound in their preclinical pipelines, particularly for oncology and CNS disorders, suggesting its importance will likely grow in coming years.

• 16136-58-6(1-methyl-1H-indole-2-carboxylic acid)
• 1082766-49-1(7-Chloro-1-methyl-1H-indole-2-carboxylic acid)
• 59908-53-1(Ethyl 5-chloro-1-methyl-1H-indole-2-carboxylate)
• 680569-83-9(6-Chloro-1-methyl-1H-indole-2-carboxylic acid)
• 23967-51-3(1,4-Dimethyl-1H-indole-2-carboxylic acid)
• 1043420-84-3(3-chloro-1-methyl-1H-Indole-2-carboxylic acid)
• 59908-47-3(5-Chloro-1-methyl-1H-indole-2-carboxylic acid)
• 148356-79-0(Methyl 5-chloro-1-methyl-1H-indole-2-carboxylate)
• 893730-44-4(1,6-Dimethyl-1H-indole-2-carboxylic acid)
• 216210-59-2(1,5-Dimethyl-1H-indole-2-carboxylic acid)