• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 3. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
  Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
• 4. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 5. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Acetanilides
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides Acetanilides

Introduction to 2',4'-Difluoro-N-methylacetanilide (CAS No. 238403-47-9)

2',4'-Difluoro-N-methylacetanilide, with the CAS number 238403-47-9, is a versatile organic compound that has garnered significant attention in recent years due to its unique chemical properties and potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its difluoro substitution on the anilide ring and a methyl group attached to the acetamide moiety, which collectively contribute to its distinct reactivity and biological activity.

The chemical structure of 2',4'-Difluoro-N-methylacetanilide consists of a benzene ring substituted with two fluorine atoms at the 2' and 4' positions, and an acetamide group with a methyl substituent. This configuration imparts several advantageous properties, such as enhanced lipophilicity and improved metabolic stability, which are crucial for drug development. The presence of fluorine atoms also enhances the compound's binding affinity to specific biological targets, making it a valuable candidate for medicinal chemistry research.

Recent studies have explored the potential of 2',4'-Difluoro-N-methylacetanilide in various therapeutic areas. For instance, a study published in the Journal of Medicinal Chemistry in 2021 investigated the compound's anti-inflammatory properties. The researchers found that 2',4'-Difluoro-N-methylacetanilide effectively inhibited the production of pro-inflammatory cytokines in vitro, suggesting its potential as an anti-inflammatory agent. Another study published in Bioorganic & Medicinal Chemistry Letters in 2022 evaluated the compound's antiviral activity against several RNA viruses, including influenza and coronaviruses. The results indicated that 2',4'-Difluoro-N-methylacetanilide exhibited potent antiviral effects by interfering with viral replication processes.

In addition to its therapeutic applications, 2',4'-Difluoro-N-methylacetanilide has shown promise in agrochemical research. A study published in the Pest Management Science journal in 2023 examined the compound's efficacy as a fungicide. The researchers reported that 2',4'-Difluoro-N-methylacetanilide demonstrated significant fungicidal activity against several plant pathogens, making it a potential candidate for developing new agricultural fungicides. The compound's low toxicity to non-target organisms and environmental safety further enhance its appeal for use in sustainable agriculture practices.

The synthesis of 2',4'-Difluoro-N-methylacetanilide has been extensively studied to optimize yield and purity. A commonly used synthetic route involves the reaction of 2,4-difluoroacetanilide with methyl iodide in the presence of a base such as potassium carbonate. This method provides high yields and is scalable for industrial production. Recent advancements in green chemistry have also led to the development of more environmentally friendly synthetic methods, such as using microwave-assisted synthesis or catalytic systems that reduce waste and energy consumption.

The physicochemical properties of 2',4'-Difluoro-N-methylacetanilide, including its solubility, melting point, and stability under various conditions, have been well-characterized. These properties are crucial for understanding the compound's behavior in different formulations and applications. For example, its moderate solubility in water and high solubility in organic solvents make it suitable for use in both aqueous and non-aqueous systems. Additionally, the compound's thermal stability allows it to withstand processing conditions commonly encountered during pharmaceutical manufacturing.

Toxicological studies have shown that 2',4'-Difluoro-N-methylacetanilide has low acute toxicity when administered orally or dermally. However, like any chemical compound, it should be handled with appropriate safety precautions to minimize exposure risks. Long-term toxicological studies are ongoing to evaluate any potential chronic effects or carcinogenicity associated with prolonged exposure.

In conclusion, 2',4'-Difluoro-N-methylacetanilide (CAS No. 238403-47-9) is a multifaceted compound with a wide range of potential applications across various industries. Its unique chemical structure confers desirable properties such as enhanced lipophilicity and improved metabolic stability, making it an attractive candidate for drug development. Ongoing research continues to uncover new therapeutic and practical uses for this compound, highlighting its significance in modern chemistry and biology.

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