Cas no 2375-03-3 (6α-Methylprednisolone 21-hemisuccinate sodium salt)

6α-Methylprednisolone 21-hemisuccinate sodium salt is a water-soluble derivative of methylprednisolone, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. The 21-hemisuccinate modification enhances solubility in aqueous solutions, making it suitable for intravenous or intramuscular administration in research and pharmaceutical applications. This compound retains the biological activity of methylprednisolone, including its ability to modulate gene expression and inhibit inflammatory mediators. The sodium salt form further improves stability and handling. Its solubility profile and consistent bioavailability make it a preferred choice for experimental studies requiring precise dosing or controlled delivery systems. The compound is widely utilized in pharmacological research, particularly in inflammation and immune response studies.
6α-Methylprednisolone 21-hemisuccinate sodium salt structure
2375-03-3 structure
Product Name:6α-Methylprednisolone 21-hemisuccinate sodium salt
CAS No:2375-03-3
MF:C26H33NaO8
MW:496.525199651718
MDL:MFCD00152612
CID:42842
PubChem ID:23680530
Update Time:2025-10-29

6α-Methylprednisolone 21-hemisuccinate sodium salt Chemical and Physical Properties

Names and Identifiers

    • 6alpha-Methylprednisolone sodium succinate
    • (6alpha,11beta)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-Pregna-1,4-diene-3,20-dione monosodium salt
    • 6α-Methylprednisolone 21-Hemisuccinate Sodium Salt
    • 6a-Methylprednisolone 21-succinate sodium
    • 6α-Methylprednisolone 21-hemisuccinate (sodium salt)
    • 6-Methylprednisolone succinate sodium
    • Methylprednisolone sodium succinate
    • METHYLPREDNISOLONE SODIUM SUCCINATE,USP27
    • Nirypan solubile
    • sodium 4-{2-[(1R,3aS,3bS,5S,9aR,9bS,10S,11aS)-1,10-dihydroxy-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-4-oxobutanoate
    • Prednol (inj.)
    • sodium;4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
    • AKOS015962276
    • NCGC00185763-01
    • Ubrason solubile
    • METHYLPREDNISOLONE 21-SUCCINATE SODIUM SALT [MI]
    • CHEMBL1201081
    • MFCD00152612
    • 6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate
    • Succinic acid, 21-monoester with 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione, monosodium salt
    • A-methapred (TN)
    • FQISKWAFAHGMGT-SGJOWKDISA-M
    • NSC 48989
    • Firmacort Fiale
    • Methylprednisolone succinate
    • Methylprednisolone 21-succinate sodium salt
    • Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21- (hydrogen succinate), monosodium salt
    • 2375-03-3
    • 6alpha-Methylprednisolone sodium hemisuccinate
    • 6alpha-Methylprednisolone 21-sodium succinate
    • METHYLPREDNISOLONE SODIUM SUCCINATE (USP IMPURITY)
    • D00751
    • Cryosolona
    • Metypresol
    • Ubrason solubile (inj.)
    • Methylprednisolone sodium succinate [USP:JAN]
    • DTXSID2023303
    • NSC-48989
    • 6AfAE'A centa' notA inverted exclamation markAfasA'A
    • Sodium methylprednisolone succinate
    • D95085
    • Corticel
    • Medrate [inj.]
    • Prednisolone, 6alpha-methyl-, succinate, sodium salt
    • Methylprednisolone Hydrogen Succinate Sodium Salt
    • Methylprednisolone succinate sodium salt
    • SCHEMBL40947
    • EINECS 219-156-8
    • METHYLPREDNISOLONE SODIUM SUCCINATE [JAN]
    • W-107376
    • Prednol
    • 11beta,17,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione 21-sodium succinate
    • Methylprednisolone sodium succinate (JAN/USP)
    • NSC48989
    • CS-4582
    • 6-Methylprednisolone 21-hemisuccinate (sodium salt)
    • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(sodium succinate)
    • AS-74917
    • Methylprednisolone sodium succinate;6-Methylprednisolone succinate sodium
    • Asmacortone
    • Prednol [inj.]
    • CAS-2375-03-3
    • A-Methylprednisolone 21-hemisuccinate Sodium
    • METHYLPREDNISOLONE SODIUM SUCCINATE (USP MONOGRAPH)
    • Methylprodnisolone Sodium Succinate
    • Metypred (inj.)
    • Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6.alpha.,11.beta.)-
    • 6alpha-Methylprednisolone 21-hemisuccinate sodium salt
    • METHYLPREDNISOLONE SODIUM SUCCINATE [MART.]
    • METHYLPREDNISOLONE SODIUM SUCCINATE [WHO-DD]
    • Methylprednisolone sodium succinate (USP:JAN)
    • Lemod Solu
    • 6alpha-Methylprednisolone 21-sodium hemisuccinate
    • 6-alpha-Methylprednisolone sodium succinate
    • METHYLPREDNISOLONE SODIUM SUCCINATE [USP MONOGRAPH]
    • Prednilem
    • Tox21_113527
    • Cryosolona [inj.]
    • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-(hydrogen succinate), monosodium salt
    • Medrate (inj.)
    • Sodium Succinate, Methylprednisolone
    • sodium 4-{[(6alpha,11beta)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoate
    • Metypred
    • 6alpha-Methylpregnisolone 21-sodium succinate
    • Methylprednisolone sodium hemisuccinate
    • Solu-Medrone
    • HY-B1060
    • 11-beta,17,21-Trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione 21-(sodium succinate)
    • METHYLPREDNISOLONE SODIUM SUCCINATE [VANDF]
    • M-6-P
    • SOLU-MEDROL(R) METHYLPREDNISOLONE SODIUM SUCCINAT
    • Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21-(hydrogen succinate), monosodium salt
    • AfAE'Adaggeratrade mark?-Methylprednisolone 21-hemisuccinate (sodium salt)
    • Solumedrol
    • Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6alpha,11beta)-
    • U 9088
    • A-Methylprednisolone 21-hemisuccinate (sodium salt)
    • Solu-medrol (TN)
    • Omnacortil
    • DTXCID103303
    • Sol Melcort
    • CHEBI:6890
    • Cryosolona (inj.)
    • UNII-LEC9GKY20K
    • Solu Moderin
    • METHYLPREDNISOLONE SODIUM SUCCINATE (MART.)
    • METHYLPREDNISOLONE SODIUM SUCCINATE [ORANGE BOOK]
    • Urbason solubile
    • Solu-Medrol
    • Q27282942
    • LEC9GKY20K
    • 6
    • Solu Medrol
    • Ubrason solubile [inj.]
    • METHYLPREDNISOLONE SODIUM SUCCINATE [USP IMPURITY]
    • NS00083306
    • Metypred [inj.]
    • 6a-Methylprednisolone 21-Hemisuccinate Sodium Salt
    • Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodiumsalt, (6a,11b)-
    • 6α-Methylprednisolone 21-hemisuccinate sodium salt
    • MDL： MFCD00152612
    • Inchi： 1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
    • InChI Key： FQISKWAFAHGMGT-SGJOWKDISA-M
    • SMILES： [Na+].O[C@]1(C(COC(CCC(=O)[O-])=O)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(C=C[C@]4(C)[C@H]3[C@H](C[C@@]21C)O)=O

Computed Properties

  • Exact Mass: 496.20700
  • Monoisotopic Mass: 496.20731229g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 35
  • Rotatable Bond Count: 7
  • Complexity: 988
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 8
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 141?2

Experimental Properties

  • Melting Point: >186°C (dec.)
  • Boiling Point: 689.6°C at 760 mmHg
  • PSA: 141.03000
  • LogP: 0.88460

6α-Methylprednisolone 21-hemisuccinate sodium salt Security Information

  • Signal Word：Warning
  • Hazard Statement： H302-H315-H319-H335
  • Warning Statement： P261-P305+P351+P338
  • WGK Germany：3
  • Hazard Category Code： R61;R40
  • Safety Instruction： 53-22-36/37/39-45
  • RTECS：TU4154060
  • Hazardous Material Identification： T
  • Safety Term：S53;S22;S36/37/39;S45
  • Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
  • Risk Phrases：R61; R40

6α-Methylprednisolone 21-hemisuccinate sodium salt Pricemore >>

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6α-Methylprednisolone 21-hemisuccinate sodium salt Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:2375-03-3)Succinate
Order Number:sfd11312
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally

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Additional information on 6α-Methylprednisolone 21-hemisuccinate sodium salt

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6α-Methylprednisolone 21-Hemisuccinate Sodium Salt: A Comprehensive Overview

The compound with CAS No. 2375-03-3, known as 6α-Methylprednisolone 21-hemisuccinate sodium salt, is a synthetic glucocorticoid derivative that has garnered significant attention in the fields of pharmacology and medicine. This compound is a modified version of prednisolone, a widely used corticosteroid, and its structural modifications enhance its pharmacokinetic properties and therapeutic efficacy. The 6α-methyl substitution and the 21-hemisuccinate sodium salt functional groups play pivotal roles in determining its biological activity and stability.

6α-Methylprednisolone 21-hemisuccinate sodium salt is primarily utilized in the treatment of inflammatory and autoimmune disorders due to its potent anti-inflammatory and immunosuppressive properties. Recent studies have highlighted its efficacy in managing conditions such as rheumatoid arthritis, asthma, and certain dermatological conditions. The compound's ability to suppress cytokine production and modulate immune responses makes it a valuable therapeutic agent in modern medicine.

From a chemical standpoint, the 6α-methyl group enhances the compound's lipophilicity, which improves its absorption and bioavailability. The 21-hemisuccinate sodium salt moiety serves to stabilize the molecule and facilitate its solubility in aqueous solutions, which is crucial for its formulation into various pharmaceutical preparations. These structural features contribute to the compound's favorable pharmacokinetic profile, enabling it to achieve optimal therapeutic concentrations with minimal side effects.

Recent advancements in research have focused on optimizing the delivery mechanisms of 6α-Methylprednisolone 21-hemisuccinate sodium salt to enhance its efficacy further. For instance, studies have explored the use of nanotechnology-based delivery systems, such as lipid nanoparticles and polymeric micelles, to improve targeted drug delivery and reduce systemic side effects. These innovations hold promise for expanding the clinical applications of this compound.

In addition to its therapeutic uses, 6α-Methylprednisolone 21-hemisuccinate sodium salt has been investigated for its potential in regenerative medicine. Preclinical studies have demonstrated its ability to promote tissue repair by modulating inflammatory responses and enhancing angiogenesis. This dual functionality positions it as a versatile agent with applications beyond traditional corticosteroid therapy.

The synthesis of 6α-Methylprednisolone 21-hemisuccinate sodium salt involves a multi-step process that includes hydroxylation, methylation, and esterification reactions. Researchers have recently developed more efficient synthetic pathways that reduce production costs and improve yield, making this compound more accessible for large-scale manufacturing.

From an environmental perspective, the ecological impact of 6α-Methylprednisolone 21-hemisuccinate sodium salt has been a growing concern. Studies have shown that improper disposal of pharmaceutical waste can lead to contamination of water bodies, potentially affecting aquatic ecosystems. Efforts are underway to develop sustainable practices for the production and disposal of this compound to mitigate its environmental footprint.

In conclusion, 6α-Methylprednisolone 21-hemisuccinate sodium salt (CAS No. 2375-03-3) is a significant advancement in glucocorticoid therapy, offering enhanced efficacy and reduced side effects compared to traditional corticosteroids. Its versatility in treating inflammatory diseases, combined with ongoing research into novel delivery systems and applications, underscores its importance in contemporary medicine.

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Suzhou Senfeida Chemical Co., Ltd
(CAS:2375-03-3)Succinate
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Purity:99.9%
Quantity:200kg
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