• 1. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 2. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 4. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 5. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Hydrazines and derivatives Alkylhydrazines

Introduction to (2-methylpropyl)hydrazine hydrochloride (CAS No. 237064-47-0)

(2-methylpropyl)hydrazine hydrochloride, with the chemical formula C₅H₁₂N₂HCl, is a significant compound in the field of pharmaceutical and chemical research. This compound, identified by its CAS number CAS No. 237064-47-0, has garnered attention due to its unique structural properties and potential applications in various scientific domains.

The molecular structure of (2-methylpropyl)hydrazine hydrochloride consists of a hydrazine moiety attached to an isobutyl group, forming a salt with hydrochloric acid. This configuration imparts specific reactivity and makes it a valuable intermediate in synthetic chemistry. The compound's ability to participate in nucleophilic addition reactions and condensation reactions has been widely explored in the development of novel pharmaceuticals and agrochemicals.

In recent years, significant research has focused on the applications of (2-methylpropyl)hydrazine hydrochloride in medicinal chemistry. Its hydrazine group is particularly noteworthy, as it can engage in various chemical transformations that are pivotal for drug synthesis. For instance, it has been utilized in the preparation of hydrazones and hydrazides, which are key intermediates in the synthesis of antitubercular and antiviral agents.

One of the most compelling aspects of (2-methylpropyl)hydrazine hydrochloride is its role in the development of bioactive molecules. Researchers have leveraged its structural features to design compounds with enhanced pharmacological properties. Notably, studies have demonstrated its utility in creating derivatives that exhibit significant antimicrobial activity. These derivatives have shown promise in preliminary clinical trials, particularly against resistant bacterial strains.

The compound's reactivity also makes it a valuable tool in organic synthesis. It serves as a precursor for more complex molecules, enabling chemists to construct intricate scaffolds with potential therapeutic benefits. The ability to modify its structure allows for the exploration of diverse chemical space, which is crucial for discovering new drugs with improved efficacy and reduced side effects.

Advances in computational chemistry have further enhanced the understanding of (2-methylpropyl)hydrazine hydrochloride's behavior. Molecular modeling studies have provided insights into its interactions with biological targets, aiding in the rational design of drugs. These computational approaches complement experimental work, offering a more comprehensive view of the compound's potential applications.

In addition to its pharmaceutical applications, (2-methylpropyl)hydrazine hydrochloride has found utility in materials science. Its ability to form coordination complexes with metal ions has been explored for applications in catalysis and material design. These complexes often exhibit unique properties that can be harnessed for industrial processes or advanced materials development.

The synthesis of (2-methylpropyl)hydrazine hydrochloride itself is an area of active research. Chemists have developed efficient synthetic routes that improve yield and purity, making it more accessible for industrial-scale production. These methods often involve multi-step processes that highlight the compound's versatility as a building block.

Evaluation of (2-methylpropyl)hydrazine hydrochloride's safety profile is another critical aspect of its application. While it is not classified as a hazardous material under standard regulatory frameworks, proper handling procedures must be followed to ensure safety during storage and transportation. Research into its environmental impact has also been conducted to assess its persistence and degradation pathways.

The future prospects for (2-methylpropyl)hydrazine hydrochloride are promising, given its broad utility across multiple scientific disciplines. Ongoing research aims to uncover new applications and optimize existing ones. Collaborative efforts between academia and industry are expected to drive innovation, leading to novel compounds that address unmet medical needs.

• 3711-37-3(Hydrazine,1,2-bis(2-methylpropyl)-)
• 31820-30-1(Neopentylhydrazine hydrochloride)
• 1177323-30-6((2,2-Dimethylpropyl)hydrazine Dihydrochloride)
• 809282-61-9((Cyclopropylmethyl)hydrazine dihydrochloride)
• 1181457-83-9((cyclopropylmethyl)hydrazine hydrochloride)
• 145295-89-2(1-Isobutylhydrazine hydrochloride)
• 42504-87-0((2-methylpropyl)hydrazine)
• 70629-59-3(Propylhydrazine dihydrochloride)
• 66557-70-8(Neopentylhydrazine)
• 56795-66-5(Propylhydrazine hydrochloride)