• 1. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 2. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 3. An apparatus for determining small amounts of alchohol in sour milk and urine
  Analyst, 1964,89, 272-275
• 4. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

1-(2-Chlorobenzenesulfonyl)Piperazine: A Comprehensive Overview

1-(2-Chlorobenzenesulfonyl)Piperazine (CAS No. 233261-84-2) is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound, characterized by its unique structure, has garnered attention due to its potential applications in drug development and material science. The molecule consists of a piperazine ring, a six-membered saturated ring with two nitrogen atoms, substituted with a 2-chlorobenzenesulfonyl group. This substitution imparts distinct chemical and physical properties, making it a valuable compound for various research and industrial purposes.

The synthesis of 1-(2-Chlorobenzenesulfonyl)Piperazine involves a series of well-established organic reactions. Typically, the preparation begins with the sulfonation of 2-chlorobenzene using sulfuric acid or other sulfonating agents. The resulting 2-chlorobenzenesulfonic acid is then converted into its corresponding sulfonyl chloride by treatment with thionyl chloride (SOCl?). In the final step, the sulfonyl chloride reacts with piperazine in the presence of a base to form the target compound. This multi-step synthesis ensures high purity and structural integrity, which are critical for its intended applications.

Recent studies have highlighted the potential of 1-(2-Chlorobenzenesulfonyl)Piperazine in pharmacology, particularly in the development of kinase inhibitors. Kinases are enzymes that play a pivotal role in cellular signaling pathways, and their dysregulation is associated with various diseases, including cancer and inflammatory disorders. The sulfonyl group in the compound acts as a bioisostere for phosphate groups, making it an ideal candidate for targeting kinase active sites. Preclinical studies have demonstrated that this compound exhibits potent inhibitory activity against several kinases, suggesting its potential as a lead molecule for drug development.

In addition to its pharmacological applications, 1-(2-Chlorobenzenesulfonyl)Piperazine has shown promise in material science. The compound's ability to form stable metal-organic frameworks (MOFs) has been explored in recent research. MOFs are porous materials with applications in gas storage, catalysis, and sensing technologies. The piperazine moiety in the compound provides coordination sites for metal ions, while the sulfonyl group contributes to thermal stability and porosity. These properties make it a valuable building block for constructing advanced MOFs with tailored functionalities.

The chemical stability of 1-(2-Chlorobenzenesulfonyl)Piperazine is another area of interest. Studies have shown that the compound exhibits excellent thermal stability, retaining its structure up to temperatures exceeding 300°C. This property is advantageous for industrial applications where high-temperature conditions are encountered. Furthermore, the compound demonstrates moderate solubility in common organic solvents such as dichloromethane and acetonitrile, which facilitates its use in solution-based reactions and formulations.

From an environmental perspective, the biodegradation and toxicity profiles of 1-(2-Chlorobenzenesulfonyl)Piperazine have been studied to assess its safety for industrial use. Research indicates that the compound undergoes slow biodegradation under aerobic conditions, suggesting that it may persist in certain environments if not properly managed. However, acute toxicity studies reveal that it has low toxicity to aquatic organisms at environmentally relevant concentrations, which aligns with its potential use in sustainable chemical processes.

In conclusion, 1-(2-Chlorobenzenesulfonyl)Piperazine (CAS No. 233261-84-2) is a versatile compound with diverse applications across multiple disciplines. Its unique structure enables it to serve as a valuable tool in drug discovery, material science, and chemical engineering. As research continues to uncover new insights into its properties and potential uses, this compound is poised to play an increasingly important role in advancing scientific and technological innovations.

• 731003-83-1(1-(4-bromo-2-chlorobenzenesulfonyl)piperazine)
• 16017-53-1(1-(4-Chloro-benzenesulfonyl)-piperazine)
• 13170-83-7(Piperazine, 1,4-bis[(4-chlorophenyl)sulfonyl]-)
• 203521-17-9(1-((6-Chloronaphthalen-2-yl)sulfonyl)piperazine)
• 1353966-37-6(1-((2,4-Dichlorophenyl)sulfonyl)piperazine hydrochloride)
• 1172060-75-1(1-[(2,5-Dichlorophenyl)sulfonyl]piperazine hydrochloride)
• 100248-84-8(Piperazine, 1-[(4-chlorophenyl)sulfonyl]-4-ethyl-)
• 233261-85-3(1-(3-chlorophenyl)sulfonylpiperazine)
• 946387-07-1(RN 1734)
• 524711-29-3(1-(2,5-Dichlorophenyl)sulfonylpiperazine)