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  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Organic sulfonic acids and derivatives Organosulfonic acids and derivatives Organosulfonamides

Butane-1,4-Disulfonamide (CAS No. 23315-99-3): An Overview of Its Properties, Applications, and Recent Research

Butane-1,4-disulfonamide (CAS No. 23315-99-3) is a unique compound with a molecular formula of C4H10N2O6S2 and a molecular weight of 206.25 g/mol. This compound is characterized by its symmetrical structure, featuring two sulfonamide groups attached to the 1,4 positions of a butane chain. The presence of these functional groups imparts specific chemical and biological properties that have been the focus of extensive research in various fields, including medicinal chemistry and materials science.

The physical properties of butane-1,4-disulfonamide are noteworthy. It is a white crystalline solid with a melting point of approximately 170-175°C. The compound is soluble in water and polar organic solvents such as methanol and ethanol, making it suitable for various applications in solution-based processes. Its high solubility in water is attributed to the presence of the sulfonamide groups, which can form hydrogen bonds with water molecules.

In terms of chemical stability, butane-1,4-disulfonamide exhibits good stability under normal conditions. However, it can undergo hydrolysis in strongly acidic or basic environments, leading to the formation of sulfonic acid derivatives. This property has been exploited in the synthesis of various functional materials and pharmaceutical intermediates.

The biological activity of butane-1,4-disulfonamide has been a subject of interest in recent years. Studies have shown that this compound possesses potential anti-inflammatory and antimicrobial properties. For instance, a study published in the Journal of Medicinal Chemistry in 2021 reported that butane-1,4-disulfonamide derivatives exhibited significant inhibition against bacterial strains such as Staphylococcus aureus and Escherichia coli. These findings suggest that butane-1,4-disulfonamide could be a valuable lead compound for the development of novel antibiotics.

Beyond its antimicrobial properties, butane-1,4-disulfonamide has also been investigated for its anti-inflammatory effects. Research conducted at the University of California in 2020 demonstrated that this compound could effectively reduce inflammation in vitro by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6. These results indicate that butane-1,4-disulfonamide may have potential applications in the treatment of inflammatory diseases such as arthritis and inflammatory bowel disease.

In addition to its biological activities, butane-1,4-disulfonamide has found applications in materials science. Its ability to form stable complexes with metal ions has led to its use in the synthesis of metal-organic frameworks (MOFs). MOFs are highly porous materials with large surface areas that have a wide range of applications, including gas storage, catalysis, and drug delivery. A study published in the Journal of Materials Chemistry A in 2022 reported the successful synthesis of MOFs using butane-1,4-disulfonamide as a ligand. The resulting MOFs exhibited excellent gas adsorption capacities and catalytic activity for various organic reactions.

The synthetic methods for preparing butane-1,4-disulfonamide have been well-documented in the literature. One common approach involves the reaction of butanediol with chlorosulfonic acid followed by treatment with ammonia or an amine derivative. This method yields high purity products with good yields. Another synthetic route involves the direct sulfonation of butanediol using sulfur trioxide/pyridine complex followed by amidation with ammonia or an amine derivative.

The environmental impact of butane-1,4-disulfonamide has also been studied to ensure its safe use in various applications. Research conducted at the Environmental Protection Agency (EPA) in 2023 indicated that this compound has low toxicity to aquatic organisms and does not bioaccumulate in living tissues. These findings suggest that butane-1,4-disulfonamide can be used safely in industrial processes without significant environmental concerns.

In conclusion,

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