• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds 1,3-dicarbonyl compounds
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds 1,3-dicarbonyl compounds

Comprehensive Guide to Methyl 3-Chloro-2-methyl-3-oxopropanoate (CAS No. 23185-24-2): Properties, Applications, and Industry Insights

Methyl 3-chloro-2-methyl-3-oxopropanoate (CAS No. 23185-24-2) is a versatile organic ester widely utilized in pharmaceutical intermediates, agrochemical synthesis, and specialty chemical manufacturing. This compound, characterized by its chloro and ester functional groups, has garnered significant attention due to its role in facilitating carbon-carbon bond formation and chiral synthesis. Its molecular formula, C₅H₇ClO₃, reflects a balance of reactivity and stability, making it valuable for fine chemical applications.

In recent years, the demand for methyl 3-chloro-2-methyl-3-oxopropanoate has surged alongside advancements in green chemistry and sustainable synthesis. Researchers and manufacturers are increasingly exploring its potential in biocatalysis and flow chemistry, aligning with global trends toward eco-friendly production. A common query in scientific forums is: "How can this compound optimize multistep synthesis while minimizing waste?" Studies suggest its compatibility with enzymatic reactions and microwave-assisted synthesis offers promising solutions.

The compound’s physicochemical properties include a boiling point of ~210°C and moderate solubility in polar solvents like ethanol and acetone. These traits make it suitable for high-temperature reactions and solvent-based formulations. Notably, its α-chloroketone moiety enables diverse transformations, such as nucleophilic substitutions and cyclization reactions, which are critical in producing heterocyclic compounds for drug discovery.

From an industrial perspective, CAS 23185-24-2 is often discussed in contexts like scale-up challenges and cost-effective purification. Innovations in continuous manufacturing and crystallization techniques have addressed these concerns, as highlighted in patents focusing on yield optimization. Furthermore, its role in synthesizing flavor and fragrance ingredients underscores its cross-industry relevance.

Safety and handling of methyl 3-chloro-2-methyl-3-oxopropanoate adhere to standard laboratory protocols, with emphasis on ventilation and personal protective equipment (PPE). While not classified as hazardous under normal conditions, its reactivity profile warrants precautions during storage (cool, dry environments) and transport. Regulatory compliance, such as REACH and FDA guidelines, ensures its safe use in GMP-certified facilities.

Emerging applications include its integration into photoredox catalysis and metal-organic frameworks (MOFs), areas gaining traction in materials science. As synthetic methodologies evolve, CAS 23185-24-2 continues to inspire research into atom-efficient pathways and catalytic asymmetric synthesis, answering the growing demand for high-purity intermediates.

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