• 1. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751
• 2. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
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• 3. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
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• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
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• 5. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

Professional Introduction to 3,5-Dibromo-4-Hydroxybenzyl Alcohol (CAS No. 2316-62-3)

3,5-Dibromo-4-hydroxybenzyl alcohol, with the chemical formula C?H?Br?O? and CAS number 2316-62-3, is a significant compound in the field of organic chemistry and pharmaceutical research. This compound, characterized by its dibromo and hydroxy functional groups, has garnered considerable attention due to its versatile applications in synthetic chemistry and potential roles in drug development. The unique structural features of 3,5-dibromo-4-hydroxybenzyl alcohol make it a valuable intermediate in the synthesis of various bioactive molecules.

The structure of 3,5-dibromo-4-hydroxybenzyl alcohol consists of a benzene ring substituted with two bromine atoms at the 3rd and 5th positions and a hydroxyl group at the 4th position. This arrangement imparts distinct chemical properties that are exploited in multiple synthetic pathways. The presence of bromine atoms enhances the electrophilicity of the benzene ring, making it more susceptible to nucleophilic substitution reactions. Simultaneously, the hydroxyl group introduces reactivity that is conducive to etherification, esterification, and other transformations essential in medicinal chemistry.

In recent years, 3,5-dibromo-4-hydroxybenzyl alcohol has been extensively studied for its role in the synthesis of pharmaceutical intermediates. Its structural motifs are frequently incorporated into more complex molecules designed to interact with biological targets. For instance, researchers have utilized this compound to develop novel antimicrobial agents, leveraging its ability to form stable complexes with bacterial enzymes. The dibromo substituents facilitate cross-coupling reactions, such as Suzuki-Miyaura coupling, which are pivotal in constructing biaryl structures found in many drugs.

Moreover, the hydroxybenzyl alcohol moiety is a common pharmacophore in medicinal chemistry due to its ability to form hydrogen bonds with biological targets. This property is particularly useful in designing central nervous system (CNS) drugs, where precise molecular interactions are critical for efficacy. Recent studies have highlighted the potential of derivatives of 3,5-dibromo-4-hydroxybenzyl alcohol in developing neuroprotective agents and antidepressants. The compound’s ability to modulate enzyme activity and receptor binding makes it a promising candidate for further exploration.

The synthesis of 3,5-dibromo-4-hydroxybenzyl alcohol typically involves bromination and hydroxylation reactions on a halogenated benzene precursor. Advanced synthetic methodologies have been developed to improve yield and purity, ensuring that the final product meets pharmaceutical-grade standards. Techniques such as catalytic hydrogenation and metal-catalyzed cross-coupling reactions have been optimized for large-scale production. These advancements underscore the importance of this compound in industrial applications.

Recent research has also explored the role of 3,5-dibromo-4-hydroxybenzyl alcohol in material science, particularly in the development of organic electronic materials. Its rigid aromatic core and functional groups make it a suitable candidate for designing organic semiconductors and light-emitting diodes (OLEDs). The bromine atoms provide anchoring points for further functionalization, allowing chemists to tailor the material properties for specific applications.

In conclusion, 3,5-dibromo-4-hydroxybenzyl alcohol (CAS No. 2316-62-3) is a multifaceted compound with significant implications in pharmaceuticals and materials science. Its unique structural features enable diverse synthetic applications, making it an indispensable intermediate in drug development. As research continues to uncover new possibilities for this compound, its importance is likely to grow further. The intersection of organic chemistry and medicinal chemistry continues to drive innovation, with compounds like 3,5-dibromo-4-hydroxybenzyl alcohol at the forefront.

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