Cas no 23111-45-7 (4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine)

4-(2,4-Dimethoxyphenyl)-1,3-thiazol-2-amine is a specialized thiazole derivative featuring a 2,4-dimethoxyphenyl substituent at the 4-position and an amine group at the 2-position. This compound is of interest in medicinal and synthetic chemistry due to its structural motif, which is commonly found in biologically active molecules. The presence of methoxy groups enhances its solubility and potential for further functionalization, while the thiazole core contributes to its stability and versatility in heterocyclic synthesis. It serves as a valuable intermediate for the development of pharmaceuticals, particularly in the design of kinase inhibitors and antimicrobial agents. Its well-defined structure and purity make it suitable for research applications requiring precise molecular modifications.
4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine structure
23111-45-7 structure
Product Name:4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine
CAS No:23111-45-7
MF:C11H12N2O2S
MW:236.290181159973
CID:269946
PubChem ID:745277
Update Time:2025-05-21

4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine Chemical and Physical Properties

Names and Identifiers

    • 2-Thiazolamine,4-(2,4-dimethoxyphenyl)-
    • 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine
    • 4-(2,4-Dimethoxy-phenyl)-thiazol-2-ylamine
    • 2-Amino-4-(2,4-dimethoxyphenyl)thiazol
    • 2-Amino-4-(2',4'-dimethoxyphenyl)thiazol
    • 4-(2,4-dimethoxyphenyl)-1,3-thiazole-2-ylamine
    • 4-(2,4-dimethoxyphenyl)-2-aminothiazole
    • 4-(2,4-dimethoxyphenyl)thiazol-2-amine
    • 4-(2,4-Dimethoxyphenyl)thiazol-2-yl amine
    • AC1LF1DP
    • AC1Q4CCQ
    • Oprea1_540794
    • Oprea1_871039
    • STOCK2S-71592
    • 2-amino-4-(2,4-dimethoxyphenyl) thiazole
    • 23111-45-7
    • 4-(2,4-dimethoxyphenyl)thiazol-2-ylamine
    • 2-Thiazolamine, 4-(2,4-dimethoxyphenyl)-
    • NRGCDEWBJMQJBX-UHFFFAOYSA-N
    • EU-0010654
    • DTXSID20353565
    • YAA11145
    • 4-(2, 4-dimethoxyphenyl)-1, 3-thiazol-2-amine
    • Z48847709
    • 4-(2,4-dimethoxyphenyl)-thiazol-2-ylamine
    • SCHEMBL1821573
    • EN300-00996
    • F2146-0034
    • AKOS000112490
    • MDL: MFCD02049275
    • Inchi: 1S/C11H12N2O2S/c1-14-7-3-4-8(10(5-7)15-2)9-6-16-11(12)13-9/h3-6H,1-2H3,(H2,12,13)
    • InChI Key: NRGCDEWBJMQJBX-UHFFFAOYSA-N
    • SMILES: S1C(N)=NC(=C1)C1C=CC(=CC=1OC)OC

Computed Properties

  • Exact Mass: 236.06200
  • Monoisotopic Mass: 236.06194880g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 3
  • Complexity: 230
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.2
  • Topological Polar Surface Area: 85.6?2

Experimental Properties

  • PSA: 85.61000
  • LogP: 2.99070

4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine Security Information

4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine Customs Data

  • HS CODE:2934100090
  • Customs Data:

    China Customs Code:

    2934100090

    Overview:

    2934100090. Compounds that structurally contain a non fused thiazole ring(Whether hydrogenated or not). VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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Additional information on 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine

4-(2,4-Dimethoxyphenyl)-1,3-thiazol-2-amine: A Comprehensive Overview

The compound with CAS No. 23111-45-7, commonly referred to as 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine, is a fascinating molecule with significant potential in various fields of chemistry and pharmacology. This compound belongs to the class of thiazoles, which are heterocyclic aromatic compounds with a sulfur atom and a nitrogen atom in their structure. Thiazoles are widely studied due to their unique chemical properties and diverse applications in drug discovery and material science.

4-(2,4-Dimethoxyphenyl)-1,3-thiazol-2-amine is characterized by its thiazole ring fused with a substituted phenyl group. The presence of methoxy groups at the 2 and 4 positions of the phenyl ring introduces electron-donating effects, which can influence the electronic properties of the molecule. This makes it an interesting candidate for exploring interactions in biological systems or as a building block in organic synthesis.

Recent studies have highlighted the importance of thiazole derivatives in medicinal chemistry. For instance, researchers have explored the potential of 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine as a lead compound for developing new therapeutic agents. Its structure allows for various substitution patterns, enabling the creation of analogs with tailored pharmacokinetic and pharmacodynamic properties. These analogs have shown promise in targeting specific biological pathways associated with diseases such as cancer and neurodegenerative disorders.

In addition to its medicinal applications, 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine has also been investigated for its role in material science. The molecule's aromaticity and heteroatom content make it a potential candidate for use in organic electronics or as a precursor for advanced materials like conductive polymers. Recent advancements in this area have demonstrated how such compounds can contribute to the development of more efficient electronic devices.

The synthesis of 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine involves a multi-step process that typically begins with the preparation of the thiazole ring. This is often achieved through condensation reactions involving thiourea or other sulfur-containing precursors. The substitution pattern on the phenyl ring can be controlled during synthesis to tailor the molecule's properties for specific applications.

From an analytical standpoint, 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine has been extensively studied using techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. These studies have provided valuable insights into its molecular structure and stability under various conditions. Such information is crucial for understanding how the compound behaves in different environments and how it can be optimized for practical use.

Looking ahead, the future of 4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-amine lies in its ability to serve as a versatile platform for innovation across multiple disciplines. Its unique combination of structural features and functional groups positions it as a valuable tool in both academic research and industrial applications. As researchers continue to explore its potential, this compound is likely to play an increasingly important role in advancing our understanding of complex chemical systems.

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