• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

Comprehensive Guide to 4-(Difluoromethoxy)-1H-Pyrazole (CAS No. 2306173-79-3): Properties, Applications, and Market Insights

4-(Difluoromethoxy)-1H-pyrazole (CAS No. 2306173-79-3) is a fluorinated heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. With the increasing demand for fluorinated pyrazole derivatives, this compound stands out due to its unique structural features and versatile applications. The presence of the difluoromethoxy group enhances its metabolic stability and bioavailability, making it a valuable intermediate in drug discovery.

The chemical structure of 4-(difluoromethoxy)-1H-pyrazole consists of a pyrazole ring substituted at the 4-position with a difluoromethoxy moiety. This modification significantly influences its physicochemical properties, such as lipophilicity and electronic effects, which are critical for its performance in various applications. Researchers are particularly interested in its potential as a bioisostere for other functional groups, enabling the design of novel therapeutic agents.

One of the most prominent applications of 4-(difluoromethoxy)-1H-pyrazole is in the development of small-molecule inhibitors. Its incorporation into drug candidates has shown promise in targeting enzymes and receptors involved in inflammatory and metabolic diseases. Recent studies highlight its role in the synthesis of kinase inhibitors, which are pivotal in oncology research. The compound’s ability to modulate protein-protein interactions further expands its utility in medicinal chemistry.

In the agrochemical sector, 4-(difluoromethoxy)-1H-pyrazole derivatives are being explored for their herbicidal and fungicidal properties. The difluoromethoxy group contributes to the compound’s stability under environmental conditions, ensuring prolonged efficacy. This has led to its inclusion in next-generation crop protection formulations, addressing the growing need for sustainable agricultural solutions.

The synthesis of 4-(difluoromethoxy)-1H-pyrazole typically involves multi-step organic reactions, including fluorination and cyclization processes. Advances in green chemistry have enabled more efficient and environmentally friendly production methods, reducing the reliance on hazardous reagents. These innovations align with the global push toward sustainable chemical manufacturing practices.

Market trends indicate a rising demand for fluorinated pyrazole compounds, driven by their expanding applications in pharmaceuticals and agriculture. The compound’s CAS No. 2306173-79-3 is frequently searched in scientific databases, reflecting its relevance in ongoing research. Analysts project steady growth in its market value, particularly in regions with robust pharmaceutical and agrochemical industries.

From a regulatory perspective, 4-(difluoromethoxy)-1H-pyrazole is subject to standard safety and environmental guidelines. Proper handling and storage are essential to ensure its stability and prevent degradation. Researchers and manufacturers must adhere to Good Laboratory Practices (GLP) and Good Manufacturing Practices (GMP) to maintain quality and compliance.

Future research on 4-(difluoromethoxy)-1H-pyrazole is expected to focus on optimizing its synthetic routes and exploring new applications. The compound’s potential in personalized medicine and precision agriculture is particularly exciting, as these fields prioritize tailored solutions for complex challenges. Collaborations between academia and industry will likely accelerate its adoption in innovative products.

In summary, 4-(difluoromethoxy)-1H-pyrazole (CAS No. 2306173-79-3) is a versatile and high-value compound with broad applications in pharmaceuticals and agrochemicals. Its unique properties, coupled with advancements in synthetic chemistry, position it as a key player in the development of next-generation therapeutics and crop protection agents. As research continues to uncover its full potential, this compound is poised to make significant contributions to science and industry.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)