• 1. How does the combination of the nitro group and fluorine atoms affect the (co)crystallization behaviour of arylenediamines?
  Tamara A. Vaganova,Yurij V. Gatilov,Natalia A. Kryuchkova,Denis P. Pishchur,Anastasia A. Zhukovets,Evgenij V. Malykhin CrystEngComm 2023 25 3284
• 2. Synthesis of the farnesyl ether 2,3,5-trifluoro-6-hydroxy-4-[(E,E?)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]nitrobenzene, and related compounds containing a substituted hydroxytrifluorophenyl residue: novel inhibitors of protein farnesyltransferase, geranylgeranyltransferase I and squalene synthase
  Jonathan H. Marriott,Amelia M. Moreno Barber,Ian R. Hardcastle,Martin G. Rowlands,Rachel M. Grimshaw,Stephen Neidle,Michael Jarman J. Chem. Soc. Perkin Trans. 1 2000 4265

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

Professional Introduction to 3,5-Difluoronitrobenzene (CAS No. 2265-94-3)

3,5-Difluoronitrobenzene, identified by the chemical compound code CAS No. 2265-94-3, is a fluorinated nitroaromatic compound that has garnered significant attention in the field of organic chemistry and pharmaceutical research. This compound, characterized by its dual fluorine substituents and nitro group, exhibits unique chemical properties that make it a valuable intermediate in the synthesis of various agrochemicals, pharmaceuticals, and specialty chemicals. The structural features of 3,5-difluoronitrobenzene contribute to its reactivity and versatility, enabling its application in multiple synthetic pathways.

The significance of 3,5-difluoronitrobenzene in modern chemical synthesis cannot be overstated. Its molecular structure, which includes both fluorine atoms and a nitro group, allows for a wide range of chemical transformations. These transformations are crucial for the development of novel compounds with enhanced biological activity. Recent studies have highlighted the compound's role in the synthesis of bioactive molecules, particularly in the development of new therapeutic agents.

In the realm of pharmaceutical research, 3,5-difluoronitrobenzene has been explored as a key intermediate in the production of various pharmacologically active compounds. The presence of fluorine atoms in its structure imparts specific electronic and steric properties that can influence the efficacy and selectivity of drug candidates. For instance, fluorinated aromatic compounds are known to exhibit improved metabolic stability and bioavailability, making them attractive for medicinal chemistry applications.

One of the most compelling aspects of 3,5-difluoronitrobenzene is its utility in cross-coupling reactions, which are fundamental to modern synthetic organic chemistry. These reactions allow for the formation of carbon-carbon bonds and are essential for constructing complex molecular frameworks. The nitro group in 3,5-difluoronitrobenzene can be selectively reduced to an amine or converted into other functional groups, providing multiple avenues for synthetic manipulation.

The latest research findings indicate that 3,5-difluoronitrobenzene is being utilized in the development of novel agrochemicals. Fluorinated nitroaromatics are known to possess potent biological activity against various pests and pathogens. The structural modifications introduced by fluorine atoms enhance the binding affinity of these compounds to biological targets, leading to more effective pest control solutions.

• 2369-12-2(5-Fluoro-3-nitroaniline)
• 364-74-9(2,5-Difluoronitrobenzene)
• 364-78-3(4-fluoro-2-nitro-aniline)
• 350-46-9(1-Fluoro-4-nitrobenzene)
• 315-14-0(1,3,5-trifluoro-2-nitrobenzene)
• 369-35-7(2-Fluoro-4-nitroaniline)
• 2369-11-1(5-Fluoro-2-nitroaniline)
• 446-35-5(2,4-Difluoronitrobenzene)
• 369-34-6(3,4-Difluoronitrobenzene)
• 402-67-5(1-fluoro-3-nitro-benzene)