• 1. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 2. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 5. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Primary alcohols
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Primary alcohols

Comprehensive Overview of Ethyl-1,2,2,2-d4 Alcohol (CAS No. 22544-43-0): Properties, Applications, and Innovations

Ethyl-1,2,2,2-d4 Alcohol, identified by its CAS registry number 22544-43-0, is a deuterated variant of ethanol, where four hydrogen atoms are replaced with deuterium isotopes. This isotopic labeling significantly enhances its utility in advanced scientific research, particularly in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The compound’s unique molecular structure makes it indispensable for tracing metabolic pathways, studying reaction mechanisms, and developing deuterated pharmaceuticals.

The growing demand for isotopically labeled compounds in life sciences and material research has positioned Ethyl-1,2,2,2-d4 Alcohol as a critical reagent. Researchers frequently inquire about its synthetic routes, purity standards, and storage conditions, reflecting its niche yet expanding role. Unlike conventional ethanol, this deuterated form minimizes spectral interference in analytical techniques, addressing common challenges in proteomics and metabolomics.

Recent advancements in green chemistry have spurred interest in sustainable production methods for deuterated compounds. Ethyl-1,2,2,2-d4 Alcohol is no exception, with studies exploring catalytic deuteration and biocatalytic approaches to reduce costs and environmental impact. These innovations align with the broader trend of eco-friendly chemical synthesis, a topic gaining traction in academic and industrial forums.

From an industrial perspective, CAS No. 22544-43-0 is pivotal in OLED technology and organic electronics, where deuterated materials improve device stability and performance. Searches for "deuterated solvents for OLEDs" or "isotope effects in organic semiconductors" highlight this intersection. Additionally, its role in neutron scattering experiments—a technique vital for quantum material studies—further underscores its multidisciplinary relevance.

Quality control remains a priority for users of Ethyl-1,2,2,2-d4 Alcohol. FAQs often revolve around "how to verify deuterium enrichment levels" or "compatibility with HPLC systems." Reputable suppliers provide certificates of analysis (CoA) detailing isotopic purity (>98% D-atom incorporation) and residual solvent profiles, ensuring reproducibility in sensitive applications like drug discovery.

Emerging discussions also link deuterated compounds to longevity research, as studies explore isotope effects on cellular aging. While speculative, such connections amplify public curiosity, driving searches like "deuterium and anti-aging." However, rigorous scientific validation is ongoing, and CAS 22544-43-0 serves primarily as a tool for mechanistic insights rather than direct therapeutic use.

In summary, Ethyl-1,2,2,2-d4 Alcohol exemplifies the synergy between fundamental chemistry and cutting-edge technology. Its versatility across NMR, MS, materials science, and biomedical research ensures sustained interest, while eco-conscious synthesis methods address contemporary sustainability goals. For researchers navigating isotopic labeling challenges, this compound offers precision and reliability, cementing its status as a cornerstone in modern laboratories.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)